Gemfibrozil

Coronary Artery Disease, Hypercholesterolemia ... show more

Drug Status

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Government Approvals

US(FDA), UK(BNF)

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WHO Essential Medicine

NO

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Known Teratogen

No

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Pharmaceutical Class

Peroxisome Proliferator Receptor alpha Agonist

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Controlled Drug Substance

No

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Drug Ingredient

Gemfibrozil

Summary

  • Gemfibrozil is used to lower high levels of unhealthy fats in your blood, specifically triglycerides and VLDL cholesterol. It's prescribed for adults with certain types of high fat in their blood, particularly Types IV and V, who are at risk for pancreatitis and haven't been helped enough by diet alone. It can also help people with Type IIb high fat that increases heart disease risk.

  • Gemfibrozil works by reducing the production of fats in the liver and helps the body get rid of them more quickly. It also slows down the breakdown of fats in other parts of the body, preventing them from going to the liver and increasing triglyceride levels. In animal studies, it's also shown to help the liver remove cholesterol better and get rid of more cholesterol through waste.

  • For adults, the usual dose of Gemfibrozil is 600 mg taken twice a day, morning and evening, 30 minutes before meals. It is typically not recommended for children. Always consult with a healthcare provider for pediatric dosing if necessary.

  • Gemfibrozil can sometimes cause headaches, indigestion, heartburn, stomach pain, dizziness, and somnolence. Rarely, it can cause serious blood problems, so regular blood tests are needed to check for this. Your doctor will also monitor your liver.

  • Gemfibrozil can cause serious problems when taken with certain other medicines. It shouldn't be taken with simvastatin, repaglinide, or selexipag. If you're on warfarin, a blood thinner, you might need a lower dose if you also take gemfibrozil. Always consult your doctor before starting any new medication.

Indications and Purpose

How does Gemfibrozil work?

Gemfibrozil helps lower bad fats (triglycerides) in the blood in a few ways. It reduces the production of these fats in the liver and helps the body get rid of them more quickly. It also slows down the breakdown of fats in other parts of the body, preventing them from going to the liver and increasing triglyceride levels. In animal studies, it's also shown to help the liver remove cholesterol better and get rid of more cholesterol through waste.

Is Gemfibrozil effective?

Gemfibrozil is a medicine to help lower certain unhealthy fats in the blood. It works well for some people with high cholesterol who *don't* have heart disease. However, studies haven't shown it helps people who *already have* heart disease live longer or have fewer heart problems. The results of one big study were unclear on this point.

What is Gemfibrozil?

Gemfibrozil is a medicine that helps lower bad cholesterol and raise good cholesterol. It's used for a specific type of high cholesterol. Before taking it, you should try to improve your cholesterol through diet, exercise, and weight loss. Your doctor will check your cholesterol levels regularly while you're on the medicine. If it's not working after three months, they might stop your prescription.

Directions for Use

For how long do I take Gemfibrozil?

Gemfibrozil is a medicine to lower cholesterol. If your cholesterol hasn't improved enough after three months of taking it, your doctor will likely stop prescribing it. They might try a different medicine or treatment plan.

How do I dispose of Gemfibrozil?

If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.

How do I take Gemfibrozil?

Gemfibrozil should be taken 30 minutes before meals, twice a day. Swallow the tablet whole with water.

  • No specific food restrictions, but a low-fat diet is recommended.
  • Avoid alcohol while taking this medication.

Follow your doctor's instructions for personalized guidance.

How long does it take for Gemfibrozil to start working?

Gemfibrozil, a medicine, reaches its highest level in your blood within 1 to 2 hours after you take it. Half of the medicine is gone from your blood in about 1.5 hours after you've taken it regularly for a while. Taking it 30 minutes before meals helps your body absorb it better.

How should I store Gemfibrozil?

Gemfibrozil is a medicine that comes as a white pill. It's safe to store normally, and doctors prescribe it to be taken by mouth. Each pill contains 600 milligrams of the medicine.

What is the usual dose of Gemfibrozil?

For adults, the usual dose of Gemfibrozil is:

  • 600 mg taken twice a day (morning and evening), 30 minutes before meals.

For children, the use of Gemfibrozil is typically not recommended, and its safety and effectiveness in pediatric patients have not been established. Always consult with a healthcare provider for pediatric dosing if necessary.

Warnings and Precautions

Can Gemfibrozil be taken safely while breastfeeding?

Gemfibrozil is a medicine, and we don't know if it passes into breast milk. Since many medicines *do* pass into breast milk, and this medicine has shown some cancer risk in animal tests, there's a worry it could harm the baby. The doctor needs to weigh the importance of the medicine for the mother's health against the possible risk to the baby. They'll help decide whether to stop breastfeeding or stop taking the medicine.

Can Gemfibrozil be taken safely while pregnant?

Gemfibrozil is a medicine, and doctors only give it to pregnant women if the medicine's help to the mother is more important than any possible harm to the baby. We don't have enough information from studies on pregnant women to be sure how safe it is. Tests on animals showed some problems with babies born to mothers who took high doses of the medicine, including lower birth weight and bone problems. Because of these animal study results and the lack of human data, doctors are very cautious about using this medicine during pregnancy.

Can I take Gemfibrozil with other prescription drugs?

Gemfibrozil is a medicine that lowers cholesterol. It shouldn't be taken with certain other medications because it can make those other medicines stronger, leading to side effects. Specifically, combining it with simvastatin, repaglinide, or colchicine is risky. Using gemfibrozil with other cholesterol medicines like simvastatin increases the chance of muscle problems. If you need to take gemfibrozil and colestipol (another cholesterol medicine), take them at least two hours apart.

Does Gemfibrozil have adverse effects?

Yes, empagliflozin can have adverse effects, which are unwanted reactions to a medication. Most people tolerate it well, but some may experience urinary tract infections, which are infections in the system that removes urine from your body, affecting up to 9% of users. Genital yeast infections, especially in women, are common and cause itching and unusual discharge. The medication can increase urination, leading to dehydration, which means your body doesn't have enough fluids, causing dizziness. A rare but serious effect is ketoacidosis, which is a dangerous buildup of acid in your blood and requires immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking empagliflozin.

Does Gemfibrozil have any safety warnings?

Yes, empagliflozin has important safety warnings. It can increase the risk of diabetic ketoacidosis, which is a dangerous buildup of acids in the blood. This can occur even with normal blood sugar, especially if insulin doses are missed or during illness. Seek emergency help if you experience nausea, vomiting, stomach pain, or breathing problems. Empagliflozin can cause dehydration, which means the body lacks enough fluids, leading to low blood pressure or kidney issues. Drink plenty of water. Serious urinary tract infections, which affect the system removing urine, can occur. Watch for painful urination, fever, or back pain. Rarely, it can cause necrotizing fasciitis, a serious bacterial infection in the genital area. Genital yeast infections are common. Regular foot care is important as it may increase amputation risk. Stop taking the medicine and seek help if you develop signs of an allergic reaction.

Is Gemfibrozil addictive?

Empagliflozin is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Empagliflozin works by affecting your kidneys to help remove sugar through urine. This mechanism doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. Unlike some medications that can cause psychological or physical dependence, empagliflozin doesn't create these effects. If you have concerns about medication dependence, you can feel confident that empagliflozin doesn't carry this risk while managing your health condition.

Is Gemfibrozil safe for the elderly?

Gemfibrozil is a medicine, but it can cause muscle problems, especially in older people. This risk is even higher if they're also taking colchicine. If someone is also taking warfarin (a blood thinner), their warfarin dose needs to be lowered to avoid excessive bleeding.

Is it safe to drink alcohol while taking Gemfibrozil?

Drinking too much alcohol can raise your blood fats, specifically triglycerides. Doctors often want to get your alcohol use under control before starting medication for high triglycerides, because reducing alcohol intake can sometimes fix the problem on its own.

Is it safe to exercise while taking Gemfibrozil?

The medicine gemfibrozil can sometimes cause muscle pain, soreness, or weakness (myositis). If you experience any of these, stop taking the medicine and see a doctor right away. These muscle problems could make it hard to exercise.

Is it safe to stop Gemfibrozil?

No, it is not safe to stop empagliflozin suddenly. If you're using it for type 2 diabetes, stopping can cause your blood sugar levels to rise quickly. For heart failure, which is when your heart can't pump blood effectively, or kidney disease, which is damage to organs that filter waste from your blood, stopping could worsen these conditions. A dangerous complication called diabetic ketoacidosis might occur, causing harmful acids to build up in your blood, leading to nausea, vomiting, stomach pain, and breathing problems. This risk continues for several days after stopping. Always consult your doctor before stopping empagliflozin. They may suggest gradually reducing your dose or switching medications to keep your condition under control.

What are the most common side effects of Gemfibrozil?

Side effects are unwanted reactions that can happen when taking a medication. With empagliflozin, these effects vary from person to person. The most common side effect is urinary tract infections, which affect about 8-9% of people taking this medication. Women may experience genital yeast infections, which occur in about 2-5% of female patients. Men can also get genital yeast infections, but this happens less frequently. Some people notice they urinate more often when taking empagliflozin, which happens in about 1-3% of patients. Upper respiratory infections, which affect your nose, throat, and airways, occur in about 4% of people taking this medication. If you notice new symptoms after starting empagliflozin, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.

Who should avoid taking Gemfibrozil?

Gemfibrozil is a medication that can cause serious problems when taken with certain other medicines. It shouldn't be taken with simvastatin, repaglinide, or selexipag. Taking it with cholesterol-lowering drugs like simvastatin greatly increases the risk of muscle damage. If you're on warfarin (a blood thinner), you might need a lower dose of warfarin if you also take gemfibrozil. Finally, gemfibrozil can affect how your body processes some other medications, so your doctor might need to adjust the doses of those drugs.