Hydrocodone
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Opioid Agonist
Controlled Drug Substance
YES
Hydrocodone
Summary
Hydrocodone is used for managing severe and persistent pain that requires long-term treatment, especially when other pain medications are inadequate.
Hydrocodone works by binding to opioid receptors in the brain and nervous system. This changes the way the brain and body perceive pain, providing relief.
The usual daily dose for adults varies based on the formulation and patient's condition. For extended-release tablets, the starting dose is typically 20 mg every 24 hours. It is not typically recommended for children due to serious side effects.
Common side effects include nausea, vomiting, constipation, dizziness, and drowsiness. Serious side effects can include respiratory depression, addiction, and overdose.
Hydrocodone should not be used in patients with significant respiratory depression, severe asthma, or known gastrointestinal obstruction. It carries risks of addiction, abuse, and misuse, which can lead to overdose and death. Alcohol and other CNS depressants should be avoided.
Indications and Purpose
How does Hydrocodone work?
Hydrocodone works by binding to opioid receptors in the brain and nervous system, altering the perception of pain and providing relief. It changes the way the brain and body respond to pain signals, making it effective for managing severe pain.
Is Hydrocodone effective?
Hydrocodone is an opioid analgesic that effectively manages severe and persistent pain by altering the way the brain and nervous system respond to pain. Clinical trials have demonstrated its efficacy in providing pain relief for patients who require long-term opioid treatment.
What is Hydrocodone?
Hydrocodone is an opioid analgesic used to manage severe and persistent pain that requires long-term treatment. It works by altering the way the brain and nervous system respond to pain, providing effective relief for patients who cannot be treated with other pain medications.
Directions for Use
For how long do I take Hydrocodone?
Hydrocodone is typically used for managing severe and persistent pain that requires long-term treatment. The duration of use should be as short as possible, and the treatment plan should be regularly reviewed by a healthcare provider to minimize risks of addiction and side effects.
How do I take Hydrocodone?
Hydrocodone can be taken with or without food, but taking it with food may help reduce nausea. There are no specific food restrictions, but avoid alcohol and consult your doctor for personalized dietary advice while on this medication.
How long does it take for Hydrocodone to start working?
Hydrocodone typically begins to relieve pain within 30 to 60 minutes after oral administration. The onset of action may vary depending on the formulation and individual patient factors.
How should I store Hydrocodone?
Store Hydrocodone in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and in a location not easily accessible by others. Dispose of unused medication through a take-back program or by flushing it down the toilet.
What is the usual dose of Hydrocodone?
The usual daily dose of Hydrocodone for adults varies based on the formulation and the patient's condition. For extended-release tablets, the starting dose is typically 20 mg every 24 hours for opioid-naïve patients. For children, Hydrocodone is not typically recommended due to the risk of serious side effects. Always follow a doctor's prescription and guidance.
Warnings and Precautions
Can Hydrocodone be taken safely while breastfeeding?
Hydrocodone is present in breast milk and can cause serious adverse effects in a breastfed infant, including sedation and respiratory depression. Breastfeeding is not recommended during treatment with Hydrocodone. Consult your doctor for alternative pain management options.
Can Hydrocodone be taken safely while pregnant?
Hydrocodone use during pregnancy can lead to neonatal opioid withdrawal syndrome, which may be life-threatening. It should only be used if the benefits outweigh the risks. Pregnant women should consult their healthcare provider for personalized advice.
Can I take Hydrocodone with other prescription drugs?
Hydrocodone can interact with benzodiazepines, other CNS depressants, and CYP3A4 inhibitors, increasing the risk of respiratory depression and sedation. It is important to inform your doctor of all medications you are taking to avoid potentially dangerous interactions.
Is Hydrocodone safe for the elderly?
Elderly patients may be more sensitive to the effects of Hydrocodone, particularly respiratory depression and sedation. It is important to start with a lower dose and monitor closely for side effects. Regular evaluation by a healthcare provider is recommended to ensure safe use.
Is it safe to drink alcohol while taking Hydrocodone?
Drinking alcohol while taking Hydrocodone is not safe. Alcohol can increase the risk of serious side effects, including life-threatening respiratory depression, sedation, and coma. It is advised to avoid alcohol entirely during treatment with Hydrocodone.
Is it safe to exercise while taking Hydrocodone?
Hydrocodone can cause drowsiness, dizziness, and fatigue, which may limit your ability to exercise safely. It is important to assess how the medication affects you before engaging in physical activities. Consult your doctor for personalized advice on exercise while taking Hydrocodone.
Who should avoid taking Hydrocodone?
Hydrocodone carries risks of addiction, abuse, and misuse, which can lead to overdose and death. It should not be used in patients with significant respiratory depression, acute or severe asthma, or known gastrointestinal obstruction. Alcohol and other CNS depressants should be avoided.
