Ezetimibe
Familial Combined Hyperlipidemia, Hypercholesterolemia ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Dietary Cholesterol Absorption Inhibitor
Controlled Drug Substance
No
Ezetimibe
Summary
Ezetimibe is primarily used to treat high cholesterol, also known as hypercholesterolemia. It can lower bad cholesterol (LDL) and total cholesterol levels. It's also used to treat a condition called homozygous familial hypercholesterolemia and to reduce cholesterol in patients with atherosclerosis, which can help reduce the risk of heart attack, stroke, and other cardiovascular conditions.
Ezetimibe works by blocking the absorption of cholesterol in your small intestine. It specifically targets a protein responsible for transporting cholesterol into your bloodstream. By blocking this protein, Ezetimibe reduces the amount of cholesterol that enters your body, which can lower your total and LDL cholesterol levels.
The usual dosage of Ezetimibe for adults is 10 mg once daily. It can be taken with or without food and at any time of the day. If you're taking it with a statin, both medications can typically be taken together. Always follow your healthcare provider's instructions.
Common side effects of Ezetimibe include headache, diarrhea, abdominal pain, and muscle pain. More serious adverse effects are rare but may include liver problems and allergic reactions, such as rash or swelling. In some cases, Ezetimibe can cause muscle weakness or inflammation, and very rarely severe muscle breakdown.
Ezetimibe should be used with caution in patients with liver disease, as it may increase the risk of liver problems. It is not recommended for patients with a known hypersensitivity to Ezetimibe or any of its components. Patients who are pregnant or breastfeeding should avoid using Ezetimibe unless specifically advised by a healthcare provider, as its safety during these times is not well established.
Indications and Purpose
How does Ezetimibe work?
Ezetimibe works by reducing the amount of cholesterol absorbed in the intestines. Think of it like a sponge that soaks up less cholesterol from the food you eat. This helps lower the levels of LDL cholesterol, which is often called "bad" cholesterol, in your blood. Lowering cholesterol levels helps reduce the risk of heart disease.
Is Ezetimibe effective?
Ezetimibe is effective in lowering cholesterol levels, particularly LDL cholesterol, which is often called "bad" cholesterol. It works by reducing the amount of cholesterol absorbed in the intestines. Clinical studies show that Ezetimibe can significantly lower LDL cholesterol levels, which helps reduce the risk of heart disease.
What is Ezetimibe?
Ezetimibe is a medication used to lower cholesterol levels. It belongs to a class of drugs called cholesterol absorption inhibitors. Ezetimibe works by reducing the amount of cholesterol absorbed in the intestines. It's primarily used to treat high cholesterol and is often used alongside other cholesterol-lowering medications like statins.
Directions for Use
For how long do I take Ezetimibe?
Ezetimibe is usually a long-term medication for managing cholesterol levels. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Ezetimibe treatment.
How do I dispose of Ezetimibe?
If you can, bring unused Ezetimibe to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Ezetimibe?
Ezetimibe is usually taken once daily, with or without food. It's important to take it at the same time each day. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions regarding your medication.
How long does it take for Ezetimibe to start working?
Ezetimibe begins working in your body shortly after you take it, but it may take a few weeks to see significant changes in your cholesterol levels. The full therapeutic effect is usually observed after about two weeks. Individual factors like diet, exercise, and overall health can affect how quickly you notice results. Take it exactly as prescribed for the best results.
How should I store Ezetimibe?
Store Ezetimibe at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep Ezetimibe out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Ezetimibe?
The usual dose of Ezetimibe for adults is 10 mg once daily, with or without food. This dose is typically not adjusted for different populations, but always follow your doctor's specific dosing instructions. If you have any concerns about your dose, discuss them with your healthcare provider.
Warnings and Precautions
Can Ezetimibe be taken safely while breastfeeding?
Ezetimibe is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. If you're taking Ezetimibe and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Ezetimibe be taken safely while pregnant?
Ezetimibe is not recommended during pregnancy due to limited information on its safety. Uncontrolled cholesterol levels during pregnancy can cause problems for both mother and baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your cholesterol during this important time.
Can I take Ezetimibe with other prescription drugs?
Ezetimibe can interact with certain medications, such as cyclosporine, which is used to prevent organ rejection, and some cholesterol-lowering drugs like fibrates. These interactions can increase the risk of side effects or reduce the effectiveness of Ezetimibe. Always inform your doctor about all the medications you are taking to avoid potential interactions.
Does Ezetimibe have adverse effects?
Adverse effects are unwanted reactions to a medication. Ezetimibe is generally well-tolerated, but some people may experience side effects like diarrhea, joint pain, or tiredness. Serious side effects are rare but can include liver problems. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Ezetimibe.
Does Ezetimibe have any safety warnings?
Ezetimibe has safety warnings you should be aware of. It can cause liver problems, so your doctor may monitor your liver function. If you experience symptoms like yellowing of the skin or eyes, dark urine, or severe stomach pain, contact your doctor immediately. Always follow your doctor's advice and report any unusual symptoms.
Is Ezetimibe addictive?
Ezetimibe is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Ezetimibe doesn't carry this risk.
Is Ezetimibe safe for the elderly?
Ezetimibe is generally safe for elderly patients, with no significant differences in safety or effectiveness compared to younger adults. However, elderly patients should be monitored closely for any side effects, and dosage adjustments may be necessary based on individual health conditions.
Is it safe to drink alcohol while taking Ezetimibe?
It's best to limit alcohol while taking Ezetimibe. Alcohol can affect your liver, and Ezetimibe can also impact liver function. Drinking alcohol may increase the risk of liver problems. Talk with your doctor about alcohol use while taking Ezetimibe to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Ezetimibe?
You can exercise while taking Ezetimibe. This medication doesn't typically limit exercise capacity. Regular physical activity is beneficial for heart health and can complement the effects of Ezetimibe. If you have concerns about your specific situation, talk with your doctor for personalized advice.
Is it safe to stop Ezetimibe?
Ezetimibe is often used long-term for managing cholesterol levels. Stopping it suddenly may cause your cholesterol to rise, increasing the risk of heart disease. Always talk with your doctor before stopping Ezetimibe. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
What are the most common side effects of Ezetimibe?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Ezetimibe include diarrhea, joint pain, and tiredness. These effects vary from person to person. If you notice new symptoms after starting Ezetimibe, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Ezetimibe?
Don't take Ezetimibe if you're allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Ezetimibe should be used with caution in people with liver problems. Always consult your doctor about these concerns.
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