Ertugliflozin
NA
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Ertugliflozin
Summary
Ertugliflozin is used to manage blood sugar levels in adults with type 2 diabetes. It is used alongside diet and exercise to improve glycemic control. It is not recommended for type 1 diabetes or diabetic ketoacidosis.
Ertugliflozin works by inhibiting a protein in the kidneys called sodium-glucose cotransporter 2 (SGLT2). This prevents the reabsorption of glucose back into the bloodstream, leading to increased glucose excretion through urine. As a result, blood sugar levels are lowered.
The usual starting dose of Ertugliflozin for adults is 5 mg taken orally once daily. This can be increased to 15 mg if additional glycemic control is needed. It is not recommended for use in children under 18 years of age.
Common side effects of Ertugliflozin include increased urination, thirst, dry mouth, and headache. Serious adverse effects can include ketoacidosis, urinary tract infections, and lower limb amputation.
Ertugliflozin is contraindicated in patients with hypersensitivity to the drug, type 1 diabetes, or diabetic ketoacidosis. Important warnings include the risk of ketoacidosis, lower limb amputation, volume depletion, and serious urinary tract infections. Renal function should be assessed before starting treatment and periodically thereafter.
Indications and Purpose
How does Ertugliflozin work?
Ertugliflozin works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys. This action prevents the reabsorption of glucose back into the bloodstream, leading to increased glucose excretion through urine. As a result, blood sugar levels are lowered, helping to manage type 2 diabetes.
Is Ertugliflozin effective?
Ertugliflozin has been shown to effectively lower blood sugar levels in adults with type 2 diabetes when used in combination with diet and exercise. Clinical trials have demonstrated significant reductions in HbA1c levels, fasting plasma glucose, and body weight. Additionally, Ertugliflozin has been studied in combination with other diabetes medications, showing further improvements in glycemic control. These findings support its use as an effective treatment option for managing type 2 diabetes.
What is Ertugliflozin?
Ertugliflozin is used to manage blood sugar levels in adults with type 2 diabetes, alongside diet and exercise. It belongs to a class of medications called SGLT2 inhibitors, which work by helping the kidneys remove excess glucose from the body through urine. This process helps lower blood sugar levels and can also aid in weight loss.
Directions for Use
For how long do I take Ertugliflozin?
Ertugliflozin is typically used as a long-term treatment for managing type 2 diabetes. It is important to continue taking it as prescribed by your doctor, even if you feel well, as it helps maintain blood sugar levels over time. Regular monitoring and follow-up with your healthcare provider are essential to assess its effectiveness and make any necessary adjustments.
How do I take Ertugliflozin?
Ertugliflozin should be taken once daily in the morning, with or without food. There are no specific food restrictions while taking this medication, but it is important to follow a healthy diet as recommended by your doctor or dietitian. Consistent timing of the dose each day can help maintain stable blood sugar levels.
How long does it take for Ertugliflozin to start working?
Ertugliflozin begins to work shortly after ingestion, with its effects on blood sugar levels becoming noticeable within a few days. However, it may take several weeks to see the full benefits in terms of HbA1c reduction. Regular monitoring of blood sugar levels will help assess its effectiveness over time.
How should I store Ertugliflozin?
Ertugliflozin should be stored at room temperature, between 68°F to 77°F (20°C to 25°C), and kept in a dry place away from moisture. It is important to keep the medication in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom, as the humidity can affect the medication's stability.
What is the usual dose of Ertugliflozin?
The usual starting dose of Ertugliflozin for adults is 5 mg taken orally once daily, which can be increased to 15 mg if additional glycemic control is needed. Ertugliflozin is not recommended for use in children under 18 years of age, as its safety and effectiveness have not been established for this age group.
Warnings and Precautions
Can Ertugliflozin be taken safely while breastfeeding?
Ertugliflozin is not recommended while breastfeeding, as it is unknown if the drug passes into human milk and could potentially affect the nursing infant. Animal studies have shown that Ertugliflozin is present in the milk of lactating rats, which raises concerns about its safety during lactation. Consult your healthcare provider for alternative diabetes treatments if you are breastfeeding.
Can Ertugliflozin be taken safely while pregnant?
Ertugliflozin is not recommended during pregnancy due to potential risks to the developing fetus. Animal studies have shown adverse effects on renal development, and while there is limited data in humans, the potential for harm cannot be ruled out. If you are pregnant or planning to become pregnant, discuss alternative diabetes management options with your healthcare provider.
Can I take Ertugliflozin with other prescription drugs?
Ertugliflozin may increase the risk of hypoglycemia when used with insulin or insulin secretagogues. It can also interact with diuretics, potentially leading to dehydration and hypotension. Additionally, the use of SGLT2 inhibitors like Ertugliflozin may affect the pharmacokinetics of other drugs, so it is important to inform your doctor of all medications you are taking to avoid potential interactions.
Is Ertugliflozin safe for the elderly?
Elderly patients may be at an increased risk of volume depletion and renal impairment while taking Ertugliflozin. It is important to monitor renal function and volume status in older adults. Additionally, elderly patients should be cautious of symptoms like dizziness or lightheadedness, which may occur due to changes in blood pressure. Regular follow-up with a healthcare provider is recommended to ensure safe use of Ertugliflozin in this population.
Is it safe to drink alcohol while taking Ertugliflozin?
Drinking alcohol can affect blood sugar levels, which may interfere with the effectiveness of Ertugliflozin. It is important to discuss alcohol consumption with your doctor while taking this medication to ensure safe use and effective management of your diabetes.
Is it safe to exercise while taking Ertugliflozin?
Ertugliflozin does not specifically limit the ability to exercise. However, it may cause dizziness or lightheadedness, which could affect physical activity. If you experience these symptoms, it is important to exercise caution and consult your doctor to ensure safe exercise practices while taking this medication.
Who should avoid taking Ertugliflozin?
Ertugliflozin is contraindicated in patients with hypersensitivity to the drug, type 1 diabetes, or diabetic ketoacidosis. Important warnings include the risk of ketoacidosis, lower limb amputation, volume depletion, and serious urinary tract infections. Patients should be monitored for signs of these conditions and advised to seek medical attention if symptoms occur. It is also important to assess renal function before starting treatment and periodically thereafter.
