Ethacrynate
Hypertension, Chronic Kidney Failure ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Loop Diuretic
Controlled Drug Substance
No
Ethacrynate
Summary
Ethacrynic acid is used to treat fluid retention or edema associated with conditions such as heart failure, liver cirrhosis, kidney disease, and nephrotic syndrome. It is also used for short-term management of ascites due to malignancy, idiopathic edema, and lymphedema.
Ethacrynic acid works by increasing urine output and reducing fluid retention. It acts on the kidneys, specifically the ascending limb of the loop of Henle and the proximal and distal tubules, to increase urine output. It inhibits the reabsorption of sodium and chloride, leading to increased excretion of water and electrolytes.
Ethacrynic acid is usually taken by mouth once or twice a day with food or after meals. The usual starting dose for adults is 50 to 100 mg per day. For children, the initial dose is typically 25 mg. Always follow your doctor's specific dosage instructions.
Common side effects include frequent urination, nausea, vomiting, loss of appetite, stomach pain, and diarrhea. Serious side effects may include severe diarrhea, hearing loss, confusion, and unusual bleeding.
Ethacrynic acid should not be used in patients with anuria or severe electrolyte imbalance. It may cause severe diarrhea, hearing loss, or electrolyte depletion. Use caution in patients with liver disease as it may precipitate hepatic coma.
Indications and Purpose
How does Ethacrynate work?
Ethacrynic acid acts on the kidneys, specifically the ascending limb of the loop of Henle and the proximal and distal tubules, to increase urine output. It inhibits the reabsorption of sodium and chloride, leading to increased excretion of water and electrolytes, which helps reduce fluid retention and swelling.
Is Ethacrynate effective?
Ethacrynic acid is a potent diuretic that effectively treats edema associated with conditions like heart failure, liver cirrhosis, and renal disease. It works by increasing urine output and reducing fluid retention. Clinical studies and patient experiences support its effectiveness, especially in cases where other diuretics are insufficient.
What is Ethacrynate?
Ethacrynic acid is a diuretic used to treat fluid retention (edema) associated with conditions like heart failure, liver cirrhosis, and kidney disease. It works by helping the kidneys remove excess water and salt from the body, reducing swelling and fluid buildup. This medication is effective in patients who do not respond to other diuretics.
Directions for Use
For how long do I take Ethacrynate?
The duration of use for ethacrynic acid depends on the individual's medical condition and response to treatment. It is often used until the desired diuretic effect is achieved, and the dosage may be adjusted or discontinued based on the patient's needs. Always follow your doctor's guidance on the duration of use.
How do I take Ethacrynate?
Ethacrynic acid should be taken by mouth, usually once or twice a day with food or after meals, as directed by your doctor. Follow your doctor's dietary instructions, which may include a low-salt diet and increased potassium-rich foods. Always take the medication at the same time each day for best results.
How long does it take for Ethacrynate to start working?
Ethacrynic acid typically starts working within 30 minutes after an oral dose, with diuresis peaking in about 2 hours and lasting for 6 to 8 hours. If you have any concerns about how the medication is working, consult your doctor for personalized advice.
How should I store Ethacrynate?
Store ethacrynic acid in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and pets. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program to prevent accidental ingestion.
What is the usual dose of Ethacrynate?
For adults, the usual starting dose of ethacrynic acid is 50 to 100 mg per day, with maintenance doses ranging from 50 to 200 mg daily. For children, the initial dose is typically 25 mg, with careful increments of 25 mg to achieve effective maintenance. Always follow your doctor's specific dosage instructions.
Warnings and Precautions
Can Ethacrynate be taken safely while breastfeeding?
It is not known whether ethacrynic acid is excreted in human milk. Due to the potential for serious adverse reactions in nursing infants, a decision should be made to either discontinue nursing or discontinue the drug, considering the importance of the medication to the mother. Consult your doctor for personalized advice.
Can Ethacrynate be taken safely while pregnant?
Ethacrynic acid should be used during pregnancy only if clearly needed, as there are no adequate and well-controlled studies in pregnant women. Animal studies have not shown fetal harm, but human response may differ. Always consult your doctor for personalized advice if you are pregnant or planning to become pregnant.
Can I take Ethacrynate with other prescription drugs?
Ethacrynic acid may interact with nonsteroidal anti-inflammatory drugs (NSAIDs), lithium, and other diuretics, potentially increasing the risk of side effects. It may also enhance the ototoxic potential of certain antibiotics. Always inform your doctor of all medications you are taking to avoid harmful interactions.
Is Ethacrynate safe for the elderly?
Older adults should use ethacrynic acid with caution, as it may not be as safe as other medications for treating similar conditions. The elderly are more likely to experience side effects, so doctors may recommend alternative treatments. Always consult your doctor for personalized advice and follow their recommendations closely.
Is it safe to exercise while taking Ethacrynate?
Ethacrynic acid may cause weakness and muscle cramps, which could potentially affect your ability to exercise. If you experience these symptoms, consult your doctor. They may adjust your dosage or provide guidance on managing these effects while maintaining your exercise routine.
Who should avoid taking Ethacrynate?
Ethacrynic acid should not be used in patients with anuria or severe electrolyte imbalance. It may cause severe diarrhea, hearing loss, or electrolyte depletion. Use caution in patients with liver disease, as it may precipitate hepatic coma. Always consult your doctor for personalized advice and follow their recommendations closely.
