Hyoscine
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Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Anticholinergic
Controlled Drug Substance
YES
Hyoscine
Summary
Hyoscine is used to relieve spasms associated with Irritable Bowel Syndrome. It helps to ease the discomfort in the gastrointestinal tract.
Hyoscine works by exerting a spasmolytic action on the smooth muscle of the gastrointestinal, biliary and genitourinary tracts. It acts as a peripheral anticholinergic agent, blocking certain nerve transmissions within the visceral wall.
For adults and children aged 12 years or over, the recommended starting dose is 1 Hyoscine tablet three times daily. If necessary, this can be increased to 2 tablets four times daily. Hyoscine is not recommended for children under 12 years.
Common side effects of Hyoscine include dry mouth and skin reactions. Serious adverse effects include anaphylactic shock and urinary retention, though their frequency is not known.
Hyoscine is not recommended during pregnancy or breastfeeding. It should not be taken by patients with hypersensitivity to its components, myasthenia gravis, mechanical stenosis in the gastrointestinal tract, paralytic or obstructive ileus, megacolon and narrow-angle glaucoma. It should be used with caution in conditions characterized by tachycardia.
Indications and Purpose
How does Hyoscine work?
Hyoscine works by exerting a spasmolytic action on the smooth muscle of the gastrointestinal, biliary, and genito-urinary tracts. It acts as a peripheral anticholinergic agent, blocking ganglionic transmission within the visceral wall and exhibiting anti-muscarinic activity.
Is Hyoscine effective?
Hyoscine is indicated for the relief of spasm of the gastrointestinal tract associated with medically confirmed Irritable Bowel Syndrome. It works by exerting a spasmolytic action on the smooth muscle of the gastrointestinal, biliary, and genito-urinary tracts.
What is Hyoscine?
Hyoscine is used to relieve spasms of the gastrointestinal tract associated with Irritable Bowel Syndrome. It works by exerting a spasmolytic action on the smooth muscle of the gastrointestinal, biliary, and genito-urinary tracts. As a quaternary ammonium derivative, it does not enter the central nervous system, minimizing central anticholinergic side effects.
Directions for Use
For how long do I take Hyoscine?
Hyoscine should not be taken on a continuous daily basis or for extended periods without investigating the cause of abdominal pain. Consult a doctor if symptoms persist or worsen.
How do I take Hyoscine?
Hyoscine can be taken with or without food. There are no specific food restrictions mentioned, but patients should follow their doctor's advice regarding diet and medication use.
How should I store Hyoscine?
Hyoscine does not require any special storage conditions. However, it should be stored in its original packaging to protect it from moisture and light.
What is the usual dose of Hyoscine?
For adults and children aged 12 years or over, the recommended starting dose is 1 hyoscine tablet three times daily. If necessary, this can be increased to 2 tablets four times daily. Hyoscine is not recommended for children under 12 years.
Warnings and Precautions
Can Hyoscine be taken safely while breastfeeding?
There is insufficient information on the excretion of Hyoscine in human milk, and a risk to the breastfeeding child cannot be excluded. Therefore, the use of Hyoscine during breastfeeding is not recommended.
Can Hyoscine be taken safely while pregnant?
There are limited data on the use of Hyoscine in pregnant women, and animal studies are insufficient regarding reproductive toxicity. As a precaution, Hyoscine is not recommended during pregnancy.
Can I take Hyoscine with other prescription drugs?
Hyoscine may intensify the anticholinergic effects of drugs like tri- and tetracyclic antidepressants, antihistamines, and antipsychotics. It may also diminish the effects of dopamine antagonists like metoclopramide and enhance the tachycardic effects of beta-adrenergic agents.
Is Hyoscine safe for the elderly?
There is no specific information on the use of Hyoscine in the elderly. Clinical trials have included patients over 65 years, and no adverse reactions specific to this age group have been reported. However, caution is advised, and medical advice should be sought if any unusual symptoms occur.
Is it safe to exercise while taking Hyoscine?
Hyoscine does not specifically limit the ability to exercise. However, if you experience any side effects that affect your physical performance, consult your doctor for advice.
Who should avoid taking Hyoscine?
Hyoscine is contraindicated in patients with hypersensitivity to its components, myasthenia gravis, mechanical stenosis in the gastrointestinal tract, paralytic or obstructive ileus, megacolon, and narrow-angle glaucoma. It should be used with caution in conditions characterized by tachycardia and in patients susceptible to intestinal or urinary outlet obstructions.
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