Methylergonovine
Postpartum Hemorrhage
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Ergot Derivative
Controlled Drug Substance
No
Methylergonovine
Summary
Methylergonovine is used to prevent or control bleeding from the uterus after childbirth or an abortion. It is also used to manage uterine atony and subinvolution of the uterus following delivery of the placenta.
Methylergonovine acts directly on the smooth muscle of the uterus. It increases the tone, rate, and amplitude of contractions. This helps control bleeding and aids in the return of the uterus to its normal size and shape after childbirth.
Methylergonovine is typically taken orally as a tablet. The usual dosage is one 0.2 mg tablet three or four times a day, for a maximum of one week.
Common side effects of Methylergonovine include hypertension, headache, nausea, vomiting, and abdominal pain. Serious adverse effects can include seizures, chest pain, fast heartbeat, difficulty breathing, and dizziness.
Methylergonovine should not be used during pregnancy due to the risk of causing harm to the fetus. It is also contraindicated in patients with hypertension, toxemia, and hypersensitivity. Caution is advised in patients with impaired hepatic or renal function, coronary artery disease, and during breastfeeding.
Indications and Purpose
How does Methylergonovine work?
Methylergonovine acts directly on the smooth muscle of the uterus, increasing the tone, rate, and amplitude of contractions. This helps to control bleeding by inducing a rapid and sustained uterotonic effect.
Is Methylergonovine effective?
Methylergonovine is effective in preventing and controlling postpartum hemorrhage by acting directly on the smooth muscle of the uterus, increasing the tone, rate, and amplitude of contractions. This helps reduce blood loss after childbirth.
What is Methylergonovine?
Methylergonovine is used to prevent or treat bleeding from the uterus after childbirth or an abortion. It works by acting on the smooth muscle of the uterus, increasing contractions to reduce blood loss. It is part of the ergot alkaloid class of drugs.
Directions for Use
For how long do I take Methylergonovine?
Methylergonovine is typically used for a maximum of one week. It is important to follow your doctor's instructions regarding the duration of use.
How do I take Methylergonovine?
Methylergonovine should be taken exactly as prescribed by your doctor, typically three or four times a day. There are no specific food restrictions mentioned, but it is important to follow your doctor's instructions regarding its use.
How long does it take for Methylergonovine to start working?
Methylergonovine starts working within 5-10 minutes after oral administration, 2-5 minutes after intramuscular administration, and immediately after intravenous administration.
How should I store Methylergonovine?
Store Methylergonovine in its original container, tightly closed, at room temperature, away from light, excess heat, and moisture. Keep it out of reach of children and do not store it in the bathroom.
What is the usual dose of Methylergonovine?
For adults, Methylergonovine is typically taken as one tablet (0.2 mg) three or four times a day for a maximum of one week. The safety and effectiveness in children have not been established, so it is not typically prescribed for pediatric use. Always follow your doctor's specific instructions.
Warnings and Precautions
Can I take Methylergonovine with other prescription drugs?
Methylergonovine should not be coadministered with potent CYP 3A4 inhibitors like certain antibiotics, HIV protease inhibitors, or antifungals, as these can lead to serious adverse events. Caution is also advised when used with beta-blockers, anesthetics, and other vasoconstrictors.
Can Methylergonovine be taken safely while breastfeeding?
Mothers should not breastfeed during treatment with Methylergonovine and should wait at least 12 hours after the last dose before resuming breastfeeding. Milk secreted during this period should be discarded to avoid adverse effects on the infant.
Can Methylergonovine be taken safely while pregnant?
Methylergonovine is contraindicated during pregnancy due to its uterotonic effects, which can harm the fetus. It should only be used after delivery to manage postpartum hemorrhage.
Is Methylergonovine safe for the elderly?
For elderly patients, dose selection should be cautious, usually starting at the low end of the dosing range. This is due to the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy in older adults.
Who should avoid taking Methylergonovine?
Methylergonovine should not be used in individuals with hypertension, toxemia, pregnancy, or hypersensitivity to the drug. It should be used cautiously in those with impaired liver or kidney function and should not be administered intravenously routinely due to the risk of sudden hypertensive and cerebrovascular accidents.
