Fesoterodine
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Fesoterodine
Summary
Fesoterodine is used to treat symptoms of overactive bladder such as frequent urination, urgency, and incontinence.
Fesoterodine is an antimuscarinic medication. It works by blocking certain receptors in the bladder, which helps relax the bladder muscles and control urination.
The usual starting dose for adults with overactive bladder is 4 mg once daily. This can be increased to a maximum of 8 mg daily based on individual response and tolerability. The tablets should be swallowed whole with plenty of liquid.
Common side effects of Fesoterodine include dry mouth, constipation, headache, and insomnia. It can also cause drowsiness and blurred vision.
Fesoterodine should not be used by people with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, or known hypersensitivity to the drug. It should be used with caution in patients with bladder outlet obstruction or decreased gastrointestinal motility. It is not recommended for use during pregnancy or breastfeeding, and it can interact with certain other medications.
Indications and Purpose
How does Fesoterodine work?
Fesoterodine is an antimuscarinic agent that works by blocking muscarinic receptors in the bladder. This action relaxes the bladder muscles, reducing the frequency and urgency of urination and helping to control incontinence.
Is Fesoterodine effective?
Fesoterodine has been shown to be effective in treating overactive bladder symptoms, including urge urinary incontinence, urgency, and frequency. Clinical trials demonstrated significant reductions in the number of micturitions and urge incontinence episodes per 24 hours compared to placebo, with improvements observed as early as two weeks after starting treatment.
What is Fesoterodine?
Fesoterodine is used to treat overactive bladder symptoms such as frequent urination, urgency, and incontinence. It works by relaxing the bladder muscles, which helps to prevent urgent, frequent, or uncontrolled urination. Fesoterodine is an antimuscarinic medication that blocks certain receptors in the bladder.
Directions for Use
For how long do I take Fesoterodine?
Fesoterodine is typically used long-term to manage symptoms of overactive bladder. The full benefit may take up to 12 weeks to be felt, and it should be continued as prescribed by a healthcare provider to maintain symptom control.
How do I take Fesoterodine?
Fesoterodine should be taken once daily, with or without food, at the same time each day. Swallow the tablets whole with plenty of liquid; do not split, chew, or crush them. Discuss with your doctor about consuming grapefruit or grapefruit juice while on this medication.
How long does it take for Fesoterodine to start working?
Symptoms should begin to improve during the first few weeks of treatment with Fesoterodine, but it may take up to 12 weeks to feel the full benefit. Consistent daily use as prescribed is important for optimal results.
How should I store Fesoterodine?
Store Fesoterodine in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program, not by flushing it down the toilet.
What is the usual dose of Fesoterodine?
The usual starting dose for adults with overactive bladder is 4 mg once daily, which can be increased to a maximum of 8 mg daily based on individual response and tolerability. The safety and effectiveness of Fesoterodine in children under 6 years of age or weighing 25 kg or less have not been established.
Warnings and Precautions
Can Fesoterodine be taken safely while breastfeeding?
It is unknown whether Fesoterodine or its metabolites are excreted in human milk. Therefore, breastfeeding is not recommended during treatment with Fesoterodine. Discuss with your healthcare provider to weigh the benefits and risks of continuing the medication while breastfeeding.
Can Fesoterodine be taken safely while pregnant?
There are no adequate data on the use of Fesoterodine in pregnant women. Animal studies have shown some fetotoxicity at high doses. The potential risk to humans is unknown, so Fesoterodine is not recommended during pregnancy unless the benefits outweigh the risks. Consult a healthcare provider for personalized advice.
Can I take Fesoterodine with other prescription drugs?
Fesoterodine interacts with strong CYP3A4 inhibitors like ketoconazole, which can increase its concentration in the body. It should not be used with other antimuscarinic drugs as this may increase side effects. Caution is advised when used with medications that affect gastrointestinal motility.
Is Fesoterodine safe for the elderly?
Elderly patients may experience a higher incidence of antimuscarinic side effects such as dry mouth, constipation, and urinary tract infections. No dose adjustment is recommended solely based on age, but caution is advised, especially in those over 75 years old. Regular monitoring and consultation with a healthcare provider are recommended.
Is it safe to drink alcohol while taking Fesoterodine?
Drinking alcohol while taking Fesoterodine may enhance the drowsiness caused by the medication. It is advisable to be cautious with alcohol consumption to avoid increased drowsiness and potential impairment.
Is it safe to exercise while taking Fesoterodine?
Fesoterodine may cause drowsiness and blurred vision, which could affect your ability to exercise safely. It is important to understand how the medication affects you before engaging in physical activities. Consult your healthcare provider if you have concerns about exercising while on this medication.
Who should avoid taking Fesoterodine?
Fesoterodine is contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and known hypersensitivity to the drug. It should be used with caution in patients with bladder outlet obstruction, decreased gastrointestinal motility, and those taking strong CYP3A4 inhibitors. Patients should be aware of potential side effects like drowsiness and blurred vision.
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