Fluvastatin
Coronary Artery Disease, Hypercholesterolemia ... show more
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
HMG-CoA Reductase Inhibitor
Controlled Drug Substance
No
Fluvastatin
Summary
Fluvastatin is used to lower high cholesterol and reduce triglycerides. It's often prescribed for people with hyperlipidemia or those at high risk of heart disease due to diabetes, hypertension, or smoking.
Fluvastatin works by blocking HMG-CoA reductase, an enzyme needed for cholesterol production in the liver. This reduces LDL (bad cholesterol), increases HDL (good cholesterol), and helps prevent cholesterol buildup in blood vessels.
The usual adult dose is 20 to 80 mg daily, either once at bedtime or divided into two doses. For children aged 10-16 years, the dose is 20-40 mg once daily.
Common side effects of Fluvastatin include muscle pain, headache, nausea, and fatigue. Rare but serious risks include liver damage, severe muscle breakdown, and kidney problems.
People with active liver disease, pregnant or breastfeeding women, and those with a history of statin-induced muscle problems should avoid Fluvastatin. It should also be used cautiously in people with kidney disease or alcohol dependence.
Indications and Purpose
How does Fluvastatin work?
Fluvastatin works by blocking HMG-CoA reductase, an enzyme needed for cholesterol production in the liver. This reduces LDL ("bad" cholesterol), increases HDL ("good" cholesterol), and helps prevent cholesterol buildup in blood vessels, lowering the risk of heart attacks and strokes.
Is Fluvastatin effective?
Yes, fluvastatin is proven effective in lowering LDL cholesterol by 20-40%, increasing HDL cholesterol, and reducing the risk of heart disease. Clinical trials have shown a significant reduction in heart attacks and strokes in patients using statins like fluvastatin.
What is Fluvastatin?
Fluvastatin is a statin medication used to lower cholesterol levels and reduce the risk of heart disease. It works by inhibiting HMG-CoA reductase, an enzyme responsible for cholesterol production in the liver. By lowering LDL ("bad" cholesterol) and increasing HDL ("good" cholesterol), it helps prevent heart attacks and strokes.
Directions for Use
For how long do I take Fluvastatin?
Fluvastatin is usually taken long-term, sometimes for life, to maintain healthy cholesterol levels. Your doctor will monitor cholesterol levels regularly and adjust the dose if needed. Do not stop taking it without consulting your doctor, as cholesterol levels may rise again.
How do I take Fluvastatin?
Fluvastatin can be taken with or without food, but should be taken at the same time each day for best results. The extended-release tablet should be swallowed whole and not crushed. Avoid grapefruit juice, as it may affect drug metabolism.
How long does it take for Fluvastatin to start working?
Fluvastatin begins lowering cholesterol within a few days, but full effects are seen after 4 to 6 weeks of regular use. Your doctor may conduct blood tests during this period to check cholesterol levels and adjust the dosage if needed.
How should I store Fluvastatin?
Store fluvastatin at room temperature (20-25°C or 68-77°F), away from moisture, heat, and direct sunlight. Keep the bottle tightly closed and out of reach of children. Do not store it in the bathroom.
What is the usual dose of Fluvastatin?
The usual adult dose is 20 to 80 mg daily, either once at bedtime or divided into two doses. Children aged 10-16 years may take 20-40 mg once daily. The extended-release form is usually taken as 80 mg once daily. Doses may vary based on cholesterol levels and medical history.
Warnings and Precautions
Can Fluvastatin be taken safely while breastfeeding?
No, fluvastatin should not be used while breastfeeding, as it may pass into breast milk and affect the baby’s development. If cholesterol treatment is necessary, alternative medications may be recommended.
Can Fluvastatin be taken safely while pregnant?
No, fluvastatin should not be taken during pregnancy, as it can harm the developing baby. Cholesterol is essential for fetal growth, and statins may interfere with this process. Women of childbearing age should use effective contraception while taking this medicine.
Can I take Fluvastatin with other prescription drugs?
Fluvastatin can interact with blood thinners (warfarin), certain antibiotics (erythromycin, clarithromycin), antifungal drugs, and other cholesterol-lowering medications (gemfibrozil, niacin). These interactions may increase the risk of side effects, so always inform your doctor about all medicines you are taking.
Is Fluvastatin safe for the elderly?
Yes, fluvastatin is generally safe for older adults, but they may be at higher risk of muscle pain, liver problems, and kidney complications. Lower starting doses are often recommended, with regular monitoring of liver function and muscle health.
Is it safe to drink alcohol while taking Fluvastatin?
Drinking alcohol in moderation is generally safe, but excessive alcohol increases the risk of liver damage. Since fluvastatin is processed by the liver, it’s best to limit alcohol intake to reduce stress on the liver. If you drink regularly, discuss this with your doctor.
Is it safe to exercise while taking Fluvastatin?
Yes, regular exercise is highly recommended while taking fluvastatin, as it helps lower cholesterol and improves heart health. However, if you experience severe muscle pain, stop exercising and consult your doctor, as this may indicate a rare but serious muscle condition called rhabdomyolysis.
Who should avoid taking Fluvastatin?
People with active liver disease, pregnant or breastfeeding women, and those with a history of statin-induced muscle problems should avoid fluvastatin. It should also be used cautiously in people with kidney disease or alcohol dependence.
