Lurasidone
Major Depressive Disorder, Bipolar Disorder ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Atypical Antipsychotic
Controlled Drug Substance
No
Lurasidone
Summary
Lurasidone is used to treat schizophrenia in adults and adolescents, as well as depressive episodes associated with bipolar I disorder in adults and children.
Lurasidone works by blocking certain receptors in the brain, specifically dopamine D2 and serotonin 5HT2A receptors. This helps to balance the activity of neurotransmitters in the brain, reducing symptoms such as hallucinations and mood swings.
For adults with schizophrenia, the usual starting dose is 40 mg once daily, with a range of 40 mg to 160 mg per day. For children with schizophrenia, the dose is typically 40 mg to 80 mg per day. For bipolar depression, adults may start with 20 mg to 60 mg per day and children may take 20 mg to 80 mg per day.
Common side effects of Lurasidone include drowsiness, nausea, and restlessness. Serious adverse effects can include a condition called neuroleptic malignant syndrome, involuntary movements (tardive dyskinesia), and metabolic changes.
Lurasidone should not be used with strong CYP3A4 inhibitors or inducers, as these can alter its effectiveness. It should also not be used by people who are allergic to it. Elderly patients with dementia-related psychosis treated with Lurasidone are at an increased risk of death. Lurasidone is not approved for this use.
Indications and Purpose
How does Lurasidone work?
Lurasidone works by affecting certain chemicals in the brain, specifically dopamine and serotonin, which are involved in mood regulation and perception. It helps balance these chemicals to reduce symptoms like mood swings, hallucinations, and depression. Think of it like adjusting the volume on a radio to get a clearer sound. By fine-tuning these brain chemicals, Lurasidone helps improve mental health conditions like schizophrenia and bipolar depression. Always follow your doctor's instructions for using Lurasidone.
Is Lurasidone effective?
Lurasidone is effective for treating mental health conditions like schizophrenia and bipolar depression. It works by affecting certain chemicals in the brain to help manage symptoms. Clinical studies show that Lurasidone improves mood, reduces hallucinations, and helps stabilize mood swings. These results support its effectiveness for the indicated conditions. Always follow your doctor's instructions and attend regular check-ups to monitor your progress and ensure the medication is working effectively for you.
What is Lurasidone?
Lurasidone is an antipsychotic medication used to treat mental health conditions like schizophrenia and bipolar depression. It works by affecting certain chemicals in the brain to help manage symptoms like mood swings, hallucinations, and depression. Lurasidone is usually used as part of a comprehensive treatment plan that includes therapy and lifestyle changes. It can be used alone or in combination with other medications, depending on your specific health needs. Always follow your doctor's instructions for using Lurasidone.
Directions for Use
For how long do I take Lurasidone?
Lurasidone is usually taken long-term for managing chronic mental health conditions like schizophrenia and bipolar depression. The duration of use depends on your response to the medication and your doctor's recommendations. It's important to take Lurasidone as prescribed and not stop without medical advice, as this could worsen your condition. Your doctor will regularly assess your treatment plan and make adjustments as needed. Always follow your healthcare provider's guidance for the best results.
How do I dispose of Lurasidone?
To dispose of Lurasidone, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. Always keep medications out of reach of children and pets.
How do I take Lurasidone?
Take Lurasidone once daily with food, usually in the evening. This helps your body absorb the medication better. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Avoid grapefruit and grapefruit juice, as they can interact with Lurasidone. Always follow your doctor's specific instructions for taking this medication.
How long does it take for Lurasidone to start working?
Lurasidone begins working in your body shortly after you take it, but you may not notice all the benefits right away. Some people experience improvements in symptoms within a few days, but it can take several weeks to achieve the full therapeutic effect. How quickly Lurasidone works can depend on individual factors like your condition, age, and overall health. It's important to take it exactly as prescribed and attend regular check-ups with your doctor to monitor your progress.
How should I store Lurasidone?
Store Lurasidone at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Lurasidone out of reach of children and pets to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication. Follow your pharmacist's instructions for safe storage.
What is the usual dose of Lurasidone?
The usual starting dose of Lurasidone for adults is 40 mg once daily, taken with food. Your doctor may adjust the dose based on your response and needs, with a maximum recommended dose of 160 mg per day. For children and the elderly, dose adjustments may be necessary, and careful monitoring is required. Always follow your doctor's specific dosing instructions for your health needs. Do not change your dose without consulting your healthcare provider.
Warnings and Precautions
Can I take Lurasidone with other prescription drugs?
Lurasidone has major interactions with strong CYP3A4 inhibitors, which are drugs that affect how your body processes Lurasidone. These interactions can increase the risk of adverse effects. Examples include certain antifungal medications and antibiotics. Lurasidone also interacts with other medications that cause drowsiness, increasing the risk of sedation. Always inform your doctor about all medications you are taking to avoid harmful interactions. They can help manage these interactions and adjust your treatment plan if necessary.
Can Lurasidone be taken safely while breastfeeding?
Lurasidone is not recommended while breastfeeding. Limited information is available on whether it passes into human breast milk. Animal studies suggest it may be excreted in milk, raising concerns about potential effects on the breastfed infant. The impact on milk supply is also unknown. If you're taking Lurasidone and want to breastfeed, discuss safer medication options with your doctor. They can help you choose a treatment that allows you to nurse your baby safely.
Can Lurasidone be taken safely while pregnant?
Lurasidone is not recommended during pregnancy unless the benefits outweigh the risks. Limited evidence is available on its safety during pregnancy. Animal studies suggest potential risks, but human data is lacking. Uncontrolled mental health conditions during pregnancy can pose risks to both mother and baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. They can help create a plan that protects both you and your baby.
Does Lurasidone have adverse effects?
Adverse effects are unwanted reactions to a medication. Lurasidone can cause adverse effects like nausea, dizziness, and sleepiness, which are common. Serious adverse effects include neuroleptic malignant syndrome, which is a severe reaction with symptoms like high fever and muscle stiffness, and tardive dyskinesia, which involves involuntary movements. If you experience any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Lurasidone and recommend appropriate actions to manage them.
Does Lurasidone have any safety warnings?
Yes, Lurasidone has important safety warnings. It may increase the risk of suicidal thoughts, especially in young adults. It can also cause neuroleptic malignant syndrome, which is a severe reaction with symptoms like high fever and muscle stiffness. Not adhering to these warnings can lead to serious health consequences. Always follow your doctor's advice and report any unusual symptoms immediately. Regular monitoring by your healthcare provider is essential to ensure safe use of Lurasidone.
Is it safe to drink alcohol while taking Lurasidone?
It's best to avoid alcohol while taking Lurasidone. Alcohol can increase the risk of side effects like dizziness and drowsiness, which can impair your ability to function safely. It may also worsen symptoms of your mental health condition. If you choose to drink occasionally, limit your alcohol intake and be aware of any warning signs like increased dizziness or mood changes. Always talk with your doctor about alcohol use while taking Lurasidone for personalized advice.
Is it safe to exercise while taking Lurasidone?
You can exercise while taking Lurasidone, but be mindful of potential side effects like dizziness or drowsiness, which may affect your exercise capacity. These symptoms can occur, especially when you start the medication. To exercise safely, start with light activities and gradually increase intensity. Stay hydrated and listen to your body. If you feel dizzy or unusually tired, stop and rest. Always consult your doctor if you have concerns about exercising while on Lurasidone.
Is it safe to stop Lurasidone?
It's not safe to stop Lurasidone suddenly without consulting your doctor. Lurasidone is usually used for long-term management of mental health conditions. Stopping it abruptly can cause your symptoms to return or worsen. Your doctor may suggest gradually reducing your dose to prevent withdrawal symptoms and ensure your condition remains stable. Always talk with your healthcare provider before making any changes to your medication regimen. They can help you safely adjust your treatment plan.
Is Lurasidone addictive?
Lurasidone is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Lurasidone works by affecting certain chemicals in the brain to help manage symptoms of mental health conditions. This mechanism does not lead to addiction. You won't experience cravings for Lurasidone or feel compelled to take more than prescribed. If you have concerns about medication dependence, discuss them with your doctor. They can provide reassurance and guidance for your treatment.
Is Lurasidone safe for the elderly?
Lurasidone can be used by the elderly, but they may be more vulnerable to side effects like dizziness and drowsiness. These effects can increase the risk of falls. Elderly patients may also have other health conditions or take multiple medications, which can affect Lurasidone's safety. Regular monitoring by a healthcare provider is important to ensure safe use. Dose adjustments may be necessary based on individual health needs. Always consult a doctor for personalized advice.
What are the most common side effects of Lurasidone?
Side effects are unwanted reactions that can occur with medication use. Common side effects of Lurasidone include nausea, dizziness, and sleepiness. These occur in more than 10% of users. It's important to note that side effects can vary from person to person. If you experience new symptoms after starting Lurasidone, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication. They can help determine if the side effects are related to Lurasidone and suggest ways to manage them.
Who should avoid taking Lurasidone?
Lurasidone should not be used if you are allergic to it or its ingredients. This is an absolute contraindication. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Lurasidone is also contraindicated with strong CYP3A4 inhibitors, which are drugs that affect how your body processes Lurasidone. Always inform your doctor about all medications you are taking to avoid harmful interactions. Consult your healthcare provider for personalized advice.
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