Fenoprofen
Rheumatoid Arthritis, Pain ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Controlled Drug Substance
No
Fenoprofen
Summary
Fenoprofen is used to treat mild to moderate pain, and the signs and symptoms of conditions like rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gouty arthritis. It can also be used to reduce fever.
Fenoprofen works by inhibiting enzymes called COX-1 and COX-2, which are involved in the production of chemicals called prostaglandins. These chemicals promote inflammation, pain, and fever. By reducing their production, Fenoprofen helps alleviate these symptoms.
For mild to moderate pain, the usual dose is 200 mg every 4 to 6 hours as needed. For conditions like rheumatoid arthritis or osteoarthritis, the recommended dose is 400 to 600 mg taken orally 3 or 4 times a day. The total daily dosage should not exceed 3200 mg. It is not recommended for children under 18 years of age.
Common side effects include gastrointestinal issues like nausea and constipation, and headaches. Serious adverse effects can include cardiovascular events, gastrointestinal bleeding, and renal impairment.
Fenoprofen carries a risk of serious cardiovascular events like heart attack and stroke, and gastrointestinal issues including bleeding and ulcers. It's not recommended for patients with known hypersensitivity to NSAIDs, those who have had coronary artery bypass graft surgery, and those with severe renal impairment.
Indications and Purpose
How does Fenoprofen work?
Fenoprofen works by inhibiting the enzymes COX-1 and COX-2, which are involved in the production of prostaglandins. Prostaglandins are chemicals in the body that promote inflammation, pain, and fever. By reducing their production, Fenoprofen helps alleviate these symptoms.
Is Fenoprofen effective?
Fenoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that effectively reduces pain, inflammation, and fever by inhibiting the production of prostaglandins. Clinical studies have shown it to be effective in relieving symptoms of rheumatoid arthritis, osteoarthritis, and mild to moderate pain.
What is Fenoprofen?
Fenoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness from conditions like osteoarthritis and rheumatoid arthritis. It works by inhibiting the production of prostaglandins, substances in the body that cause inflammation and pain. Fenoprofen is also used for mild to moderate pain relief from other causes.
Directions for Use
For how long do I take Fenoprofen?
Fenoprofen is typically used for short-term relief of pain. For arthritis, it may be used for longer periods, but the duration should be as short as possible to minimize risks. Always follow your doctor's instructions regarding the duration of use.
How do I take Fenoprofen?
Fenoprofen should be taken with a full glass of water and can be taken with food or milk to reduce stomach upset. Your doctor may also recommend taking it with an antacid. There are no specific food restrictions, but avoid alcohol to reduce the risk of stomach bleeding.
How long does it take for Fenoprofen to start working?
Fenoprofen typically begins to relieve pain within a few hours of taking a dose. For arthritis symptoms, it may take a few days to notice improvement, and up to 2-3 weeks to feel the full benefit. Always follow your doctor's instructions for use.
How should I store Fenoprofen?
Store Fenoprofen in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and pets. Do not store it in the bathroom, and dispose of any unneeded medication through a take-back program.
What is the usual dose of Fenoprofen?
For adults, the usual dose of Fenoprofen for mild to moderate pain is 200 mg every 4 to 6 hours as needed. For rheumatoid arthritis or osteoarthritis, the recommended dose is 400 to 600 mg taken orally 3 or 4 times a day. The total daily dosage should not exceed 3,200 mg. Fenoprofen is not recommended for use in children under 18 years of age as safety and effectiveness have not been established.
Warnings and Precautions
Can Fenoprofen be taken safely while breastfeeding?
Fenoprofen is excreted in breast milk in small amounts. While the risk to the infant is considered low, it is important to weigh the benefits against potential risks. Consult your doctor before using Fenoprofen while breastfeeding to ensure it is safe for you and your baby.
Can Fenoprofen be taken safely while pregnant?
Fenoprofen is not recommended during pregnancy, especially after 20 weeks, due to the risk of fetal harm, including premature closure of the ductus arteriosus and renal issues. If necessary, it should only be used under strict medical supervision. Consult your doctor for personalized advice.
Can I take Fenoprofen with other prescription drugs?
Fenoprofen can interact with anticoagulants like warfarin, increasing the risk of bleeding. It may also reduce the effectiveness of antihypertensive drugs like ACE inhibitors and diuretics. Combining Fenoprofen with other NSAIDs or aspirin can increase the risk of gastrointestinal issues. Always inform your doctor of all medications you are taking.
Is Fenoprofen safe for the elderly?
Elderly patients are at a higher risk for serious cardiovascular, gastrointestinal, and renal side effects when taking Fenoprofen. It is recommended to start with the lowest effective dose and monitor for adverse effects. Regular check-ups with a healthcare provider are advised to ensure safe use.
Is it safe to drink alcohol while taking Fenoprofen?
Drinking alcohol while taking Fenoprofen can increase the risk of stomach bleeding. Alcohol can also enhance the drowsiness effect of Fenoprofen, making it unsafe to drive or operate machinery. It is advisable to avoid alcohol consumption while taking this medication to minimize these risks.
Is it safe to exercise while taking Fenoprofen?
Fenoprofen may cause drowsiness or dizziness, which could affect your ability to exercise safely. If you experience these side effects, it is advisable to avoid strenuous activities until you know how the medication affects you. Consult your doctor if you have concerns about exercising while taking Fenoprofen.
Who should avoid taking Fenoprofen?
Fenoprofen carries a risk of serious cardiovascular events, such as heart attack and stroke, and gastrointestinal issues, including bleeding and ulcers. It is contraindicated in patients with known hypersensitivity to NSAIDs, those who have had coronary artery bypass graft surgery, and those with severe renal impairment. Patients should be monitored for signs of adverse effects.
