Ibrexafungerp

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Approved Treatment Indication:

Vulvovaginal Candidiasis

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Summary

What conditions is Ibrexafungerp used for?
Ibrexafungerp is an antifungal medication used to treat vaginal yeast infections in adults and adolescents. It's also used to reduce the recurrence of these infections.
How does Ibrexafungerp work in the body?
Ibrexafungerp works by inhibiting glucan synthase, an enzyme involved in forming the fungal cell wall. This effectively stops the growth of fungi that cause infections.
What are the usual dosages and routes of administration for Ibrexafungerp?
The usual dose for adults and postmenarchal pediatric females is 300 mg, two 150 mg tablets taken approximately 12 hours apart for one day. For reducing recurrent infections, the same dosage is taken monthly for six months.
What are the most commonly observed adverse effects of Ibrexafungerp?
Common side effects of Ibrexafungerp include diarrhea, nausea, abdominal pain, dizziness, and vomiting. If you experience any unusual symptoms or if these symptoms persist, consult your doctor.
What are important safety warnings and contraindications for Ibrexafungerp?
Ibrexafungerp should not be used during pregnancy due to the risk of fetal harm. Women of reproductive potential should use effective contraception during treatment and for 4 days after the last dose. Ibrexafungerp may interact with certain medications and supplements, so always inform your doctor about what you're taking.

Government Approvals

US(FDA)

WHO Essential Medicine

NO

Known Teratogen

No

Pharmaceutical Class

Triterpenoid Antifungal

Controlled Drug Substance

No

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Drug Ingredient

Ibrexafungerp

Summary

What conditions is Ibrexafungerp used for?
Ibrexafungerp is an antifungal medication used to treat vaginal yeast infections in adults and adolescents. It's also used to reduce the recurrence of these infections.
How does Ibrexafungerp work in the body?
Ibrexafungerp works by inhibiting glucan synthase, an enzyme involved in forming the fungal cell wall. This effectively stops the growth of fungi that cause infections.
What are the usual dosages and routes of administration for Ibrexafungerp?
The usual dose for adults and postmenarchal pediatric females is 300 mg, two 150 mg tablets taken approximately 12 hours apart for one day. For reducing recurrent infections, the same dosage is taken monthly for six months.
What are the most commonly observed adverse effects of Ibrexafungerp?
Common side effects of Ibrexafungerp include diarrhea, nausea, abdominal pain, dizziness, and vomiting. If you experience any unusual symptoms or if these symptoms persist, consult your doctor.
What are important safety warnings and contraindications for Ibrexafungerp?
Ibrexafungerp should not be used during pregnancy due to the risk of fetal harm. Women of reproductive potential should use effective contraception during treatment and for 4 days after the last dose. Ibrexafungerp may interact with certain medications and supplements, so always inform your doctor about what you're taking.

Indications and Purpose

How does Ibrexafungerp work?

Ibrexafungerp inhibits glucan synthase, an enzyme involved in forming the fungal cell wall, effectively stopping the growth of fungi that cause infections.

Is Ibrexafungerp effective?

Clinical trials have shown that Ibrexafungerp is effective in treating vaginal yeast infections and reducing recurrent infections. Patients experienced significant improvement in symptoms compared to placebo.

What is Ibrexafungerp?

Ibrexafungerp is an antifungal medication used to treat and reduce recurrent vaginal yeast infections in adults and adolescents. It works by stopping the growth of fungi that cause infections.

Directions for Use

For how long do I take Ibrexafungerp?

Ibrexafungerp is typically taken as a single-day treatment for vaginal yeast infections. For reducing recurrent infections, it is taken once a month for six months.

How do I take Ibrexafungerp?

Ibrexafungerp is taken as two doses approximately 12 hours apart, with or without food. There are no specific food restrictions, but always follow your doctor's instructions.

How should I store Ibrexafungerp?

Store Ibrexafungerp at room temperature, between 68°F to 77°F (20°C to 25°C), in its original container, tightly closed, and out of reach of children. Keep it away from excess heat and moisture.

What is the usual dose of Ibrexafungerp?

The usual dose for adults and post-menarchal pediatric females is 300 mg (two 150 mg tablets) taken approximately 12 hours apart for one day, totaling 600 mg. For reducing recurrent infections, the same dosage is taken monthly for six months.

Warnings and Precautions

Can Ibrexafungerp be taken safely while breastfeeding?

There is no data on the presence of Ibrexafungerp in human milk. The benefits of breastfeeding should be weighed against the mother's need for the medication and any potential risks to the infant.

Can Ibrexafungerp be taken safely while pregnant?

Ibrexafungerp is contraindicated during pregnancy due to the risk of fetal harm, as shown in animal studies. Women of reproductive potential should use effective contraception during treatment and for 4 days after the last dose.

Can I take Ibrexafungerp with other prescription drugs?

Ibrexafungerp interacts with strong CYP3A inhibitors, which can increase its concentration. Avoid using it with strong and moderate CYP3A inducers as they may reduce its effectiveness. Always inform your doctor about all medications you are taking.

Is Ibrexafungerp safe for the elderly?

There is no specific guidance for elderly patients, but clinical studies did not include enough subjects aged 65 and older to determine if they respond differently. Always consult a doctor for personalized advice.

Who should avoid taking Ibrexafungerp?

Ibrexafungerp is contraindicated in pregnancy due to the risk of fetal harm. Women of reproductive potential should use effective contraception during treatment and for 4 days after the last dose. It is also contraindicated in patients with hypersensitivity to the drug.