Lisdexamfetamine
Binge Drinking, Attention Deficit Disorder with Hyperactivity
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Central Nervous System Stimulant
Controlled Drug Substance
YES
Lisdexamfetamine
Summary
Lisdexamfetamine is used to treat attention deficit hyperactivity disorder (ADHD) in adults and children aged 6 years and older. It's also used to treat moderate to severe binge eating disorder in adults.
Lisdexamfetamine works by increasing the levels of certain chemicals in the brain that help improve attention, focus, and impulse control.
The recommended starting dose for adults and children aged 6 and older is 30 mg once daily in the morning. The dose can be increased gradually if needed, up to a maximum of 70 mg per day.
Common side effects include decreased appetite, insomnia, dry mouth, and weight loss. Other side effects can include increased heart rate, blood pressure, and psychiatric symptoms like hallucinations.
Lisdexamfetamine should not be used by individuals with a history of substance abuse, serious heart problems, or those taking MAO inhibitors. It's also not recommended for pregnant women or nursing mothers. Regular monitoring for cardiovascular and psychiatric symptoms is essential during treatment.
Indications and Purpose
How does Lisdexamfetamine work?
Lisdexamfetamine is a prodrug that is converted into dextroamphetamine in the body. It works by increasing the levels of neurotransmitters like dopamine and norepinephrine in the brain, which helps improve attention, focus, and impulse control.
Is Lisdexamfetamine effective?
Lisdexamfetamine has been shown to be effective in treating ADHD and binge eating disorder through multiple clinical trials. These studies demonstrate significant improvements in attention, impulse control, and reduction in binge eating episodes compared to placebo, supporting its efficacy.
What is Lisdexamfetamine?
Lisdexamfetamine is used to treat ADHD in children and adults, and binge eating disorder in adults. It works by affecting certain chemicals in the brain that contribute to hyperactivity and impulse control. As a central nervous system stimulant, it helps improve focus and reduce impulsive behavior.
Directions for Use
For how long do I take Lisdexamfetamine?
Lisdexamfetamine is typically used as part of a long-term treatment plan for ADHD or binge eating disorder. The duration of use can vary based on individual response and the doctor's assessment. Regular evaluations are recommended to determine the ongoing need for the medication.
How do I take Lisdexamfetamine?
Lisdexamfetamine should be taken once daily in the morning, with or without food. It can be swallowed whole or mixed with water, orange juice, or yogurt. There are no specific food restrictions, but avoid taking it in the afternoon or evening to prevent insomnia.
How long does it take for Lisdexamfetamine to start working?
Lisdexamfetamine typically starts working within a few hours after taking it. The effects can last throughout the day, helping to manage symptoms of ADHD or binge eating disorder effectively.
How should I store Lisdexamfetamine?
Store Lisdexamfetamine in a tightly closed container at room temperature, away from excess heat and moisture. Keep it out of reach of children and in a safe place to prevent misuse. Dispose of unused medication through a take-back program if available.
What is the usual dose of Lisdexamfetamine?
For adults, the recommended starting dose is 30 mg once daily in the morning, which can be increased in increments of 10 mg or 20 mg at weekly intervals up to a maximum of 70 mg per day. For children aged 6 years and older, the starting dose is also 30 mg once daily, with similar adjustments as needed.
Warnings and Precautions
Can I take Lisdexamfetamine with other prescription drugs?
Lisdexamfetamine can interact with MAO inhibitors, increasing the risk of hypertensive crisis. It may also interact with serotonergic drugs, increasing the risk of serotonin syndrome. Always inform your doctor of all medications you are taking to avoid potential interactions.
Can Lisdexamfetamine be taken safely while breastfeeding?
Lisdexamfetamine is excreted in human milk and may cause serious adverse reactions in nursing infants. Breastfeeding is not recommended during treatment with Lisdexamfetamine. Consult your doctor for advice on feeding options while on this medication.
Can Lisdexamfetamine be taken safely while pregnant?
Lisdexamfetamine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is limited data on its safety in pregnancy, and it may cause harm. Pregnant women should consult their doctor to weigh the risks and benefits.
Is it safe to exercise while taking Lisdexamfetamine?
Lisdexamfetamine does not specifically limit the ability to exercise. However, it can cause side effects like increased heart rate and blood pressure, which might affect physical activity. If you experience any unusual symptoms during exercise, consult your doctor.
Is Lisdexamfetamine safe for the elderly?
For elderly patients, Lisdexamfetamine is generally not recommended due to the increased risk of cardiovascular issues and other side effects. If prescribed, it should be used with caution, starting at the lower end of the dosing range, and with regular monitoring of heart and blood pressure.
Who should avoid taking Lisdexamfetamine?
Lisdexamfetamine has a high potential for abuse and dependence. It should not be used in individuals with a history of substance abuse, serious heart problems, or those taking MAO inhibitors. Regular monitoring for cardiovascular and psychiatric symptoms is essential during treatment.
