Fostamatinib
Thrombocytopenia
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Fostamatinib
Summary
Fostamatinib is used to treat chronic immune thrombocytopenia, which is a condition where your immune system destroys platelets, leading to a low platelet count and increased risk of bleeding.
Fostamatinib works by inhibiting spleen tyrosine kinase, which is an enzyme involved in the immune system's attack on platelets. This action helps increase platelet counts and reduce the risk of bleeding.
The usual starting dose of Fostamatinib for adults is 100 mg taken twice daily. Your doctor may adjust your dose based on your response and any side effects. The maximum recommended dose is 150 mg twice daily.
Common side effects of Fostamatinib include diarrhea, high blood pressure, and changes in liver function. These effects vary from person to person and are usually mild to moderate.
Fostamatinib can increase the risk of high blood pressure and liver problems. It's not recommended for people with severe liver issues or during pregnancy. Regular monitoring of blood pressure and liver function is necessary.
Indications and Purpose
How does Fostamatinib work?
Fostamatinib works by inhibiting spleen tyrosine kinase, which is an enzyme involved in the immune system's attack on platelets. By blocking this enzyme, Fostamatinib reduces the destruction of platelets, helping to increase their count in the blood. This action helps manage chronic immune thrombocytopenia, reducing the risk of bleeding.
Is Fostamatinib effective?
Fostamatinib is effective for treating chronic immune thrombocytopenia, which is a condition where your immune system destroys platelets. Clinical studies show it increases platelet counts in many patients, reducing the risk of bleeding. Its effectiveness varies, so regular monitoring by your doctor is important to ensure it's working for you.
What is Fostamatinib?
Fostamatinib is a medication used to treat chronic immune thrombocytopenia, which is a condition where your immune system destroys platelets. It belongs to a class of drugs called spleen tyrosine kinase inhibitors, which work by reducing the immune system's attack on platelets. This helps increase platelet counts and reduce the risk of bleeding.
Directions for Use
For how long do I take Fostamatinib?
Fostamatinib is usually a long-term medication for managing chronic immune thrombocytopenia, which is a condition where your immune system destroys platelets. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Always talk with your doctor before changing or stopping your Fostamatinib treatment.
How do I dispose of Fostamatinib?
If you can, bring unused Fostamatinib to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Fostamatinib?
Take Fostamatinib as prescribed by your doctor, usually twice daily. You can take it with or without food. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow your doctor's advice on any dietary or beverage restrictions.
How long does it take for Fostamatinib to start working?
Fostamatinib begins working in your body shortly after you take it, but it may take several weeks to see significant improvements in platelet counts. The full therapeutic effect can take a few months. How quickly it works can depend on your overall health and response to the medication. Take it exactly as prescribed for the best results.
How should I store Fostamatinib?
Store Fostamatinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep it out of reach of children to prevent accidental swallowing. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Fostamatinib?
The usual starting dose of Fostamatinib for adults is 100 mg twice daily. Your doctor may adjust your dose based on your response and any side effects. The maximum recommended dose is 150 mg twice daily. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Fostamatinib be taken safely while breastfeeding?
Fostamatinib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. If you're taking Fostamatinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Fostamatinib be taken safely while pregnant?
Fostamatinib isn't recommended during pregnancy due to limited evidence on its safety. Animal studies suggest potential risks, but human data is lacking. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Can I take Fostamatinib with other prescription drugs?
Fostamatinib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. For example, it may interact with blood pressure medications, increasing the risk of high blood pressure. Always inform your doctor about all the medications you are taking to avoid potential interactions.
Does Fostamatinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Fostamatinib include diarrhea, high blood pressure, and liver function changes. These effects vary in frequency and severity. Serious side effects like severe liver problems require immediate medical attention. Always inform your doctor about any new or worsening symptoms.
Does Fostamatinib have any safety warnings?
Yes, Fostamatinib has important safety warnings. It can increase the risk of high blood pressure and liver problems. Regular monitoring of blood pressure and liver function is necessary. Not adhering to these warnings can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is Fostamatinib addictive?
Fostamatinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by affecting your immune system to reduce inflammation, not by altering brain chemistry. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Fostamatinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Fostamatinib, such as high blood pressure and liver problems. Regular monitoring is important to ensure safety. Discuss any concerns with your doctor, who can adjust your treatment plan based on your specific health needs.
Is it safe to drink alcohol while taking Fostamatinib?
It's best to avoid alcohol while taking Fostamatinib. Alcohol can increase the risk of liver problems, which is a concern with this medication. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or fatigue. Talk with your doctor about alcohol use while taking Fostamatinib.
Is it safe to exercise while taking Fostamatinib?
You can exercise while taking Fostamatinib, but be cautious. This medication can cause high blood pressure, which might affect your exercise capacity. Monitor for symptoms like dizziness or unusual fatigue. Drink plenty of water and avoid strenuous activities if you notice these symptoms. Consult your doctor for personalized advice.
Is it safe to stop Fostamatinib?
Stopping Fostamatinib suddenly can cause your condition to worsen. It's used for long-term management of chronic conditions like immune thrombocytopenia. Always talk with your doctor before stopping Fostamatinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
What are the most common side effects of Fostamatinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Fostamatinib include diarrhea, high blood pressure, and changes in liver function. These effects vary from person to person. If you notice new symptoms after starting Fostamatinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Fostamatinib?
Don't take Fostamatinib if you're allergic to it or its ingredients. It's not recommended for people with severe liver problems. Caution is needed if you have high blood pressure or are pregnant. Always consult your doctor about these concerns to ensure the benefits outweigh the risks.
