Ibandronate
Postmenopausal Osteoporosis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Bisphosphonate
Controlled Drug Substance
No
Ibandronate
Summary
Ibandronate is used to prevent and treat osteoporosis in postmenopausal women. It helps to increase bone density and reduce the risk of fractures.
Ibandronate works by inhibiting the activity of osteoclasts, which are cells responsible for bone resorption. This action reduces bone turnover, leading to a net gain in bone mass and increased bone density.
Ibandronate is typically prescribed as a 2.5 mg tablet taken once daily or a 150 mg tablet taken once monthly for adults. It is taken orally, on an empty stomach, with a full glass of plain water.
Common side effects of Ibandronate include nausea, stomach pain, diarrhea, constipation, weakness, dizziness, and headache. Serious adverse effects can include new or worsening heartburn, difficulty swallowing, upper chest pain, and severe bone, joint, or muscle pain.
Important warnings for Ibandronate include the risk of esophageal irritation, hypocalcemia, severe bone, joint, or muscle pain, and osteonecrosis of the jaw. Contraindications include abnormalities of the esophagus, inability to stand or sit upright for at least 60 minutes, hypocalcemia, and known hypersensitivity to Ibandronate.
Indications and Purpose
How does Ibandronate work?
Ibandronate works by binding to bone tissue and inhibiting the activity of osteoclasts, the cells responsible for bone resorption. This action helps to slow down bone loss, increase bone density, and reduce the risk of fractures in individuals with osteoporosis.
Is Ibandronate effective?
Ibandronate has been shown to increase bone mineral density and reduce the incidence of vertebral fractures in postmenopausal women with osteoporosis. Clinical trials have demonstrated its effectiveness in both daily and monthly dosing regimens, with significant improvements in bone density and reductions in fracture risk.
What is Ibandronate?
Ibandronate is used to prevent and treat osteoporosis in postmenopausal women. It belongs to a class of medications called bisphosphonates, which work by preventing bone breakdown and increasing bone density. This helps to reduce the risk of fractures in individuals with weakened bones.
Directions for Use
For how long do I take Ibandronate?
The optimal duration of Ibandronate use has not been determined. However, patients at low risk for fracture may consider discontinuing the drug after 3 to 5 years of use. It is important to have regular evaluations with your doctor to determine the need for continued therapy.
How do I take Ibandronate?
Ibandronate should be taken on an empty stomach with a full glass of plain water, at least 60 minutes before any food, drink, or other medications. It should not be taken with mineral water, coffee, tea, juice, or milk, as these can interfere with its absorption. After taking Ibandronate, wait at least 60 minutes before eating or drinking anything other than water.
How long does it take for Ibandronate to start working?
Ibandronate begins to work on bone tissue shortly after administration, but it may take several months to see significant improvements in bone density. Patients should continue taking the medication as prescribed and have regular check-ups to monitor their progress.
How should I store Ibandronate?
Ibandronate should be stored in its original container, tightly closed, at room temperature, away from excess heat and moisture. It should be kept out of reach of children. Unneeded medication should be disposed of through a take-back program, not flushed down the toilet.
What is the usual dose of Ibandronate?
For adults, Ibandronate is typically prescribed as a 150 mg tablet taken once a month. There is also a 2.5 mg tablet that is taken daily, but this is less common. Ibandronate is not recommended for use in children, and there is no established dosage for pediatric patients.
Warnings and Precautions
Can Ibandronate be taken safely while breastfeeding?
Ibandronate is not recommended for use while breastfeeding. There is no information on whether it passes into human milk, and its effects on a breastfed infant are unknown. Women who are breastfeeding should consult their doctor for advice on alternative treatments.
Can Ibandronate be taken safely while pregnant?
Ibandronate is not recommended for use during pregnancy. There is no data on its effects in pregnant women, and animal studies have shown potential risks. Women who are pregnant or planning to become pregnant should discuss alternative treatments with their doctor.
Can I take Ibandronate with other prescription drugs?
Significant drug interactions with Ibandronate include aspirin and other NSAIDs, which can increase gastrointestinal irritation. Calcium supplements, antacids, and other medications containing multivalent cations should be taken at least 60 minutes after Ibandronate to avoid interference with absorption.
Is Ibandronate safe for the elderly?
Ibandronate is generally safe for use in the elderly, but greater sensitivity in some older individuals cannot be ruled out. It is important for elderly patients to have regular check-ups to monitor their response to the medication and adjust the treatment as necessary.
Is it safe to exercise while taking Ibandronate?
Ibandronate does not specifically limit the ability to exercise. However, if you experience severe bone, joint, or muscle pain, which can occur with this medication, it may affect your ability to exercise. If you experience such pain, contact your doctor for advice.
Who should avoid taking Ibandronate?
Important warnings for Ibandronate include the risk of esophageal irritation, hypocalcemia, severe bone, joint, or muscle pain, and osteonecrosis of the jaw. Contraindications include abnormalities of the esophagus, inability to sit or stand upright for at least 60 minutes, and known hypersensitivity to the drug. Patients should also be cautious if they have severe renal impairment.
