Mecamylamine
Malignant Hypertension, Tourette Syndrome
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Autonomic Ganglionic Blocker
Controlled Drug Substance
No
Mecamylamine
Summary
Mecamylamine is used to treat moderately severe to severe essential hypertension, and uncomplicated cases of malignant hypertension. It is not suitable for mild, moderate, or labile hypertension.
Mecamylamine works by blocking nerve transmission in the autonomic nervous system. This reduces blood pressure by decreasing activity in the sympathetic nervous system, leading to blood vessels widening and reduced heart output.
The usual adult dosage for Mecamylamine starts with one 2.5 mg tablet twice a day. Adjustments are made based on blood pressure response. The average total daily dosage is 25 mg, divided into three doses. It's taken orally.
Common side effects of Mecamylamine include dizziness, lightheadedness, constipation, nausea, vomiting, mental changes, and fatigue. Serious adverse effects may include mental aberrations, convulsions, and interstitial pulmonary edema.
Mecamylamine is contraindicated in patients with coronary insufficiency, recent myocardial infarction, uremia, glaucoma, and hypersensitivity to the product. Caution is advised in patients with renal insufficiency, cerebral or coronary arteriosclerosis.
Indications and Purpose
How does Mecamylamine work?
Mecamylamine works as a ganglion blocker, which means it inhibits the transmission of nerve impulses in the autonomic ganglia. This action leads to a reduction in blood pressure by decreasing the sympathetic nervous system's influence on the cardiovascular system. It is absorbed from the gastrointestinal tract and excreted slowly in the urine.
Is Mecamylamine effective?
Mecamylamine is a potent antihypertensive agent that reduces blood pressure in both normotensive and hypertensive individuals. It has a gradual onset of action and a long-lasting effect, making it effective for managing hypertension. The drug is almost completely absorbed from the gastrointestinal tract, leading to consistent blood pressure reduction in most patients with hypertensive cardiovascular disease.
What is Mecamylamine?
Mecamylamine is an oral antihypertensive agent used to manage moderately severe to severe essential hypertension and uncomplicated cases of malignant hypertension. It works by blocking ganglionic transmission, leading to a reduction in blood pressure. The drug is absorbed from the gastrointestinal tract and has a gradual onset of action with long-lasting effects.
Directions for Use
For how long do I take Mecamylamine?
The duration of use for Mecamylamine is not specified in the provided content. It is typically used for managing hypertension, and the duration would depend on the individual's response to treatment and the doctor's recommendation. Regular monitoring and consultation with a healthcare provider are essential to determine the appropriate length of treatment.
How do I take Mecamylamine?
Mecamylamine can be taken with or without food, but taking it after meals may result in more gradual absorption and smoother blood pressure control. There are no specific food restrictions mentioned, but it is important to maintain a consistent sodium intake and consult your healthcare provider for personalized dietary advice.
How long does it take for Mecamylamine to start working?
Mecamylamine has a gradual onset of action, typically taking between 1/2 to 2 hours to start reducing blood pressure. Its effects are long-lasting, usually persisting for 6 to 12 hours or more. It is important to follow your healthcare provider's instructions and monitor your blood pressure regularly.
How should I store Mecamylamine?
Mecamylamine should be stored at a controlled room temperature of 20°C to 25°C (68°F to 77°F), with excursions permitted to 15°C to 30°C (59°F to 86°F). It should be dispensed in a tight container to protect it from moisture and light. Always keep the medication out of the reach of children.
What is the usual dose of Mecamylamine?
The usual adult dosage of Mecamylamine starts with one 2.5 mg tablet twice a day. This can be adjusted by increments of 2.5 mg at intervals of not less than 2 days until the desired blood pressure response is achieved. The average total daily dosage is 25 mg, usually in three divided doses. For children, safety and effectiveness have not been established, so it is not typically recommended for pediatric use.
Warnings and Precautions
Can I take Mecamylamine with other prescription drugs?
Mecamylamine's action may be potentiated by anesthesia, other antihypertensive drugs, and alcohol. Patients receiving antibiotics and sulfonamides should generally avoid ganglion blockers like Mecamylamine. It is important to inform your healthcare provider of all medications you are taking to avoid potential interactions and adjust dosages accordingly.
Can Mecamylamine be taken safely while breastfeeding?
Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. It is important to consult a healthcare provider to make an informed decision.
Can Mecamylamine be taken safely while pregnant?
There is no strong evidence from human studies on the effects of Mecamylamine during pregnancy. Animal reproduction studies have not been conducted, and it is not known whether Mecamylamine can cause fetal harm. It should be given to a pregnant woman only if clearly needed, and the potential benefits must be weighed against the risks.
Is it safe to drink alcohol while taking Mecamylamine?
Drinking alcohol can increase the dizziness, lightheadedness, or fainting effects of Mecamylamine, especially when rising from a sitting or lying position. Therefore, it is advisable to limit alcohol consumption while taking this medication to avoid these enhanced side effects.
Is it safe to exercise while taking Mecamylamine?
Mecamylamine may cause dizziness, lightheadedness, or fainting, especially when rising from a sitting or lying position. These effects could potentially limit the ability to exercise safely. If you experience these symptoms, it is advisable to avoid strenuous activities and consult your healthcare provider for guidance.
Is Mecamylamine safe for the elderly?
Elderly patients may be more sensitive to the effects of Mecamylamine, particularly the risk of dizziness and fainting. It is important to monitor blood pressure closely and adjust the dosage carefully. Elderly patients should rise slowly from sitting or lying positions to minimize the risk of falls. Regular consultation with a healthcare provider is essential to ensure safe use.
Who should avoid taking Mecamylamine?
Mecamylamine is contraindicated in patients with coronary insufficiency, recent myocardial infarction, uremia, glaucoma, and hypersensitivity to the product. It should be used with caution in patients with renal insufficiency, cerebral or coronary arteriosclerosis, and those who have had a recent cerebral accident. Sudden discontinuation can lead to a return of hypertensive levels, potentially causing serious complications.
