Fedratinib
Primary Myelofibrosis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Fedratinib
Summary
Fedratinib is used to treat adults with certain types of myelofibrosis, a cancer of the bone marrow. It's specifically indicated for intermediate-2 or high-risk primary or secondary myelofibrosis, including post-polycythemia vera or post-essential thrombocythemia myelofibrosis.
Fedratinib is a kinase inhibitor. It targets and blocks the action of abnormal proteins, specifically Janus Associated Kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3), which are involved in the growth and spread of cancer cells. By inhibiting these proteins, it helps slow down or stop the proliferation of cancer cells.
The usual daily dose of Fedratinib for adults is 400 mg taken orally once daily. It can be taken with or without food.
Common side effects of Fedratinib include diarrhea, nausea, vomiting, anemia, and weight gain. Serious adverse effects include encephalopathy, thrombocytopenia, and liver enzyme elevations.
Fedratinib can cause serious and potentially fatal encephalopathy, including Wernicke's encephalopathy. It's contraindicated during pregnancy and breastfeeding. Women of childbearing potential should use effective contraception during treatment and for at least 1 month after the last dose. Patients should not start treatment if they have a thiamine deficiency.
Indications and Purpose
How does Fedratinib work?
Fedratinib works by inhibiting certain proteins called kinases, which are involved in the growth and survival of cancer cells. By blocking these proteins, Fedratinib helps reduce the size of the spleen and improve symptoms in patients with myelofibrosis, which is a type of bone marrow cancer. This action helps manage the disease and improve quality of life.
Is Fedratinib effective?
Fedratinib is effective for treating myelofibrosis, which is a type of bone marrow cancer. Clinical studies show it can reduce spleen size and improve symptoms in patients. This medication works by inhibiting certain proteins that contribute to the disease. If you have questions about its effectiveness for your condition, discuss them with your doctor.
What is Fedratinib?
Fedratinib is a medication used to treat myelofibrosis, which is a type of bone marrow cancer. It belongs to a class of drugs called kinase inhibitors, which work by blocking certain proteins that contribute to the disease. This helps reduce symptoms and improve quality of life. Fedratinib is usually used when other treatments haven't worked or aren't suitable.
Directions for Use
For how long do I take Fedratinib?
Fedratinib is usually a long-term medication for managing myelofibrosis, which is a type of bone marrow cancer. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Fedratinib treatment.
How do I dispose of Fedratinib?
Dispose of unused Fedratinib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. This helps prevent harm to people and the environment.
How do I take Fedratinib?
Take Fedratinib as prescribed by your doctor. It's usually taken once daily. You can take it with or without food, but it's best to follow your doctor's specific instructions. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's advice about diet and fluid intake while on this medication.
How long does it take for Fedratinib to start working?
Fedratinib begins working in your body shortly after you take it, but you may not notice all the benefits right away. Some improvements in symptoms like fatigue and abdominal discomfort might be seen within weeks, but more significant changes can take several months. How quickly the medication works can depend on your overall health and response to treatment. Take it exactly as prescribed for the best results.
How should I store Fedratinib?
Store Fedratinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Avoid storing it in humid places like bathrooms. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Fedratinib out of children's reach to prevent accidental swallowing.
What is the usual dose of Fedratinib?
The usual starting dose of Fedratinib for adults is 400 mg once daily. Your doctor may adjust your dose based on your response and any side effects. The maximum recommended dose is 600 mg daily. Always follow your doctor's specific dosing instructions for your health needs. If you have any concerns about your dose, discuss them with your healthcare provider.
Warnings and Precautions
Can Fedratinib be taken safely while breastfeeding?
Fedratinib is not recommended while breastfeeding. There's limited information on whether it passes into human breast milk. Animal studies suggest it might, raising concerns about potential risks to a baby's developing organs. If you're taking Fedratinib and want to breastfeed, discuss safer medication options with your doctor to ensure your baby's safety.
Can Fedratinib be taken safely while pregnant?
Fedratinib is not recommended during pregnancy due to limited evidence on its safety. Animal studies suggest potential risks, but human data is lacking. Uncontrolled myelofibrosis during pregnancy can cause serious problems for both mother and baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Can I take Fedratinib with other prescription drugs?
Fedratinib can interact with other medications, increasing the risk of side effects or reducing effectiveness. It's important to inform your doctor about all the medicines you're taking, including over-the-counter drugs and supplements. Your doctor can help manage potential interactions and adjust your treatment plan as needed to ensure safety and effectiveness.
Does Fedratinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Fedratinib include nausea, vomiting, and diarrhea. These occur in more than 10% of patients. Serious side effects can include anemia and liver problems. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these are related to Fedratinib and suggest appropriate actions.
Does Fedratinib have any safety warnings?
Yes, Fedratinib has important safety warnings. It can cause serious side effects like anemia, which is a low red blood cell count, and liver problems. Regular blood tests are needed to monitor your health. If you experience symptoms like unusual tiredness, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Not adhering to these warnings can lead to severe health issues.
Is Fedratinib addictive?
Fedratinib is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Fedratinib works by targeting specific proteins in the body to treat certain conditions, and this mechanism doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, discuss them with your doctor.
Is Fedratinib safe for the elderly?
Elderly patients are more vulnerable to the side effects of Fedratinib, such as anemia and liver problems. They may require closer monitoring and dose adjustments. Regular check-ups and blood tests are important to ensure safety. If you're elderly and taking Fedratinib, discuss any concerns with your doctor to manage your treatment effectively.
Is it safe to drink alcohol while taking Fedratinib?
It's best to avoid alcohol while taking Fedratinib. Alcohol can increase the risk of liver problems, which are a potential side effect of this medication. Drinking alcohol may also worsen side effects like dizziness or nausea. If you choose to drink, limit your intake and watch for warning signs like unusual tiredness or yellowing of the skin. Talk with your doctor about alcohol use while on Fedratinib.
Is it safe to exercise while taking Fedratinib?
You can exercise while taking Fedratinib, but be cautious. This medication can cause fatigue and dizziness, which might affect your exercise capacity. If you feel dizzy or unusually tired during physical activity, slow down or stop and rest. Drink plenty of water to stay hydrated. Most people can maintain their regular exercise routine, but check with your doctor if you have concerns.
Is it safe to stop Fedratinib?
Stopping Fedratinib suddenly can cause your condition to worsen. It's usually used for long-term treatment of chronic conditions. If you need to stop taking it, your doctor might suggest gradually reducing your dose or switching to a different medication. Always talk with your doctor before stopping Fedratinib to ensure any changes are made safely.
What are the most common side effects of Fedratinib?
Side effects are unwanted reactions to a medication. Common side effects of Fedratinib include nausea, vomiting, and diarrhea, affecting more than 10% of people. If you experience these, they might be temporary or unrelated to the medication. Talk with your doctor if you have concerns. They can help determine if the side effects are related to Fedratinib and suggest ways to manage them.
Who should avoid taking Fedratinib?
Don't take Fedratinib if you're allergic to it or its ingredients. It's contraindicated in patients with severe liver problems. Caution is needed for those with a history of anemia or gastrointestinal bleeding. Always consult your doctor about your medical history before starting Fedratinib to ensure it's safe for you.
