Labetalol
Malignant Hypertension, Angina Pectoris ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Beta-Adrenergic Blocker
Controlled Drug Substance
NO
Labetalol
Learn more about this medicine -
Click HereSummary
Labetalol is primarily used to manage hypertension, or high blood pressure.
Labetalol works in two ways: it slows your heart rate and relaxes your blood vessels, making it easier for your heart to pump blood.
Labetalol is taken orally, typically as a long-term medication. Doctors usually start adults on a low dose of 100mg and slowly increase it until the blood pressure is controlled. The typical daily dose is between 200mg and 400mg.
Common side effects of Labetalol include dizziness, tiredness, and nausea. It can also cause headaches, upset stomach, and stuffy nose. In rare cases, it can cause serious reactions like rash or trouble breathing.
Labetalol is not safe for people with asthma, serious heart problems, low blood pressure, or severe liver or kidney disease. It's important not to stop taking it suddenly. Always consult your doctor before making any changes to your medication regimen.
Indications and Purpose
What is Labetalol used for?
Labetalol is primarily indicated for the management of hypertension, which is high blood pressure. It can be used alone or in combination with other antihypertensive agents. Additionally, Labetalol is sometimes used to treat angina chest pain and to manage blood pressure in patients with pheochromocytoma, a type of tumor that can cause high blood pressure.
How does Labetalol work?
Labetalol works by blocking both alpha and beta adrenergic receptors. This dual action relaxes blood vessels and slows the heart rate, which improves blood flow and reduces blood pressure. By decreasing the workload on the heart, Labetalol helps prevent complications associated with high blood pressure, such as heart attacks and strokes.
Is Labetalol effective?
Labetalol is effective in managing high blood pressure by blocking alpha and beta receptors, which relaxes blood vessels and slows heart rate. Clinical studies have shown that Labetalol reduces blood pressure without significantly affecting heart rate, making it a reliable option for treating hypertension. It is often used alone or in combination with other antihypertensive agents.
How does one know if Labetalol is working?
The benefit of Labetalol is evaluated by regularly monitoring blood pressure to ensure it is within the target range. Your doctor may also order laboratory tests to check your body's response to the medication. It's important to keep all appointments with your healthcare provider to assess the effectiveness and adjust the dosage if necessary.
Directions for Use
What is the usual dose of Labetalol?
For adults, the usual starting dose of Labetalol is 100 mg twice daily, which can be increased based on the patient's response. The typical maintenance dose ranges from 200 to 400 mg daily, but in severe cases, it can go up to 2400 mg per day. For children, the safety and effectiveness of Labetalol have not been established, so it is not typically prescribed for pediatric use.
How do I take Labetalol?
Labetalol should be taken by mouth, usually two or three times a day, with or without food. Taking it with food may help reduce stomach upset. There are no specific food restrictions, but it's important to follow your healthcare provider's instructions and maintain a healthy diet to help manage blood pressure.
For how long do I take Labetalol?
Labetalol is typically used as a long-term treatment for managing high blood pressure. It is important to continue taking it even if you feel well, as it controls blood pressure but does not cure it. The duration of use should be determined by your healthcare provider based on your specific condition and response to the medication.
How long does it take for Labetalol to start working?
Labetalol begins to work within 1 to 2 hours after oral administration, with peak effects occurring within 2 to 4 hours. The duration of its effect depends on the dose, lasting at least 8 hours for a 100 mg dose and more than 12 hours for a 300 mg dose. Steady-state blood pressure response is typically achieved within 24 to 72 hours of regular dosing.
How should I store Labetalol?
Labetalol should be stored in its original container, tightly closed, and kept out of reach of children. It should be stored at room temperature, away from excess heat and moisture, and not in the bathroom. Proper storage ensures the medication remains effective and safe to use.
Warnings and Precautions
Who should avoid taking Labetalol?
Labetalol is contraindicated in patients with asthma, overt cardiac failure, severe bradycardia, and certain heart blocks. It should be used cautiously in patients with liver or kidney disease, diabetes, and those with a history of severe allergic reactions. Abrupt discontinuation can lead to serious heart problems, so dosage should be reduced gradually under medical supervision.
Can I take Labetalol with other prescription drugs?
Labetalol can interact with several medications, including cimetidine, which increases its bioavailability, and tricyclic antidepressants, which may cause tremors. It can also interact with other antihypertensive agents, potentially leading to excessive blood pressure reduction. Patients should inform their healthcare provider of all medications they are taking to avoid adverse interactions.
Can I take Labetalol with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Labetalol be taken safely while pregnant?
Labetalol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It crosses the placental barrier and may cause fetal distress, such as bradycardia and hypoglycemia. Pregnant women should consult their healthcare provider to weigh the risks and benefits before using Labetalol.
Can Labetalol be taken safely while breastfeeding?
Labetalol is excreted in small amounts in breast milk. While it is generally considered safe, caution is advised. Breastfeeding mothers should consult their healthcare provider to discuss the potential risks and benefits of using Labetalol while nursing, and monitor the infant for any adverse effects.
Is Labetalol safe for the elderly?
Elderly patients may be more sensitive to the effects of Labetalol, particularly the risk of orthostatic hypotension, dizziness, or lightheadedness. It is recommended to start treatment at a lower dose and adjust gradually. Elderly patients should be monitored closely for side effects, and any symptoms should be reported to a healthcare provider promptly.
Is it safe to exercise while taking Labetalol?
Labetalol may cause dizziness or lightheadedness, especially when you first start taking it or when your dose is increased. These side effects can affect your ability to exercise safely. It's important to get up slowly from sitting or lying positions to reduce the risk of dizziness. If you experience any side effects that affect your ability to exercise, consult your healthcare provider.
Is it safe to drink alcohol while taking Labetalol?
Drinking alcohol while taking Labetalol can increase the risk of side effects such as dizziness and lightheadedness. Alcohol can also enhance the blood pressure-lowering effects of Labetalol, which might lead to an increased risk of hypotension. Therefore, it is advisable to limit alcohol consumption and consult with a healthcare provider for personalized advice.
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