Levetiracetam
Partial Epilepsies, Myoclonic Epilepsy, Juvenile ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
undefined
Controlled Drug Substance
NO
Levetiracetam
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Click HereSummary
Levetiracetam is used to control different types of seizures, such as partial onset, myoclonic, and tonic-clonic seizures. It's also used off-label for conditions like bipolar disorder, schizophrenia, and migraine headaches.
Levetiracetam works by binding to a specific receptor in the brain. This helps control seizures by reducing the activity of certain chemicals in the brain and decreasing the release of glutamate, a chemical involved in seizures.
Levetiracetam is usually taken once or twice a day, with doses ranging from 500 mg to 3000 mg per day, depending on your condition and response. It can be taken orally or intravenously, and with or without food.
Common side effects of Levetiracetam include dizziness, drowsiness, fatigue, and nausea. More serious side effects can include skin reactions, aseptic meningitis, and decreased consciousness.
You should avoid alcohol and certain supplements while taking Levetiracetam. If you're pregnant, breastfeeding, or have kidney or liver problems, talk to your doctor before taking this medicine. It's also important not to stop taking Levetiracetam abruptly, as this can cause a rebound effect.
Indications and Purpose
What is Levetiracetam used for?
Levetiracetam is indicated for the treatment of seizure disorders such as partial onset, myoclonic, and tonic-clonic seizures. It may also be used off-label for bipolar disorder, schizophrenia, and migraine headaches.
How does Levetiracetam work?
Levetiracetam works by binding to a specific receptor in the brain, which helps to control seizures by reducing the activity of certain neurotransmitters and reducing the release of glutamate, a chemical that may be involved in seizures.
Is Levetiracetam effective?
Levetiracetam is an effective treatment for seizures, proven in clinical trials to reduce seizure frequency and severity. The medication is well tolerated with a low incidence of side effects, making it an important treatment option for epilepsy.
How does one know if Levetiracetam is working?
The benefit of Levetiracetam is checked or evaluated by monitoring seizure frequency and severity, using EEGs, and by having patients report any changes in symptoms. This allows healthcare providers to assess the effectiveness of the medication and make any necessary adjustments.
Directions for Use
What is the usual dose of Levetiracetam?
For adults, the usual starting dose of Levetiracetam is 1,000 mg per day, divided into two doses of 500 mg each. The dose can be increased by 1,000 mg every two weeks to a maximum of 3,000 mg per day. For children, the dose is weight-based. For example, children weighing more than 40 kg start with 1,000 mg per day, while those weighing 20-40 kg start with 500 mg per day. The dose can be increased every two weeks to a maximum of 3,000 mg per day.
How do I take Levetiracetam?
Levetiracetam can be taken with or without food, but patients should avoid alcohol and grapefruit juice, and be aware of any food allergies or sensitivities.
For how long do I take Levetiracetam?
Levetiracetam is typically used as a long-term treatment for seizure control. The duration of use depends on the individual's response to the medication and the underlying condition being treated. It is important to follow the healthcare provider's guidance and not to stop the medication abruptly without consulting them, as this can lead to increased seizure frequency.
How long does it take for Levetiracetam to start working?
Levetiracetam starts working within one to two hours, but may take several weeks or months to fully control seizures. Patients should continue taking the medication as prescribed and report any changes in symptoms to their doctor.
How should I store Levetiracetam?
Levetiracetam should be stored in a tightly closed container at room temperature, away from heat, moisture, and light. The medication should be kept out of reach of children and pets.
Warnings and Precautions
Who should avoid taking Levetiracetam?
Levetiracetam can cause drowsiness and dizziness, so patients should be cautious when driving or operating heavy machinery. It is also important for patients to avoid drinking alcohol while taking Levetiracetam. Patients with kidney or liver problems should be monitored closely for adverse effects. Levetiracetam should not be taken by patients who have a history of severe allergic reactions to the medication.
Can I take Levetiracetam with other prescription drugs?
Levetiracetam may interact with several prescription drugs, including other anticonvulsants, barbiturates, carbamazepine, and phenytoin. These interactions can affect the level of Levetiracetam in the body and increase the risk of adverse effects. Patients should inform their healthcare provider of any other medications they are taking.
Can I take Levetiracetam with vitamins or supplements?
Levetiracetam may interact with vitamin K, folic acid, and St. John's Wort, which can affect the levels of the medication in the body. Patients should avoid taking these supplements while taking Levetiracetam and should inform their healthcare provider of any other supplements they are taking.
Can Levetiracetam be taken safely while pregnant?
Levetiracetam may cause birth defects in unborn babies, so it is important for pregnant women to talk to their healthcare provider before taking the medication. The potential risks and benefits of Levetiracetam should be carefully weighed before deciding whether or not to take the medication during pregnancy.
Can Levetiracetam be taken safely while breastfeeding?
Levetiracetam is excreted in breast milk, so women who are breastfeeding should consult with their healthcare provider before taking the medication. The potential risks and benefits of Levetiracetam should be carefully weighed before deciding whether or not to take the medication while breastfeeding.
Is Levetiracetam safe for the elderly?
Elderly patients may have decreased renal function, which can affect the clearance of Levetiracetam. Therefore, it is important to adjust the dosage based on renal function and monitor the patient's response to the medication. No overall differences in safety were observed between elderly and younger subjects, but caution is advised due to the potential for impaired renal function in older adults.
Is it safe to exercise while taking Levetiracetam?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Is it safe to drink alcohol while taking Levetiracetam?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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