Dicyclomine + Simethicone
Find more information about this combination medication at the webpages for dicyclomine and simethicone
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Dicyclomine is used to relieve muscle spasms in the stomach and intestines, often associated with irritable bowel syndrome, which involves abdominal pain and cramping. Simethicone is used to relieve symptoms of excess gas, such as bloating and discomfort. Together, they provide relief from digestive discomfort by addressing both muscle spasms and gas-related symptoms, offering a comprehensive approach to managing digestive issues effectively.
Dicyclomine works by relaxing the muscles in the stomach and intestines, which helps to relieve cramps and spasms associated with irritable bowel syndrome. Simethicone acts by breaking up gas bubbles in the gut, making it easier to pass gas and reducing bloating and discomfort. Together, these medicines provide a comprehensive approach to managing digestive symptoms by addressing both muscle spasms and gas-related discomfort.
The usual adult dose for dicyclomine is typically 20 mg taken four times a day, but it can be adjusted based on individual needs and response. Simethicone is usually taken in doses of 40 to 125 mg after meals and at bedtime, as needed, to relieve gas symptoms. When using these medicines together, it's important to follow the prescribed dosages and consult a healthcare provider for personalized advice.
Common side effects of dicyclomine include dry mouth, dizziness, blurred vision, and nausea. In rare cases, it can cause confusion or difficulty urinating. Simethicone is generally well-tolerated, with few reported side effects, but some people may experience mild digestive upset. When used together, the combination is usually safe, but users should be aware of dicyclomine's potential to cause drowsiness or dizziness.
Dicyclomine should not be used by individuals with certain conditions like glaucoma, myasthenia gravis, or severe ulcerative colitis, as it can worsen these conditions. It should also be used with caution in people with heart problems. Simethicone has no significant contraindications but should be used as directed. Always consult a healthcare provider before starting these medications, especially if you have pre-existing health conditions.
Indications and Purpose
How does combination of Dicyclomine and Simethicone work?
Dicyclomine works by blocking the action of acetylcholine, a neurotransmitter that causes muscle contractions, thereby relaxing the muscles in the gastrointestinal tract and relieving spasms. Simethicone acts as an anti-foaming agent, reducing the surface tension of gas bubbles in the gut, allowing them to combine and be expelled more easily. Both medications target gastrointestinal discomfort but through different mechanisms: Dicyclomine as a muscle relaxant and Simethicone as a gas reducer.
How effective is combination of Dicyclomine and Simethicone?
Clinical trials have shown that Dicyclomine is effective in reducing symptoms of irritable bowel syndrome, with a significant number of patients experiencing relief from abdominal pain and spasms. Simethicone's effectiveness is supported by its ability to reduce gas-related symptoms, as it helps break down gas bubbles in the digestive tract. Both medications have been proven to improve gastrointestinal comfort, though they work through different mechanisms: Dicyclomine as an anticholinergic and Simethicone as an anti-foaming agent.
Directions for Use
What is the usual dose of combination of Dicyclomine and Simethicone?
The usual adult daily dose for Dicyclomine is 20 mg taken four times a day, which can be increased to 40 mg four times a day if needed and tolerated. Simethicone is typically taken in doses of 40-125 mg after meals and at bedtime, as needed, to relieve symptoms of gas. Both medications are used to treat gastrointestinal issues, but Dicyclomine is specifically for irritable bowel syndrome, while Simethicone is for gas relief. They are both taken orally and can be adjusted based on individual patient needs.
How does one take combination of Dicyclomine and Simethicone?
Dicyclomine should be taken as directed by a healthcare provider, usually four times a day, and can be taken with or without food. Patients should avoid alcohol as it can increase drowsiness. Simethicone is typically taken after meals and at bedtime to relieve gas symptoms. There are no specific food restrictions for Simethicone, but it is important to follow the dosing instructions. Both medications should be taken as prescribed, and patients should consult their healthcare provider for any specific dietary advice.
For how long is combination of Dicyclomine and Simethicone taken?
Dicyclomine is typically used for short-term relief of irritable bowel syndrome symptoms, with treatment duration often limited to two weeks if no improvement is seen. Simethicone can be used as needed for gas relief, with no specific duration of use, as it is generally considered safe for longer-term use. Both medications are used to manage gastrointestinal symptoms, but Dicyclomine's use is more restricted due to potential side effects, while Simethicone can be used more flexibly.
How long does it take for combination of Dicyclomine and Simethicone to work?
Dicyclomine typically starts working within 60-90 minutes after oral administration. It is absorbed quickly and distributed throughout the body, providing relief from muscle spasms in the gastrointestinal tract. Simethicone, on the other hand, works by breaking up gas bubbles in the gut, providing relief from bloating and discomfort. The onset of action for Simethicone is usually within a few minutes to an hour. Both medications are used to alleviate symptoms related to gastrointestinal discomfort, but they work through different mechanisms: Dicyclomine as an anticholinergic and Simethicone as an anti-foaming agent.
Warnings and Precautions
Are there harms and risks from taking combination of Dicyclomine and Simethicone?
Common side effects of Dicyclomine include dry mouth, dizziness, blurred vision, and drowsiness. Serious adverse effects can include confusion, hallucinations, and difficulty breathing. Simethicone is generally well-tolerated, with few reported side effects, though some may experience mild gastrointestinal discomfort. Both medications aim to relieve gastrointestinal symptoms, but Dicyclomine has a higher risk of side effects due to its anticholinergic properties, while Simethicone is considered safer with minimal adverse effects.
Can I take combination of Dicyclomine and Simethicone with other prescription drugs?
Dicyclomine can interact with other anticholinergic drugs, increasing the risk of side effects like dry mouth and blurred vision. It may also interact with medications that affect the central nervous system, such as sedatives and antidepressants. Simethicone has minimal drug interactions, making it safe to use with most medications. Both medications should be used with caution, and patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Can I take combination of Dicyclomine and Simethicone if I am pregnant?
Dicyclomine should be used during pregnancy only if clearly needed, as there are no well-controlled studies in pregnant women. However, animal studies have not shown harm to the fetus. Simethicone is generally considered safe during pregnancy, as it is not absorbed into the bloodstream. Both medications should be used under medical supervision during pregnancy, with Dicyclomine requiring more caution due to its potential effects on the fetus.
Can I take combination of Dicyclomine and Simethicone while breastfeeding?
Dicyclomine is contraindicated during breastfeeding as it is excreted in breast milk and may cause serious adverse effects in infants, such as respiratory issues. Simethicone is generally considered safe during breastfeeding, as it is not absorbed into the bloodstream and thus not excreted in breast milk. Both medications require consideration of the risks and benefits, but Dicyclomine poses a higher risk to nursing infants compared to Simethicone.
Who should avoid taking combination of Dicyclomine and Simethicone?
Dicyclomine is contraindicated in patients with glaucoma, myasthenia gravis, and severe ulcerative colitis due to its anticholinergic effects. It should be used with caution in elderly patients and those with cardiovascular conditions. Simethicone has no major contraindications but should be used as directed. Both medications require careful use in specific populations, and patients should inform their healthcare provider of their medical history to avoid potential risks. Dicyclomine's anticholinergic properties necessitate more caution compared to Simethicone.
