Duvelisib
B-Cell Chronic Lymphocytic Leukemia
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Summary
Duvelisib is used to treat certain blood cancers, such as chronic lymphocytic leukemia and small lymphocytic lymphoma, which are types of cancer affecting the blood and lymph nodes.
Duvelisib works by blocking a protein called PI3K, which is involved in the growth and survival of cancer cells, helping to slow down or stop their growth.
The usual starting dose of Duvelisib for adults is 25 mg taken twice daily as a capsule, which should be swallowed whole without crushing or chewing.
Common side effects of Duvelisib include diarrhea, fatigue, and nausea, which are unwanted reactions that can occur when taking the medication.
Duvelisib can increase the risk of infections and liver problems, which are serious health issues. It should not be used if you have a known allergy to it or its ingredients.
Indications and Purpose
How does Duvelisib work?
Duvelisib works by inhibiting a protein called PI3K, which is involved in the growth and survival of cancer cells. By blocking this protein, Duvelisib helps slow down or stop the growth of cancer cells. Think of it like turning off a switch that cancer cells need to grow. This action makes Duvelisib effective in treating certain blood cancers.
Is Duvelisib effective?
Duvelisib is effective in treating certain types of blood cancers, such as chronic lymphocytic leukemia and small lymphocytic lymphoma. Clinical studies show that Duvelisib can help reduce cancer cell growth and improve patient outcomes. It works by inhibiting specific pathways that cancer cells use to grow. Your doctor will monitor your progress to ensure the medication is working effectively for your condition.
What is Duvelisib?
Duvelisib is a medication used to treat certain types of blood cancers, such as chronic lymphocytic leukemia and small lymphocytic lymphoma. It belongs to a class of drugs called PI3K inhibitors, which work by blocking specific pathways that cancer cells use to grow. This helps slow down or stop the growth of cancer cells. Duvelisib is usually used when other treatments have not been effective.
Directions for Use
For how long do I take Duvelisib?
Duvelisib is usually taken long-term for managing certain blood cancers. The duration of use depends on your response to the medication and any side effects you experience. Your doctor will determine how long you need to take Duvelisib based on your specific health needs. Always talk with your doctor before changing or stopping your Duvelisib treatment.
How do I dispose of Duvelisib?
To dispose of Duvelisib, take it to a drug take-back program or collection site at a pharmacy or hospital. If that's not possible, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Duvelisib?
Duvelisib is usually taken as a capsule twice daily, with or without food. Swallow the capsule whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions regarding your dosage and any dietary restrictions.
How long does it take for Duvelisib to start working?
Duvelisib begins working in your body shortly after you start taking it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary depending on your specific condition and overall health. Regular check-ups with your doctor will help monitor your progress and determine how well the medication is working for you.
How should I store Duvelisib?
Store Duvelisib at room temperature, away from moisture and light. Keep it in a tightly closed container. Avoid storing it in humid places like bathrooms. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Duvelisib out of children's reach to prevent accidental swallowing.
What is the usual dose of Duvelisib?
The usual starting dose of Duvelisib for adults is 25 mg taken twice daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. It's important to follow your doctor's specific dosing instructions. There are no established dose adjustments for children or the elderly, so always consult your healthcare provider for personalized advice.
Warnings and Precautions
Can Duvelisib be taken safely while breastfeeding?
Duvelisib is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk, but it may pose risks to a nursing infant. If you're taking Duvelisib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Duvelisib be taken safely while pregnant?
Duvelisib is not recommended during pregnancy due to potential risks to the unborn baby. There is limited information on its safety in pregnant women, but animal studies suggest possible harm. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options. Your doctor can help create a plan that protects both you and your baby.
Can I take Duvelisib with other prescription drugs?
Duvelisib can interact with other medications, increasing the risk of side effects or reducing effectiveness. It's important to inform your doctor about all the medications you're taking, including over-the-counter drugs and supplements. Your doctor can help manage potential interactions and adjust your treatment plan to ensure safety and effectiveness.
Does Duvelisib have adverse effects?
Adverse effects are unwanted reactions to a medication. Duvelisib can cause diarrhea, fatigue, and nausea, which are common side effects. Serious adverse effects include infections and liver problems. If you experience severe symptoms, contact your doctor immediately. Always inform your healthcare provider about any new or worsening symptoms while taking Duvelisib to ensure your treatment remains safe and effective.
Does Duvelisib have any safety warnings?
Yes, Duvelisib has important safety warnings. It can increase the risk of infections, including serious ones like pneumonia. It may also cause diarrhea, colitis, and liver problems. Monitoring your health and reporting any unusual symptoms to your doctor is crucial. Not adhering to these warnings can lead to severe health issues. Always follow your doctor's advice and attend regular check-ups while on Duvelisib.
Is Duvelisib addictive?
Duvelisib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Duvelisib works by affecting certain pathways in your body to treat cancer, and this mechanism doesn't lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Duvelisib doesn't carry this risk.
Is Duvelisib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Duvelisib, such as infections and liver problems. It's important for older adults to be closely monitored by their healthcare provider while taking this medication. Regular check-ups and lab tests can help manage any potential risks and ensure the treatment remains safe and effective.
Is it safe to drink alcohol while taking Duvelisib?
It's best to avoid alcohol while taking Duvelisib. Alcohol can increase the risk of liver problems and worsen side effects like dizziness or nausea. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like unusual fatigue or stomach pain. Talk with your doctor about alcohol use while taking Duvelisib for personalized advice.
Is it safe to exercise while taking Duvelisib?
You can exercise while taking Duvelisib, but be cautious. This medication can cause fatigue and dizziness, which might affect your exercise capacity. To exercise safely, stay hydrated and avoid strenuous activities if you feel weak. If you notice unusual symptoms during physical activity, slow down or stop and rest. Consult your doctor if you have concerns about exercising while on Duvelisib.
Is it safe to stop Duvelisib?
Stopping Duvelisib suddenly can cause your condition to worsen. It's used for long-term treatment of certain cancers, and stopping it without medical advice can lead to disease progression. Always talk with your doctor before stopping Duvelisib. They might suggest a gradual reduction or an alternative treatment to manage your condition safely.
What are the most common side effects of Duvelisib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Duvelisib include diarrhea, fatigue, and nausea. These effects vary from person to person. If you notice new symptoms after starting Duvelisib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Duvelisib?
Duvelisib should not be used if you have a known allergy to it or its ingredients. Serious allergic reactions require immediate medical help. Caution is needed if you have a history of infections or liver problems, as Duvelisib can worsen these conditions. Always consult your doctor about any concerns or pre-existing conditions before starting Duvelisib.
