Fezolinetant
Hot Flashes
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Neurokinin 3 Receptor Antagonist
Controlled Drug Substance
No
Fezolinetant
Summary
Fezolinetant is used to treat moderate to severe vasomotor symptoms, such as hot flashes and night sweats, that are associated with menopause.
Fezolinetant works by blocking a receptor in the brain called the neurokinin 3 receptor. This helps regulate the body's temperature control center, reducing symptoms like hot flashes.
The usual dose for adults is 45 mg of Fezolinetant taken once daily. The medication comes in a tablet form that should be swallowed whole with liquid, with or without food.
Common side effects of Fezolinetant include abdominal pain, diarrhea, insomnia, and back pain. In some cases, it can cause liver injury, which requires immediate medical attention.
Fezolinetant is not recommended during breastfeeding or pregnancy. It should not be used with certain medications, like CYP1A2 inhibitors, and is not suitable for individuals with cirrhosis or severe renal impairment. Regular liver function tests are required before and during treatment.
Indications and Purpose
How does Fezolinetant work?
Fezolinetant works by affecting certain processes in the body to provide relief or manage symptoms. If you have questions about how Fezolinetant works, discuss them with your healthcare provider. They can provide more detailed information based on your specific health needs.
Is Fezolinetant effective?
Fezolinetant is effective for its primary therapeutic use. Clinical studies support its effectiveness for the indicated conditions. If you have questions about how well Fezolinetant is working for you, discuss them with your healthcare provider.
What is Fezolinetant?
Fezolinetant is a medication used to treat specific health conditions. It works by affecting certain processes in the body to provide relief or manage symptoms. If you have questions about what Fezolinetant is used for, discuss them with your healthcare provider.
Directions for Use
For how long do I take Fezolinetant?
Fezolinetant is usually a long-term medication for managing ongoing health conditions. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Fezolinetant treatment.
How do I dispose of Fezolinetant?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Fezolinetant?
Fezolinetant is usually taken as a pill once daily. You can take it with or without food. If you miss a dose, take it when you remember unless it's almost time for your next dose. Then just skip the missed dose and continue your normal schedule. Never take two doses at once. Always follow your doctor's specific advice about how to take this medication.
How long does it take for Fezolinetant to start working?
Fezolinetant begins working in your body shortly after you take it. However, you may not notice all the benefits right away. How quickly the medication works can depend on your overall health. Take it exactly as prescribed for the best results.
How should I store Fezolinetant?
Keep Fezolinetant tablets at room temperature, away from moisture and light. Store the medication in a tightly closed container. Don't keep your medicine in humid places like bathrooms. Always store Fezolinetant out of children's reach to prevent accidental swallowing.
What is the usual dose of Fezolinetant?
The usual starting dose of Fezolinetant for adults is typically determined by your doctor based on your specific health needs. It's important to follow your doctor's dosing instructions carefully. If you have any questions about your dose or need adjustments, consult your healthcare provider.
Warnings and Precautions
Can Fezolinetant be taken safely while breastfeeding?
Fezolinetant is not recommended while breastfeeding. If you're taking Fezolinetant and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Fezolinetant be taken safely while pregnant?
Fezolinetant isn't recommended during pregnancy. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your health during this important time. Your doctor can help create a pregnancy-specific treatment plan that protects both you and your baby.
Can I take Fezolinetant with other prescription drugs?
Fezolinetant may have major and moderate drug interactions. Always tell your doctor about all medicines you take to avoid interactions that could increase the risk of adverse effects or reduce the effectiveness of Fezolinetant. Your doctor can help manage any potential interactions.
Does Fezolinetant have adverse effects?
Adverse effects are unwanted reactions that can happen when taking a medication. Fezolinetant can cause unwanted reactions, though most people tolerate it well. If you experience any new or worsening symptoms while taking Fezolinetant, always tell your doctor. They can help determine if your symptoms are related to the medication and recommend appropriate action.
Does Fezolinetant have any safety warnings?
Fezolinetant has important safety warnings you should know about. Always follow your doctor's instructions and the prescription information. If you experience any unusual symptoms or side effects, contact your healthcare provider immediately. Not adhering to safety warnings can lead to serious health consequences.
Is Fezolinetant addictive?
Fezolinetant is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, you can feel confident that Fezolinetant doesn't carry this risk while managing your health condition.
Is Fezolinetant safe for the elderly?
The elderly are more vulnerable to safety risks of medicine due to age-related changes in the body. Fezolinetant is generally safe for the elderly, but specific risks or negative outcomes may be more frequently observed. Always consult your doctor about any concerns or conditions that might affect your use of Fezolinetant.
Is it safe to drink alcohol while taking Fezolinetant?
It's best to avoid alcohol while taking Fezolinetant. Alcohol can cause dehydration, which may worsen side effects of Fezolinetant. Talk with your doctor about alcohol use while taking Fezolinetant to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Fezolinetant?
You can exercise while taking Fezolinetant, but keep a few things in mind. This medication can cause dehydration, which might make you feel dizzy during exercise. To exercise safely, drink plenty of water before, during, and after physical activity. If you notice symptoms like dizziness, slow down or stop exercising and rest.
Is it safe to stop Fezolinetant?
Stopping Fezolinetant suddenly can cause problems for your health conditions. Always talk with your doctor before stopping Fezolinetant. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Fezolinetant?
Side effects are unwanted reactions that can happen when taking a medication. With Fezolinetant, these effects vary from person to person. If you notice new symptoms after starting Fezolinetant, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Fezolinetant?
Don't take Fezolinetant if you're allergic to it or its ingredients. Always consult your doctor about any concerns or conditions that might affect your use of Fezolinetant. They can help determine if this medication is safe for you.
