Mifepristone
Ectopic Pregnancy, Brain Neoplasms ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Progestin Antagonist
Controlled Drug Substance
NO
Mifepristone
Learn more about this medicine -
Click HereSummary
Mifepristone is primarily used for medical abortion in pregnancies up to 10 weeks and for treating Cushing's syndrome, a condition characterized by high blood sugar levels due to excess cortisol.
Mifepristone works by blocking progesterone, a hormone necessary for pregnancy. This results in the detachment of the pregnancy from the uterus. In Cushing's syndrome, it helps reduce high blood sugar by blocking cortisol effects.
For medical abortion, the typical dose is 200 mg taken once, followed by misoprostol 800 mcg after 24-48 hours. For Cushing's syndrome, the dose starts at 300 mg per day and may be increased based on response. Mifepristone should be taken orally with water.
Common side effects include nausea, vomiting, cramping, diarrhea, headache, and dizziness. Serious risks include excessive bleeding, infection, and incomplete abortion.
Women with ectopic pregnancy, bleeding disorders, severe anemia, or adrenal insufficiency should avoid it. It is also not recommended for those with liver disease, kidney problems, or heart conditions. Always consult a doctor before taking Mifepristone.
Indications and Purpose
How does Mifepristone work?
Mifepristone works by blocking progesterone, a hormone needed for pregnancy. This causes the uterine lining to break down, making it unsuitable for pregnancy. In Cushing’s syndrome, it blocks cortisol receptors, helping reduce high blood sugar levels. Its action depends on the condition being treated.
How does one know if Mifepristone is working?
For abortion, signs include bleeding and cramping within 24–48 hours after taking misoprostol. A follow-up test or ultrasound after 7–14 days confirms success. In Cushing’s syndrome, improvement in blood sugar levels and symptoms indicates effectiveness. If no changes occur, consult a doctor for further evaluation.
Is Mifepristone effective?
Yes, Mifepristone is highly effective for medical abortion, with a success rate of 95-98% when combined with misoprostol. It is also effective in treating Cushing’s syndrome, helping control blood sugar and cortisol levels. However, its effectiveness depends on correct usage and medical supervision.
What is Mifepristone?
Mifepristone is a medication used primarily for medical abortion in early pregnancy and for treating Cushing’s syndrome. It works by blocking progesterone, a hormone needed to maintain pregnancy, leading to the detachment of the pregnancy from the uterus. It is often used with misoprostol to complete the abortion process. In Cushing’s syndrome, it helps reduce high blood sugar by blocking cortisol effects. It is a prescription drug and should be taken under medical supervision.
What is Mifepristone used for?
Mifepristone is primarily used for medical abortion in pregnancies up to 10 weeks. It is also used to treat Cushing’s syndrome in patients with high blood sugar levels due to excess cortisol. Additionally, it may be used in certain cases of missed miscarriage and as an investigational drug for other hormonal conditions.
Directions for Use
For how long do I take Mifepristone?
For medical abortion, it is taken as a single dose, followed by misoprostol after 24–48 hours. For Cushing’s syndrome, it is taken daily for long-term management, depending on the patient's response and doctor’s guidance. The duration varies based on the condition being treated, and medical follow-up is necessary to assess effectiveness and any side effects.
How do I take Mifepristone?
Mifepristone should be taken orally with water. For abortion, it is followed by misoprostol, which helps expel the pregnancy. It is best taken under medical supervision to monitor any complications. Do not take it with grapefruit juice, as it may interfere with absorption. Always follow your doctor’s instructions for the best results and safety.
How long does it take for Mifepristone to start working?
For abortion, Mifepristone starts working within 24 to 48 hours, causing the pregnancy to detach from the uterus. Misoprostol, taken afterward, induces uterine contractions to expel the pregnancy. For Cushing’s syndrome, the effects may take several weeks to regulate blood sugar and cortisol levels.
How should I store Mifepristone?
Store at room temperature (20–25°C) in a dry place, away from light and moisture. Keep it out of reach of children. Do not use expired medication, as it may lose effectiveness.
What is the usual dose of Mifepristone?
For medical abortion, the typical dose is 200 mg taken once, followed by misoprostol (800 mcg) after 24–48 hours. For Cushing’s syndrome, the dose starts at 300 mg per day and may be increased based on response. The dosage may vary depending on the individual’s health condition and should be prescribed by a doctor to ensure safety and effectiveness.
Warnings and Precautions
Can I take Mifepristone with other prescription drugs?
Mifepristone interacts with anticoagulants, corticosteroids, antifungal drugs, and certain antibiotics, affecting its function. If you take other medications, consult a doctor to avoid harmful interactions. It is essential to disclose all medicines before starting treatment.
Can I take Mifepristone with vitamins or supplements?
Some vitamins and supplements, like St. John’s Wort, may reduce its effectiveness. Avoid grapefruit juice and high-dose vitamin C, as they can interfere with absorption. Always check with your doctor before taking supplements with Mifepristone.
Can Mifepristone be taken safely while breastfeeding?
Mifepristone may pass into breast milk, but its effects on infants are unclear. It is advised to pump and discard breast milk for a few days after taking it. Consult a doctor before using it while breastfeeding.
Can Mifepristone be taken safely while pregnant?
No, Mifepristone is used to terminate pregnancy and should not be taken by women wanting to continue pregnancy. If mistakenly taken, seek immediate medical help to assess the situation and possible complications.
Is it safe to drink alcohol while taking Mifepristone?
Alcohol may increase dizziness, nausea, and liver strain. It is best to avoid alcohol while taking Mifepristone.
Is it safe to exercise while taking Mifepristone?
Light activity is fine, but avoid heavy exercise if you feel weak, dizzy, or have heavy bleeding. Listen to your body and rest if needed.
Is Mifepristone safe for the elderly?
Mifepristone is not commonly used in elderly patients except for Cushing’s syndrome. If prescribed, close monitoring is needed for liver function, blood sugar, and potential side effects. Always consult a doctor before use.
Who should avoid taking Mifepristone?
Women with ectopic pregnancy, bleeding disorders, severe anemia, or adrenal insufficiency should avoid it. It is also not recommended for those with liver disease, kidney problems, or heart conditions. Always consult a doctor before taking Mifepristone to ensure it is safe based on your health condition.
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