Estazolam
Sleep Initiation and Maintenance Disorders
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Benzodiazepine
Controlled Drug Substance
YES
Estazolam
Summary
Estazolam is used for short-term treatment of insomnia. It helps individuals who have difficulty falling asleep, experience frequent awakenings during the night, or wake up too early in the morning.
Estazolam works by enhancing the effects of a neurotransmitter called GABA in the brain. This slows down brain activity, inducing sleep and helping maintain sleep throughout the night.
The usual dose for adults is 1 mg at bedtime, but some may require 2 mg. Estazolam should be taken right before bedtime and can be taken with or without food.
Common side effects of Estazolam include drowsiness, dizziness, and headache. Serious adverse effects can include respiratory depression, severe allergic reactions, and withdrawal symptoms.
Estazolam should not be used during breastfeeding or pregnancy. It should not be used with opioids, ketoconazole, and itraconazole. Avoid alcohol and other CNS depressants while taking this medication as they can increase the risk of serious side effects.
Indications and Purpose
How does Estazolam work?
Estazolam works by enhancing the effects of a neurotransmitter called GABA in the brain, which slows down brain activity. This calming effect helps induce sleep and maintain sleep throughout the night.
Is Estazolam effective?
Clinical trials have shown that Estazolam is effective in improving sleep induction and maintenance in patients with insomnia. It has been found to reduce sleep latency and increase sleep duration, providing relief from insomnia symptoms.
What is Estazolam?
Estazolam is used for the short-term treatment of insomnia, helping people fall asleep and stay asleep. It belongs to a class of medications called benzodiazepines, which work by slowing brain activity to promote sleep. It is typically taken at bedtime.
Directions for Use
For how long do I take Estazolam?
Estazolam is typically prescribed for short-term use, generally not exceeding 12 weeks, to treat insomnia. Prolonged use is not recommended due to the risk of dependence and other side effects.
How do I take Estazolam?
Estazolam should be taken right before bedtime, and it can be taken with or without food. Avoid alcohol and other CNS depressants while taking this medication, as they can increase the risk of serious side effects.
How long does it take for Estazolam to start working?
Estazolam typically starts working within 30 minutes to 2 hours after taking it, helping to induce sleep. It's important to take it only when you are ready to go to bed and can stay asleep for a full night.
How should I store Estazolam?
Store Estazolam in a tightly closed, child-resistant container at room temperature, away from excess heat and moisture. Keep it out of reach of children to prevent accidental ingestion.
What is the usual dose of Estazolam?
The usual dose for adults is 1 mg at bedtime, but some may require 2 mg. Estazolam is not recommended for children as its safety and effectiveness have not been established in this age group.
Warnings and Precautions
Can Estazolam be taken safely while breastfeeding?
Breastfeeding is not recommended during treatment with Estazolam, as it may be excreted in breast milk and cause sedation or withdrawal symptoms in the infant. Consult a healthcare provider for advice on alternative treatments.
Can Estazolam be taken safely while pregnant?
Estazolam is not recommended during pregnancy due to potential risks to the fetus, including sedation and withdrawal symptoms in newborns. Pregnant women should consult their healthcare provider for safer alternatives.
Can I take Estazolam with other prescription drugs?
Estazolam interacts with opioids, increasing the risk of severe sedation and respiratory depression. It should not be used with ketoconazole and itraconazole. Caution is advised when used with other CNS depressants, anticonvulsants, and certain antibiotics that affect its metabolism.
Is Estazolam safe for the elderly?
Elderly patients should use Estazolam with caution due to increased sensitivity to its effects, such as drowsiness and dizziness, which can increase the risk of falls. A lower starting dose of 0.5 mg is recommended, and any dosage increases should be made carefully.
Is it safe to drink alcohol while taking Estazolam?
Drinking alcohol while taking Estazolam is not safe. Alcohol can increase the risk of serious side effects like severe drowsiness, breathing problems, and even coma. It is advised to avoid alcohol during treatment with Estazolam.
Is it safe to exercise while taking Estazolam?
Estazolam can cause drowsiness and dizziness, which may affect physical coordination and alertness, potentially limiting the ability to exercise safely. It's advisable to understand how the medication affects you before engaging in physical activities.
Who should avoid taking Estazolam?
Estazolam should not be used with opioids due to the risk of severe sedation and respiratory depression. It is contraindicated with ketoconazole and itraconazole. Caution is advised for those with a history of substance abuse, depression, or respiratory issues. Avoid alcohol and other CNS depressants.
