Linagliptin
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Dipeptidyl Peptidase 4 Inhibitor
Controlled Drug Substance
NO
Linagliptin
Learn more about this medicine -
Click HereSummary
Linagliptin is primarily used for treating type 2 diabetes. It helps to control blood sugar levels in combination with a healthy diet and regular exercise. It can be used alone or with other diabetes medications like metformin or insulin.
Linagliptin works by blocking an enzyme called DPP-4. This enzyme breaks down hormones that help control blood sugar levels. By inhibiting this enzyme, Linagliptin increases the levels of these hormones, which helps to lower blood sugar levels.
The usual daily dosage of Linagliptin for adults is 5 mg taken once a day. It can be taken with or without food. Always follow your doctor's instructions for proper dosage.
Common side effects of Linagliptin include stuffy or runny nose, sore throat, and headache. More serious side effects can include inflammation of the pancreas, allergic reactions, severe joint pain, and kidney problems. Always report any unusual symptoms to your doctor.
Linagliptin should be used with caution in people with a history of pancreatitis. It's also not recommended for individuals with known hypersensitivity to Linagliptin. People with severe kidney impairment should be monitored closely. Always consult a healthcare provider before starting treatment.
Indications and Purpose
How does Linagliptin work?
Linagliptin works by inhibiting the enzyme DPP-4, which breaks down incretin hormones. By preventing this breakdown, Linagliptin increases the levels of active incretin hormones, which stimulate insulin release and decrease glucagon levels in a glucose-dependent manner. This helps to improve blood sugar control in people with type 2 diabetes.
How does one know if Linagliptin is working?
The benefit of Linagliptin is evaluated by regularly monitoring blood sugar levels and glycosylated hemoglobin (HbA1c) to assess its effectiveness in controlling diabetes. Patients should have regular check-ups with their healthcare provider to adjust the treatment plan as needed and ensure optimal diabetes management.
Is Linagliptin effective?
Linagliptin has been shown to effectively lower blood sugar levels in adults with type 2 diabetes when used alongside diet and exercise. Clinical trials have demonstrated significant improvements in hemoglobin A1c (HbA1c) levels, fasting plasma glucose, and post-prandial glucose compared to placebo. It is effective as monotherapy or in combination with other diabetes medications.
What is Linagliptin?
Linagliptin is used to lower blood sugar levels in adults with type 2 diabetes, alongside diet and exercise. It belongs to a class of medications called DPP-4 inhibitors, which work by increasing the levels of incretin hormones. These hormones help regulate blood sugar by increasing insulin release and decreasing glucagon levels, improving glucose control.
What is Linagliptin used for?
Linagliptin is indicated for the treatment of type 2 diabetes mellitus in adults. It is used to improve glycemic control in conjunction with diet and exercise. Linagliptin is not recommended for type 1 diabetes or diabetic ketoacidosis.
Directions for Use
For how long do I take Linagliptin?
Linagliptin is typically used as a long-term treatment for managing type 2 diabetes. It should be taken continuously as prescribed by a healthcare provider, even if you feel well, to maintain blood sugar control.
How do I dispose of Linagliptin?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Linagliptin?
Linagliptin should be taken once daily, with or without food, at the same time each day. There are no specific food restrictions while taking Linagliptin, but it is important to follow a healthy diet and exercise plan as recommended by your healthcare provider to effectively manage diabetes.
How long does it take for Linagliptin to start working?
Linagliptin begins to work shortly after ingestion, with peak plasma concentrations occurring about 1.5 hours after a dose. However, it may take several weeks to see the full effect on blood sugar levels. Regular monitoring and follow-up with a healthcare provider are important to assess its effectiveness.
How should I store Linagliptin?
Store Linagliptin in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program or as advised by a pharmacist.
What is the usual dose of Linagliptin?
The usual daily dose of Linagliptin for adults is 5 mg taken orally once a day, with or without food. The safety and effectiveness of Linagliptin in children have not been established, so it is not recommended for pediatric use.
Warnings and Precautions
Can I take Linagliptin with other prescription drugs?
Linagliptin may interact with insulin and insulin secretagogues, increasing the risk of hypoglycemia. It can also interact with strong inducers of P-glycoprotein or CYP3A4 enzymes, such as rifampin, which may reduce its effectiveness. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Can I take Linagliptin with vitamins or supplements?
There are no confirmed interactions between Linagliptin and vitamins or supplements. There is no evidence that Linagliptin causes nutrient depletion or requires supplementation. However, it's important to inform your healthcare provider about all medications and supplements you are taking to ensure safe and effective use of Linagliptin. They can provide guidance on any potential interactions or monitoring needed.
Can Linagliptin be taken safely while breastfeeding?
There is no information on the presence of Linagliptin in human milk or its effects on the breastfed infant. It is present in rat milk, so caution is advised. Breastfeeding mothers should weigh the benefits of breastfeeding against the need for Linagliptin and any potential risks to the infant. Consulting a healthcare provider is recommended.
Can Linagliptin be taken safely while pregnant?
There is limited data on the use of Linagliptin during pregnancy, and its effects on fetal harm are not well established. It is generally recommended to avoid using Linagliptin during pregnancy unless the potential benefits outweigh the risks. Pregnant women should consult their healthcare provider to discuss the best treatment options for managing diabetes.
Does Linagliptin have adverse effects?
Adverse effects are unwanted or harmful effects caused by a medicine. Linagliptin may cause some adverse effects, such as runny nose, sore throat, cough, or diarrhea, which are not very common. Rarely, it can cause serious effects like pancreatitis, which is inflammation of the pancreas, and requires immediate medical attention. If you experience any new or unusual symptoms, it's important to talk to your healthcare provider before stopping the medicine.
Does Linagliptin have any safety warnings?
Linagliptin comes with safety warnings, including the risk of pancreatitis, which is inflammation of the pancreas. Symptoms to watch for include severe abdominal pain, nausea, and vomiting. If you experience these, seek medical attention immediately. Another warning is the potential for allergic reactions, which can cause rash, itching, or swelling. If you notice these symptoms, contact your doctor. It's important to monitor for these signs and report any new symptoms to your healthcare provider.
Is it safe to drink alcohol while taking Linagliptin?
Drinking alcohol can affect blood sugar levels, which may interfere with the effectiveness of Linagliptin in managing type 2 diabetes. It is important to discuss alcohol consumption with your healthcare provider to ensure safe use of Linagliptin.
Is it safe to exercise while taking Linagliptin?
Linagliptin does not typically limit the ability to exercise. However, managing blood sugar levels is important during physical activity. If you experience symptoms like dizziness or fatigue while exercising, consult your healthcare provider to ensure your diabetes management plan is appropriate.
Is it safe to stop Linagliptin?
Linagliptin is used for the long-term management of diabetes, a chronic condition. Stopping this medicine abruptly can lead to uncontrolled blood sugar levels, which may increase the risk of diabetes-related complications. There are no known withdrawal symptoms, but stopping without medical advice can be dangerous. Always consult your doctor before making any changes to your medication regimen.
Is Linagliptin addictive?
Linagliptin has no known potential for dependence or addiction. It is not habit-forming, and there are no behaviors or warning signs associated with physical or psychological dependence on this medicine. You can take Linagliptin as prescribed by your healthcare provider without worrying about addiction.
Is Linagliptin safe for the elderly?
Linagliptin is generally safe for use in the elderly without the need for dosage adjustment based on age. However, elderly patients should be monitored for any side effects, especially if they have other health conditions or are taking multiple medications. Regular check-ups with a healthcare provider are recommended to ensure safe and effective use.
What are the most common side effects of Linagliptin?
A side effect is an unwanted effect of a medicine. Common side effects of Linagliptin include runny nose, sore throat, cough, and diarrhea. These are not very common and may be coincidental or temporary. It's important to talk to your healthcare provider if you experience new symptoms, as they can help determine if they're related to the medicine or another cause. Always consult your doctor before stopping any medication.
Who should avoid taking Linagliptin?
Important warnings for Linagliptin include the risk of acute pancreatitis, severe allergic reactions, and hypoglycemia when used with insulin or sulfonylureas. It is contraindicated in patients with a history of hypersensitivity to Linagliptin or its ingredients. Patients should be aware of symptoms like severe abdominal pain, rash, or difficulty breathing and seek medical attention if they occur.
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