Methenamine
Escherichia coli Infections, Cystitis ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Methenamine
Summary
Methenamine is used to treat and prevent urinary tract infections, particularly when long-term therapy is necessary. It is typically used after the infection has been eradicated with other antimicrobial agents.
Methenamine works by converting to formaldehyde in acidic urine, which has antibacterial properties. This helps to eliminate bacteria in the urinary tract, thus preventing and treating infections.
For adults and children over 12 years, the usual dose is 1 gram twice daily. For children aged 6 to 12 years, the dose is 0.5 to 1 gram twice daily. Always take Methenamine as directed by your doctor, usually with food or milk to prevent stomach upset.
Common side effects of Methenamine include upset stomach, vomiting, diarrhea, and stomach cramps. Serious adverse effects may include skin rash, hives, and itching. If these symptoms are severe or persistent, consult your doctor.
Methenamine should not be used in patients with renal insufficiency, severe hepatic insufficiency, or severe dehydration. It should also not be used for acute infections causing systemic symptoms. Pregnant women should use Methenamine only if the potential benefit justifies the potential risk to the fetus.
Indications and Purpose
How does Methenamine work?
Methenamine is hydrolyzed to formaldehyde in acidic urine, which has antibacterial properties. This helps eliminate bacteria in the urinary tract, preventing and treating infections.
Is Methenamine effective?
Methenamine is effective in treating and preventing urinary tract infections by converting to formaldehyde in acidic urine, which has antibacterial properties. Its effectiveness is supported by its ability to maintain antibacterial activity in the urine when taken as directed.
What is Methenamine?
Methenamine is an antibiotic used to treat and prevent urinary tract infections. It works by converting to formaldehyde in acidic urine, which kills bacteria. It is often used for long-term treatment to prevent infection recurrence.
Directions for Use
For how long do I take Methenamine?
Methenamine is typically used on a long-term basis to treat chronic urinary tract infections and to prevent recurrence. The exact duration should be determined by a healthcare provider based on individual needs.
How do I take Methenamine?
Take Methenamine exactly as directed by your doctor, usually with food or milk to prevent stomach upset. Avoid alkaline foods and medications that may increase urine pH, as they can reduce the drug's effectiveness.
How long does it take for Methenamine to start working?
Methenamine starts showing antibacterial activity in the urine within 30 minutes after a single dose. Continuous antibacterial activity is maintained when taken as prescribed.
How should I store Methenamine?
Store Methenamine in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and do not store it in the bathroom.
What is the usual dose of Methenamine?
For adults and children over 12 years, the usual dose is 1 gram twice daily. For children aged 6 to 12 years, the dose is 0.5 to 1 gram twice daily. Always follow your doctor's instructions.
Warnings and Precautions
Can I take Methenamine with other prescription drugs?
Methenamine may interact with sulfonamides, leading to crystalluria. Alkaline agents can reduce its effectiveness by increasing urine pH. Always inform your doctor about all medications you are taking to avoid interactions.
Can Methenamine be taken safely while breastfeeding?
Methenamine is excreted in human milk. Due to potential adverse reactions in nursing infants, a decision should be made to either discontinue nursing or the drug, considering its importance to the mother.
Can Methenamine be taken safely while pregnant?
Methenamine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no adequate and well-controlled studies in pregnant women, so consult your doctor for personalized advice.
Is it safe to exercise while taking Methenamine?
Methenamine does not typically limit the ability to exercise. However, if you experience any side effects that affect your ability to exercise, consult your doctor.
Is Methenamine safe for the elderly?
Elderly patients should use Methenamine with caution, especially if they have renal or hepatic insufficiency. Regular monitoring and dose adjustments may be necessary. Consult a healthcare provider for personalized advice.
Who should avoid taking Methenamine?
Methenamine is contraindicated in patients with renal insufficiency, severe hepatic insufficiency, or severe dehydration. It should not be used in acute parenchymal infections causing systemic symptoms. Patients with hepatic insufficiency should be cautious due to potential adverse effects.
