Erdafitinib
Transitional Cell Carcinoma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Erdafitinib
Summary
Erdafitinib is used to treat certain types of urothelial cancer that have spread or can't be removed by surgery. It's usually prescribed after other treatments have failed.
Erdafitinib works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps to slow or stop the spread of cancer cells.
The usual starting dose for adults is 8 mg taken orally once daily. This dose may be increased to 9 mg daily based on tolerability and serum phosphate levels. It's taken with or without food.
Common side effects include decreased appetite, nausea, diarrhea, vomiting, constipation, weight loss, blurred vision, and fatigue. More serious side effects can include ocular disorders and hyperphosphatemia.
Erdafitinib can harm an unborn baby, so effective contraception is necessary during treatment. It can also cause eye problems and increase phosphate levels. Patients should inform their doctor of any allergies or medical conditions.
Indications and Purpose
How does Erdafitinib work?
Erdafitinib works by blocking certain proteins in cancer cells that help them grow. It belongs to a class of drugs called kinase inhibitors. Think of it like turning off a switch that powers cancer cell growth. By blocking these proteins, Erdafitinib can slow or stop the growth of cancer cells. This helps treat certain types of cancer, such as bladder cancer with specific genetic mutations. Your doctor will monitor your response to ensure the medication is working effectively.
Is Erdafitinib effective?
Erdafitinib is effective for treating certain types of cancer, such as bladder cancer with specific genetic mutations. It works by blocking proteins that help cancer cells grow. Clinical studies show that Erdafitinib can shrink tumors and slow cancer progression in patients with these mutations. Your doctor will monitor your response to the medication through regular check-ups and tests. This helps ensure that Erdafitinib is working effectively for your condition.
What is Erdafitinib?
Erdafitinib is a medication used to treat certain types of cancer, such as bladder cancer with specific genetic mutations. It belongs to a class of drugs called kinase inhibitors, which work by blocking proteins that help cancer cells grow. By targeting these proteins, Erdafitinib can slow or stop the growth of cancer cells. This medication is typically used when other treatments have not been effective. Always follow your doctor's instructions when taking Erdafitinib.
Directions for Use
For how long do I take Erdafitinib?
Erdafitinib is usually a long-term medication for managing certain types of cancer. You'll typically take Erdafitinib every day as part of your cancer treatment plan unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Erdafitinib treatment to ensure your condition remains under control.
How do I dispose of Erdafitinib?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Erdafitinib?
Take Erdafitinib as prescribed by your doctor, usually once daily. You can take it with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Follow any specific dietary or beverage restrictions your doctor advises while on this medication.
How long does it take for Erdafitinib to start working?
Erdafitinib begins working in your body shortly after you take it, but the time to see full effects can vary. Some patients may notice improvements in symptoms within a few weeks, while others may take longer. The time it takes to work can depend on factors like your overall health and how your body responds to the medication. Regular check-ups with your doctor will help monitor your progress and adjust your treatment as needed.
How should I store Erdafitinib?
Store Erdafitinib tablets at room temperature, away from moisture and light. Keep the medication in its original container with the lid tightly closed. Avoid storing it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Erdafitinib out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication according to your healthcare provider's instructions.
What is the usual dose of Erdafitinib?
The usual starting dose of Erdafitinib for adults is 8 mg once daily. Your doctor may adjust your dose based on your response and side effects. The maximum recommended dose is 9 mg daily. Dose adjustments may be necessary for special populations, such as those with liver or kidney problems. Always follow your doctor's specific dosing instructions for your personal health needs. Do not change your dose without consulting your healthcare provider.
Warnings and Precautions
Can Erdafitinib be taken safely while breastfeeding?
Erdafitinib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. However, it may pose risks to a nursing infant. While we don't have specific reports of harm to breastfed babies from Erdafitinib, we can't rule out potential risks. If you're taking Erdafitinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Erdafitinib be taken safely while pregnant?
Erdafitinib isn't recommended during pregnancy. It may harm an unborn baby, as it can affect fetal development. We don't have much information about Erdafitinib use in pregnant women, but animal studies suggest potential risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Erdafitinib with other prescription drugs?
Erdafitinib can interact with other medications, increasing the risk of side effects or reducing its effectiveness. Major interactions include drugs that affect liver enzymes, which can alter Erdafitinib levels in your body. Always inform your doctor about all medications you're taking, including over-the-counter drugs and supplements. Your healthcare provider can help manage potential interactions and adjust your treatment plan to ensure safety and effectiveness.
Does Erdafitinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Erdafitinib can cause side effects like dry eyes, mouth sores, and increased phosphate levels. These effects vary in frequency and severity. Serious side effects include eye problems and high phosphate levels, which require immediate medical attention. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Erdafitinib and suggest appropriate management strategies.
Does Erdafitinib have any safety warnings?
Yes, Erdafitinib has important safety warnings. It can cause eye problems, so regular eye exams are necessary. It may also increase phosphate levels in your blood, requiring monitoring. Not adhering to these warnings can lead to serious complications, such as vision loss or other health issues. Always follow your doctor's instructions and report any new or worsening symptoms immediately. Your healthcare provider will guide you on how to manage these risks effectively.
Is Erdafitinib addictive?
Erdafitinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Erdafitinib works by targeting specific proteins in cancer cells, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Erdafitinib doesn't carry this risk while managing your health condition.
Is Erdafitinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Erdafitinib. This is because older adults often have other health conditions or take multiple medications, which can increase the risk of interactions and side effects. Erdafitinib can cause dehydration and affect kidney function, which are concerns for the elderly. Regular monitoring and communication with your healthcare provider are important to ensure the safe use of Erdafitinib in older adults.
Is it safe to drink alcohol while taking Erdafitinib?
It's best to avoid alcohol while taking Erdafitinib. Alcohol can increase the risk of side effects like dehydration, which means your body doesn't have enough fluids. This may worsen side effects of Erdafitinib like dizziness or low blood pressure. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Erdafitinib to get personalized advice.
Is it safe to exercise while taking Erdafitinib?
You can exercise while taking Erdafitinib, but keep a few things in mind. This medication can cause side effects like dizziness or fatigue, which might affect your ability to exercise. To exercise safely, drink plenty of water before, during, and after physical activity. Watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Most people can maintain their regular exercise routine while taking Erdafitinib, but check with your doctor if you have concerns.
Is it safe to stop Erdafitinib?
Stopping Erdafitinib suddenly can cause your cancer to progress. This medication is usually used long-term for chronic conditions like cancer. If you need to stop taking it, your doctor will guide you on how to do so safely. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Always talk with your doctor before stopping Erdafitinib to protect your health.
What are the most common side effects of Erdafitinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Erdafitinib include dry eyes, mouth sores, and increased phosphate levels in the blood. These effects vary from person to person. If you notice new symptoms after starting Erdafitinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. Your healthcare provider can help determine if these symptoms are related to Erdafitinib and suggest ways to manage them.
Who should avoid taking Erdafitinib?
Don't take Erdafitinib if you're allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Erdafitinib is not recommended for people with severe liver or kidney problems, as it may worsen these conditions. Pregnant or breastfeeding women should avoid this medication due to potential harm to the baby. Always consult your doctor about these concerns before starting Erdafitinib.
