Mavorixafor
Infections, Warts ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Mavorixafor
Summary
Mavorixafor is used to treat an immune disorder called WHIM syndrome. This condition reduces the body's ability to fight infections.
Mavorixafor works by blocking the CXCR4 receptor. This stops leukocytes from being retained in the bone marrow, increasing their circulation in the bloodstream and enhancing the body's ability to fight infections.
For adults and children over 12 years with a body weight over 50 kg, the recommended dose is 400 mg once daily. For those weighing 50 kg or less, the dose is 300 mg once daily. It should be taken on an empty stomach at least 30 minutes before food.
Common side effects include thrombocytopenia, rash, rhinitis, epistaxis, vomiting and dizziness. Serious side effects include unusual bruising or bleeding and nosebleeds.
Mavorixafor should not be used during pregnancy as it can cause fetal harm. It should also be avoided with strong CYP3A4 inhibitors and inducers, and supplements like St. John's Wort. It may increase the risk of side effects if taken with drugs metabolized by CYP2D6 and CYP3A4. It's not recommended for breastfeeding mothers.
Indications and Purpose
How does Mavorixafor work?
Mavorixafor blocks the CXCR4 receptor, preventing leukocytes from being retained in the bone marrow. This increases their circulation in the bloodstream, enhancing the body's ability to fight infections.
Is Mavorixafor effective?
Mavorixafor's effectiveness was demonstrated in a 52-week study with patients having WHIM syndrome. It significantly increased neutrophil and lymphocyte counts and reduced infection rates compared to placebo.
What is Mavorixafor?
Mavorixafor is used to treat WHIM syndrome, an immune disorder that reduces the body's ability to fight infections. It works by increasing the number of neutrophils and lymphocytes, which are crucial for fighting infections.
Directions for Use
For how long do I take Mavorixafor?
Mavorixafor is typically used as a long-term treatment for WHIM syndrome. The duration of use depends on the individual's response and the doctor's recommendation.
How do I take Mavorixafor?
Take Mavorixafor once daily on an empty stomach, at least 30 minutes before breakfast. Avoid grapefruit products, as they can increase the risk of side effects.
How long does it take for Mavorixafor to start working?
Mavorixafor begins to increase neutrophil and lymphocyte counts within hours of dosing, with peak effects observed around 4 hours after administration.
How should I store Mavorixafor?
Store Mavorixafor in its original container, tightly closed, and in the refrigerator. Keep it out of reach of children and do not flush it down the toilet. Dispose of it through a take-back program if possible.
What is the usual dose of Mavorixafor?
For adults and children over 12 years with a body weight over 50 kg, the recommended dose is 400 mg once daily. For those weighing 50 kg or less, the dose is 300 mg once daily. Always take it on an empty stomach, at least 30 minutes before food.
Warnings and Precautions
Can I take Mavorixafor with other prescription drugs?
Mavorixafor interacts with strong CYP3A4 inhibitors, requiring a dose reduction. It also affects drugs metabolized by CYP2D6 and CYP3A4, potentially increasing their side effects. Avoid using it with strong CYP3A4 inducers.
Can Mavorixafor be taken safely while breastfeeding?
Breastfeeding is not recommended during treatment with Mavorixafor and for 3 weeks after the final dose due to the potential for serious adverse reactions in the breastfed child.
Can Mavorixafor be taken safely while pregnant?
Mavorixafor is expected to cause fetal harm and should not be used during pregnancy. Women of reproductive potential should use effective contraception during treatment and for 3 weeks after the final dose.
Is Mavorixafor safe for the elderly?
There is limited data on the use of Mavorixafor in patients aged 65 and older. It is important to monitor for side effects and consult a doctor for personalized advice.
Who should avoid taking Mavorixafor?
Mavorixafor can cause fetal harm, so it should not be used during pregnancy. It may also prolong the QTc interval, so caution is needed if taken with other QTc-prolonging drugs. Avoid grapefruit products and certain supplements like St. John's Wort.
