Lenvatinib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
lenvatinib
Summary
Lenvatinib is used to treat certain types of cancer, including thyroid cancer, which affects the thyroid gland in the neck, and renal cell carcinoma, which is a type of kidney cancer. It helps slow down the growth and spread of tumors.
Lenvatinib works by blocking proteins that help cancer cells grow and spread. This action slows down tumor growth and can even shrink tumors, making it harder for the cancer to progress.
Lenvatinib is usually taken as a capsule once daily, with or without food. The typical starting dose for adults is 24 mg per day, but your doctor may adjust this based on your response and any side effects.
Common side effects of Lenvatinib include high blood pressure, which is when the force of blood against artery walls is too high, fatigue, which means feeling very tired, and diarrhea, which is frequent loose or watery stools.
Lenvatinib can increase the risk of high blood pressure, liver problems, and heart issues. It should not be taken by people with severe liver impairment, which means the liver is not working well. Always follow your doctor's advice and report any unusual symptoms.
Indications and Purpose
How does Lenvatinib work?
Lenvatinib works by blocking proteins that help cancer cells grow and spread. Think of it like turning off a switch that powers cancer growth. This helps slow tumor growth and can shrink tumors. It's effective for certain cancers like thyroid cancer.
Is Lenvatinib effective?
Lenvatinib is effective in treating certain types of cancer, such as thyroid cancer and renal cell carcinoma. Clinical studies show it can slow tumor growth and improve survival rates. Your doctor will monitor your progress to ensure the medication is working effectively for you.
What is Lenvatinib?
Lenvatinib is a medication used to treat certain types of cancer, such as thyroid cancer and renal cell carcinoma. It works by blocking proteins that promote cancer cell growth. This helps slow tumor growth and spread. It's often used in combination with other therapies.
Directions for Use
For how long do I take Lenvatinib?
Lenvatinib is usually taken long-term for cancer treatment. The duration depends on your response and any side effects. Your doctor will monitor your progress and adjust your treatment as needed. Always follow your doctor's advice on how long to take Lenvatinib.
How do I dispose of Lenvatinib?
Dispose of Lenvatinib through a drug take-back program or at a pharmacy. If unavailable, mix it with undesirable substances like coffee grounds, seal in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take Lenvatinib?
Take Lenvatinib once daily, at the same time each day, with or without food. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Do not double up on doses. Follow your doctor's instructions regarding any dietary restrictions.
How long does it take for Lenvatinib to start working?
Lenvatinib starts working shortly after you take it, but noticeable effects may take weeks. The full therapeutic effect can take months. How quickly it works depends on your overall health and cancer type. Follow your doctor's instructions for the best results.
How should I store Lenvatinib?
Store Lenvatinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in humid places like bathrooms. Always keep it out of children's reach to prevent accidental ingestion.
What is the usual dose of Lenvatinib?
The usual starting dose of Lenvatinib for adults is 24 mg once daily. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 24 mg daily. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can I take Lenvatinib with other prescription drugs?
Lenvatinib can interact with medications that affect liver enzymes, such as CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) or inducers (e.g., rifampin), altering its effectiveness. It may also interact with other cancer treatments, anticoagulants (like warfarin), and antihypertensive drugs, increasing the risk of bleeding or affecting blood pressure. Always inform your doctor of all medications being taken.
Can Lenvatinib be taken safely while breastfeeding?
Lenvatinib is not recommended while breastfeeding. It's unclear if it passes into human milk, but it could pose risks to a baby's developing organs. Discuss safer medication options with your doctor if you wish to breastfeed.
Can Lenvatinib be taken safely while pregnant?
Lenvatinib is not recommended during pregnancy due to potential harm to the unborn baby. Limited human data is available, but animal studies show risks. If you're pregnant or planning to become pregnant, discuss safer treatment options with your doctor.
Does Lenvatinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Lenvatinib include high blood pressure and fatigue. Serious effects can include liver problems and heart issues. If you notice any new or worsening symptoms, contact your doctor immediately.
Does Lenvatinib have any safety warnings?
Yes, Lenvatinib has important safety warnings. It can increase the risk of high blood pressure, liver problems, and heart issues. Not following these warnings can lead to serious health problems. Always adhere to your doctor's advice and report any unusual symptoms immediately.
Is it safe to drink alcohol while taking Lenvatinib?
It's best to avoid alcohol while taking Lenvatinib. Alcohol can worsen side effects like high blood pressure and liver problems. If you choose to drink, limit your intake and watch for symptoms like dizziness or nausea. Consult your doctor for personalized advice.
Is it safe to exercise while taking Lenvatinib?
You can exercise while taking Lenvatinib, but be cautious. It can cause fatigue and high blood pressure, which might affect your exercise capacity. Stay hydrated and avoid strenuous activities if you feel dizzy or weak. Consult your doctor for personalized advice.
Is it safe to stop Lenvatinib?
Stopping Lenvatinib suddenly can worsen your condition. It's used for long-term treatment of cancer. Always consult your doctor before stopping. They may suggest a gradual reduction or alternative treatment to manage your condition safely.
Is Lenvatinib addictive?
Lenvatinib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms. This medication works by targeting cancer cells and does not affect brain chemistry in ways that could lead to addiction. You can feel confident that Lenvatinib doesn't carry this risk.
Is Lenvatinib safe for the elderly?
Lenvima has been shown to be safe and effective for patients over 65, but those over 75 may experience reduced tolerance to the medication. It is important to inform your doctor about any surgeries you are planning and to maintain good oral hygiene while taking Lenvima.
What are the most common side effects of Lenvatinib?
Side effects are unwanted reactions to a medication. Common side effects of Lenvatinib include high blood pressure, fatigue, and diarrhea. These effects vary from person to person. If you notice new symptoms, they might be temporary or unrelated to the medication. Consult your doctor before stopping any medication.
Who should avoid taking Lenvatinib?
Do not take Lenvatinib if you are allergic to it or its ingredients. It is contraindicated in patients with severe liver impairment. Use caution if you have high blood pressure or heart problems. Always consult your doctor about any concerns.
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