Metoclopramide
Gastroesophageal Reflux, Postoperative Nausea and Vomiting ... show more
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Dopamine-2 Receptor Antagonist
Controlled Drug Substance
No
Metoclopramide
Summary
Metoclopramide is primarily used to treat nausea, vomiting, and gastric problems such as gastroesophageal reflux disease (GERD) and delayed stomach emptying. It can also be used to manage symptoms from chemotherapy or after surgery.
Metoclopramide works by increasing the movement of the stomach and intestines, helping food pass through the digestive system more easily. It also strengthens the muscles at the bottom of your esophagus to prevent stomach acid from flowing back.
Typically, adults take 5 to 10 mg of Metoclopramide 3 to 4 times per day, usually before meals and at bedtime. For children, the dose is determined based on their weight and specific condition. It is usually taken orally in tablet form or as a liquid.
Common side effects of Metoclopramide include drowsiness, fatigue, and diarrhea. Some people may also experience headaches, stomach upset, and mood changes. Serious side effects could include uncontrollable muscle movements, especially with long-term use.
Metoclopramide can cause serious side effects like Neuroleptic Malignant Syndrome, a life-threatening condition with symptoms like high fever and stiff muscles. It's important to avoid alcohol, driving, or operating machinery while taking this medication. Long-term use is not recommended, and it should not be used by individuals with certain medical conditions or taking certain other medications.
Indications and Purpose
How does Metoclopramide work?
Metoclopramide works by increasing muscle contractions in the upper digestive tract, which helps speed up stomach emptying. It blocks dopamine receptors in the brain, reducing nausea and vomiting. Think of it like a traffic controller, helping food move smoothly through your digestive system. This action helps relieve symptoms of nausea, vomiting, and gastroparesis, which is delayed stomach emptying. Metoclopramide is effective for these conditions, providing relief and improving digestion.
Is Metoclopramide effective?
Yes, Metoclopramide is effective for treating nausea, vomiting, and gastroparesis, which is delayed stomach emptying. It works by increasing muscle contractions in the upper digestive tract, speeding up stomach emptying. Clinical studies support its effectiveness in relieving these symptoms. If you have concerns about how well Metoclopramide is working for you, talk with your doctor. They can assess your treatment and make any necessary adjustments to ensure the best outcomes.
What is Metoclopramide?
Metoclopramide is a medication used to treat nausea, vomiting, and gastroparesis, which is delayed stomach emptying. It belongs to a class of drugs called prokinetics, which help increase muscle contractions in the upper digestive tract. This action speeds up stomach emptying and helps relieve symptoms. Metoclopramide is also used to prevent nausea and vomiting caused by chemotherapy or surgery. It can be used alone or with other therapies, depending on your condition.
Directions for Use
For how long do I take Metoclopramide?
Metoclopramide is usually used for short-term treatment of acute symptoms like nausea and vomiting. The duration of use depends on your specific condition and your doctor's recommendations. It's important to follow your doctor's instructions and not use Metoclopramide for longer than prescribed. If you have questions about how long to take this medication, consult your healthcare provider. They can provide guidance based on your health needs.
How do I dispose of Metoclopramide?
Dispose of Metoclopramide by taking it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If a take-back program isn't available, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. Always keep medications out of reach of children.
How do I take Metoclopramide?
Take Metoclopramide as directed by your doctor. It's usually taken 30 minutes before meals and at bedtime. The frequency is typically three to four times a day. You can take it with or without food. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose. Do not double up on doses. Avoid alcohol while taking Metoclopramide, as it can increase drowsiness. Always follow your doctor's specific instructions for the best results.
How long does it take for Metoclopramide to start working?
Metoclopramide starts working within 30 to 60 minutes after taking it. The full therapeutic effect may take a few days, depending on your condition. Factors like your overall health and the severity of your symptoms can affect how quickly you notice improvements. Always take Metoclopramide as prescribed for the best results. If you have concerns about how quickly it's working, talk with your doctor. They can provide guidance based on your specific situation.
How should I store Metoclopramide?
Store Metoclopramide at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in the bathroom, where humidity can affect the medication. Always keep it out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication. If you have questions about storage, consult your pharmacist or doctor.
What is the usual dose of Metoclopramide?
The usual starting dose of Metoclopramide for adults is 10 mg, taken 30 minutes before meals and at bedtime, up to four times a day. The maximum recommended dose is 60 mg per day. For children and the elderly, dose adjustments may be necessary, and your doctor will provide specific instructions. Always follow your doctor's dosing recommendations for your personal health needs. If you have any questions about your dose, consult your healthcare provider.
Warnings and Precautions
Can I take Metoclopramide with other prescription drugs?
Metoclopramide can interact with other medications, increasing the risk of side effects. For example, it can enhance the sedative effects of alcohol and other central nervous system depressants, which are substances that slow down brain activity. It can also interact with medications like antipsychotics, increasing the risk of movement disorders. Always inform your doctor about all medications you are taking to avoid potential interactions. They can help manage your treatment safely.
Can Metoclopramide be taken safely while breastfeeding?
Metoclopramide is generally considered safe while breastfeeding, but it can pass into breast milk in small amounts. There is limited evidence on its effects on breastfed infants, so consult your doctor before using it. They can help determine if it's the right choice for you and your baby. Your doctor will consider your specific health needs and the potential effects on your milk supply and infant before recommending this medication.
Can Metoclopramide be taken safely while pregnant?
Metoclopramide is generally considered safe during pregnancy, but it's important to use it only if the benefits outweigh the risks. Limited evidence is available, so always consult your doctor before taking Metoclopramide while pregnant. They can help determine if it's the right choice for you. Your doctor will consider your specific health needs and the potential effects on your pregnancy before recommending this medication.
Does Metoclopramide have adverse effects?
Yes, Metoclopramide can have adverse effects, which are unwanted reactions to a medication. Common adverse effects include drowsiness, fatigue, and restlessness. Serious side effects, like tardive dyskinesia, which involves involuntary muscle movements, are rare but require immediate medical attention. If you notice any new or worsening symptoms, contact your doctor. They can help determine if Metoclopramide is the cause and suggest appropriate action. Always report adverse effects to your healthcare provider.
Does Metoclopramide have any safety warnings?
Yes, Metoclopramide has important safety warnings. It can cause a serious condition called tardive dyskinesia, which involves involuntary muscle movements. This risk increases with long-term use. Metoclopramide can also cause drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. Not following these warnings can lead to serious health issues. Always adhere to your doctor's instructions and report any unusual symptoms immediately.
Is it safe to drink alcohol while taking Metoclopramide?
It's best to avoid alcohol while taking Metoclopramide. Alcohol can increase the risk of side effects like drowsiness and dizziness. These symptoms can impair your ability to perform tasks that require alertness, such as driving. If you choose to drink, limit your alcohol intake and be aware of how it affects you. Always talk with your doctor about alcohol use while taking Metoclopramide to get personalized advice based on your health situation.
Is it safe to exercise while taking Metoclopramide?
Yes, you can exercise while taking Metoclopramide, but be cautious. This medication can cause drowsiness or dizziness, which might affect your exercise capacity. If you feel dizzy or lightheaded, stop exercising and rest. Drink plenty of water to stay hydrated. Avoid strenuous activities until you know how Metoclopramide affects you. If you have concerns about exercising while on this medication, talk with your doctor for personalized advice.
Is it safe to stop Metoclopramide?
Metoclopramide is usually used for short-term treatment of acute conditions. Stopping it suddenly is generally safe, but always consult your doctor before making any changes. They can provide guidance on how to stop the medication safely, if needed. If you stop Metoclopramide without medical advice, your symptoms may return or worsen. Your doctor can help you manage your condition effectively and safely.
Is Metoclopramide addictive?
Metoclopramide is not considered addictive or habit-forming. It does not cause physical or psychological dependence. However, it should be used as prescribed by your doctor. If you have concerns about medication dependence, discuss them with your healthcare provider. They can provide reassurance and guidance on the safe use of Metoclopramide. Always follow your doctor's instructions to avoid any potential issues.
Is Metoclopramide safe for the elderly?
Metoclopramide can be used by the elderly, but they are more vulnerable to its side effects, like drowsiness and tardive dyskinesia, which involves involuntary muscle movements. These risks are higher in older adults. It's important for elderly patients to be closely monitored by their doctor while taking Metoclopramide. The doctor may adjust the dose to minimize risks. Always follow your doctor's instructions and report any unusual symptoms immediately.
What are the most common side effects of Metoclopramide?
Common side effects of Metoclopramide include drowsiness, fatigue, and restlessness. These are unwanted reactions that can occur when taking the medication. Most people tolerate Metoclopramide well, but if you experience new symptoms, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication. They can help determine if the side effects are related to Metoclopramide and suggest ways to manage them.
Who should avoid taking Metoclopramide?
Metoclopramide should not be used if you have a history of tardive dyskinesia, which involves involuntary muscle movements, or if you have a bowel obstruction. These are absolute contraindications due to severe risks. Use caution if you have kidney problems or Parkinson's disease, as these are relative contraindications. Always consult your doctor before starting Metoclopramide to ensure it's safe for you. They can help weigh the benefits and risks based on your health condition.
Forms / Brands
