Etrasimod
Ulcerative Colitis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Etrasimod
Summary
Etrasimod is used to treat moderately to severely active ulcerative colitis in adults. Ulcerative colitis is a condition that involves inflammation and sores in the lining of the colon and rectum.
Etrasimod works by modulating the sphingosine 1-phosphate receptors. This reduces the number of lymphocytes, a type of white blood cell, in the blood, thereby decreasing inflammation in the colon. This helps manage symptoms like swelling and sores in the colon lining.
The usual daily dose of Etrasimod for adults is 2 mg taken orally once a day. It can be taken with or without food and it is important to take it at the same time each day for consistency.
Common side effects of Etrasimod include headache, dizziness, and elevated liver tests. Some serious adverse effects can include infections, slow heart rate, liver injury, and macular edema, a condition that affects vision.
Etrasimod should not be used by pregnant women due to potential harm to the unborn baby. It is also not recommended for patients with recent heart attack, stroke, or certain heart rhythm disorders. Patients should be monitored for infections and liver function, and avoid live vaccines during treatment.
Indications and Purpose
How does Etrasimod work?
Etrasimod works by modulating sphingosine 1-phosphate receptors, which are involved in the movement of lymphocytes. By reducing the number of lymphocytes in the blood, it decreases inflammation in the colon, helping to manage symptoms of ulcerative colitis.
Is Etrasimod effective?
Etrasimod has been evaluated in clinical studies for its effectiveness in treating moderately to severely active ulcerative colitis. In these studies, a greater proportion of patients treated with Etrasimod achieved clinical remission, endoscopic improvement, and symptomatic remission compared to those receiving a placebo. These results support its effectiveness in managing ulcerative colitis symptoms.
What is Etrasimod?
Etrasimod is used to treat moderately to severely active ulcerative colitis in adults. It works by modulating the sphingosine 1-phosphate receptors, which reduces the number of lymphocytes in the blood, thereby decreasing inflammation in the colon. This helps manage symptoms like swelling and sores in the colon lining.
Directions for Use
For how long do I take Etrasimod?
Etrasimod is used for the treatment of moderately to severely active ulcerative colitis and is typically taken as long-term therapy to manage symptoms. The exact duration of use should be determined by a healthcare provider based on individual patient needs and response to treatment.
How do I take Etrasimod?
Etrasimod should be taken orally once a day, with or without food. It is important to take it at the same time each day for consistency. There are no specific food restrictions while taking Etrasimod, but always follow your healthcare provider's advice regarding diet and medication use.
How long does it take for Etrasimod to start working?
Etrasimod may start to show effects within a few weeks, but the full benefit might take longer to be noticeable. The exact time can vary depending on individual response to the medication. Regular follow-ups with your healthcare provider will help assess its effectiveness.
How should I store Etrasimod?
Etrasimod should be stored at room temperature, between 68°F to 77°F (20°C to 25°C). It should be kept in its original container, tightly closed, and away from excess heat and moisture. Ensure it is out of reach of children to prevent accidental ingestion.
What is the usual dose of Etrasimod?
The usual daily dose of Etrasimod for adults is 2 mg taken orally once a day. The safety and effectiveness of Etrasimod in children have not been established, so there is no recommended dose for children.
Warnings and Precautions
Can Etrasimod be taken safely while breastfeeding?
It is not known if Etrasimod passes into breast milk, so breastfeeding while taking this medication is not recommended. Discuss with your healthcare provider the best way to feed your baby if you are taking Etrasimod, to ensure the safety of your child.
Can Etrasimod be taken safely while pregnant?
Etrasimod is not recommended during pregnancy due to potential harm to the unborn baby. Animal studies have shown fetal harm, and women of childbearing potential should use effective contraception during treatment and for at least 7 days after stopping Etrasimod. If pregnancy occurs, contact your healthcare provider immediately.
Can I take Etrasimod with other prescription drugs?
Etrasimod may interact with medications that affect heart rate, such as beta-blockers and calcium channel blockers, and with drugs that suppress the immune system. It is also affected by moderate to strong inhibitors or inducers of CYP2C9 and CYP3A4 enzymes. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Is Etrasimod safe for the elderly?
Etrasimod should be used with caution in elderly patients, especially those over 65 years of age, due to the potential for increased risk of adverse reactions. It is important for elderly patients to have regular monitoring and to discuss any concerns with their healthcare provider to ensure safe use of the medication.
Is it safe to exercise while taking Etrasimod?
Etrasimod may cause dizziness or a slow heart rate, which could affect your ability to exercise safely. If you experience these symptoms, it is important to talk to your healthcare provider before engaging in physical activities. They can provide guidance on safe exercise practices while taking this medication.
Who should avoid taking Etrasimod?
Important warnings for Etrasimod include the risk of infections, slow heart rate, liver injury, and macular edema. It is contraindicated in patients with recent heart attack, stroke, or certain heart rhythm disorders. Patients should be monitored for infections and liver function, and avoid live vaccines during treatment. Pregnant women should not use Etrasimod due to potential fetal harm.
