Diflunisal
Rheumatoid Arthritis, Pain ... show more
.svg)
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug
Controlled Drug Substance
No
Diflunisal
Summary
Diflunisal is used to relieve pain and inflammation associated with osteoarthritis and rheumatoid arthritis. It's also used for mild to moderate pain relief from other causes, such as dental pain or muscle aches.
Diflunisal works by inhibiting the production of substances in the body called prostaglandins that cause pain, fever, and inflammation. This action helps reduce symptoms associated with conditions like arthritis and other types of pain.
For adults, the usual dose of Diflunisal for mild to moderate pain is an initial dose of 1000 mg followed by 500 mg every 12 hours. For osteoarthritis and rheumatoid arthritis, the dose ranges from 500 mg to 1000 mg daily in two divided doses.
Common side effects of Diflunisal include nausea, vomiting, diarrhea, constipation, headache, and dizziness. Serious adverse effects can include gastrointestinal bleeding, cardiovascular events, and liver or kidney issues.
Diflunisal carries a risk of serious cardiovascular events like heart attack and stroke, especially with long-term use. It can also cause gastrointestinal bleeding and ulcers. It's contraindicated in patients with known hypersensitivity to NSAIDs and should not be used after coronary artery bypass surgery.
Indications and Purpose
How does Diflunisal work?
Diflunisal works by inhibiting the production of prostaglandins, substances in the body that cause pain, fever, and inflammation. This action helps reduce symptoms associated with conditions like arthritis and other types of pain.
Is Diflunisal effective?
Clinical studies have shown that Diflunisal is effective in relieving pain and inflammation associated with osteoarthritis and rheumatoid arthritis. It works by inhibiting the production of substances in the body that cause pain and inflammation.
What is Diflunisal?
Diflunisal is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation associated with osteoarthritis and rheumatoid arthritis. It works by inhibiting the production of substances in the body that cause pain and inflammation. It's also used for mild to moderate pain relief from other causes.
Directions for Use
For how long do I take Diflunisal?
Diflunisal is used for both short-term and long-term treatment depending on the condition being treated. For pain relief, it may be used for a short duration, while for chronic conditions like arthritis, it may be used long-term. Always follow your doctor's guidance on duration.
How do I take Diflunisal?
Diflunisal should be taken with water, milk, or food to minimize stomach upset. There are no specific food restrictions, but it's advisable to avoid alcohol to reduce the risk of stomach bleeding. Always follow your doctor's instructions regarding dosage and administration.
How long does it take for Diflunisal to start working?
Diflunisal typically begins to relieve pain within 1 hour, with maximum effects occurring within 2 to 3 hours. However, it may take several days to feel the full benefit for chronic conditions like arthritis.
How should I store Diflunisal?
Store Diflunisal in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children to prevent accidental ingestion.
What is the usual dose of Diflunisal?
For adults, the usual dose of Diflunisal for mild to moderate pain is an initial dose of 1,000 mg followed by 500 mg every 12 hours. For osteoarthritis and rheumatoid arthritis, the dose ranges from 500 mg to 1,000 mg daily in two divided doses. The use of Diflunisal in children under 12 is not recommended.
Warnings and Precautions
Can Diflunisal be taken safely while breastfeeding?
Diflunisal is excreted in breast milk in small amounts. Due to the potential for serious adverse reactions in nursing infants, a decision should be made to either discontinue the drug or stop breastfeeding, considering the importance of the drug to the mother.
Can Diflunisal be taken safely while pregnant?
Diflunisal should be avoided during pregnancy, especially after 20 weeks, due to the risk of fetal harm, including premature closure of the ductus arteriosus and kidney issues. Consult your doctor for safer alternatives if you are pregnant or planning to become pregnant.
Can I take Diflunisal with other prescription drugs?
Diflunisal can interact with anticoagulants, other NSAIDs, SSRIs, SNRIs, and certain blood pressure medications, increasing the risk of bleeding and other side effects. Always inform your doctor of all medications you are taking to avoid harmful interactions.
Is Diflunisal safe for the elderly?
Elderly patients should use Diflunisal with caution due to an increased risk of gastrointestinal bleeding and kidney issues. It's important to use the lowest effective dose for the shortest duration possible. Regular monitoring by a healthcare provider is recommended.
Is it safe to drink alcohol while taking Diflunisal?
Drinking alcohol while taking Diflunisal can increase the risk of stomach bleeding. It's advisable to limit alcohol consumption to reduce this risk. Always consult your doctor for personalized advice.
Is it safe to exercise while taking Diflunisal?
Diflunisal does not specifically limit the ability to exercise. However, if you experience side effects like dizziness or fatigue, it may affect your ability to perform physical activities safely. Consult your doctor if you have concerns about exercising while on this medication.
Who should avoid taking Diflunisal?
Diflunisal carries a risk of serious cardiovascular events like heart attack and stroke, especially with long-term use. It can also cause gastrointestinal bleeding and ulcers. It's contraindicated in patients with known hypersensitivity to NSAIDs, and should not be used after coronary artery bypass surgery.
