Dicyclomine + Paracetamol
Find more information about this combination medication at the webpages for Dicyclomine and Paracetamol
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Advisory
- This medicine contains a combination of 2 drugs Dicyclomine and Paracetamol.
- Each of these drugs treats a different disease or symptom.
- Treating different diseases with different medicines allows doctors to adjust the dose of each medicine separately. This prevents overmedication or undermedication.
- Most doctors advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Anticholinergic
Controlled Drug Substance
NO
Dicyclomine + Paracetamol
Summary
Dicyclomine is primarily used to treat irritable bowel syndrome (IBS), which is a condition that causes abdominal pain and discomfort due to muscle spasms in the gut. Paracetamol is used to relieve mild to moderate pain, such as headaches and muscle aches, and to reduce fever. It is versatile and can be used for various conditions that involve pain and fever.
Dicyclomine works by blocking acetylcholine, a neurotransmitter that causes muscle contractions in the gut, which helps reduce spasms and discomfort. Paracetamol works by inhibiting the production of prostaglandins in the brain, which are chemicals that cause pain and fever. While Dicyclomine targets the gastrointestinal tract, Paracetamol affects the central nervous system.
The usual adult dose for Dicyclomine is 20 mg taken four times a day, which can be increased to 40 mg four times a day if needed. It is typically taken orally before meals. For Paracetamol, the typical adult dose is 500 mg to 1,000 mg every 4 to 6 hours, not exceeding 4,000 mg in a 24-hour period. It can be taken orally with or without food.
Common side effects of Dicyclomine include dry mouth, dizziness, blurred vision, and constipation. Paracetamol is generally well-tolerated, but common side effects can include nausea and rash. Significant adverse effects for Dicyclomine may include confusion and increased heart rate, while for Paracetamol, liver damage can occur, especially with overdose or prolonged use.
Dicyclomine should not be used in individuals with obstructive uropathy, severe ulcerative colitis, or myasthenia gravis due to its anticholinergic effects. It should be used cautiously in patients with glaucoma and heart conditions. Paracetamol should be used cautiously in individuals with liver disease and should not exceed the recommended dose to avoid liver damage. Both medicines require careful consideration of existing health conditions and adherence to dosing guidelines to prevent adverse effects.
Indications and Purpose
How does combination of Dicyclomine and Paracetamol work?
Dicyclomine works by blocking the activity of acetylcholine, a natural substance in the body, which helps relieve muscle spasms in the gastrointestinal tract. Paracetamol works by inhibiting the production of prostaglandins in the brain, which helps reduce pain and fever. Both medications act to alleviate symptoms, with Dicyclomine focusing on muscle relaxation and Paracetamol on pain and fever reduction. Together, they provide a comprehensive approach to managing symptoms related to irritable bowel syndrome and pain.
How effective is combination of Dicyclomine and Paracetamol?
Clinical trials and extensive use have demonstrated the effectiveness of Dicyclomine in relieving symptoms of irritable bowel syndrome by reducing gastrointestinal muscle spasms. Paracetamol's efficacy in reducing pain and fever is well-documented, with numerous studies supporting its use for mild to moderate pain relief. Both medications have been proven effective in their respective areas, with Dicyclomine focusing on gastrointestinal relief and Paracetamol on general pain and fever reduction. Their effectiveness is supported by clinical evidence and widespread clinical use.
Directions for Use
What is the usual dose of combination of Dicyclomine and Paracetamol?
For Dicyclomine, the usual adult dose is 20 mg taken four times a day, which can be increased to 40 mg four times a day if needed. For Paracetamol, the typical adult dose is 500 mg to 1000 mg every 4 to 6 hours, not exceeding 4000 mg per day. Both medications require careful adherence to dosing instructions to avoid side effects. Dicyclomine is used for muscle spasms in the gastrointestinal tract, while Paracetamol is used for pain and fever relief. Both should be taken as directed by a healthcare provider.
How does one take combination of Dicyclomine and Paracetamol?
Dicyclomine can be taken with or without food, but it is important to follow the prescribed schedule and not exceed the recommended dose. Paracetamol can also be taken with or without food, but it is crucial to adhere to the dosing instructions and not exceed 4000 mg per day. Both medications do not have specific food restrictions, but alcohol should be avoided with Paracetamol due to the risk of liver damage. It's important to follow any additional instructions provided by a healthcare provider.
For how long is combination of Dicyclomine and Paracetamol taken?
Dicyclomine is typically used for short-term relief of irritable bowel syndrome symptoms, with treatment duration often limited to two weeks if no improvement is seen. Paracetamol can be used for short-term relief of pain and fever, with usage generally not exceeding 10 days for pain or 3 days for fever without consulting a doctor. Both medications are intended for short-term use to manage symptoms effectively, and prolonged use should be under medical supervision to avoid potential side effects.
How long does it take for combination of Dicyclomine and Paracetamol to work?
Dicyclomine typically starts working within 60-90 minutes after oral administration, as it is rapidly absorbed. It relieves muscle spasms in the gastrointestinal tract. Paracetamol, on the other hand, is absorbed quickly and reaches peak plasma concentrations within 30 to 60 minutes, providing pain relief and reducing fever. Both medications are fast-acting, with Dicyclomine focusing on muscle relaxation and Paracetamol on pain and fever reduction. Together, they provide a comprehensive approach to managing symptoms related to irritable bowel syndrome and pain.
Warnings and Precautions
Are there harms and risks from taking combination of Dicyclomine and Paracetamol?
Common side effects of Dicyclomine include dry mouth, dizziness, blurred vision, and drowsiness. Serious side effects can include confusion, hallucinations, and difficulty breathing. Paracetamol is generally well-tolerated, but can cause liver damage if taken in excessive amounts. Serious side effects include skin reactions like rash and blisters. Both medications can cause adverse effects if not taken as directed, with Dicyclomine affecting the nervous system and Paracetamol posing a risk to the liver. Monitoring and adherence to dosing are crucial for safety.
Can I take combination of Dicyclomine and Paracetamol with other prescription drugs?
Dicyclomine can interact with other anticholinergic drugs, increasing the risk of side effects like dry mouth and blurred vision. It may also interact with medications for heart conditions, such as beta-blockers. Paracetamol can interact with blood thinners like warfarin, increasing the risk of bleeding. Both medications require careful monitoring when used with other drugs that affect the liver or nervous system. It is important to inform healthcare providers of all medications being taken to avoid potential interactions and ensure safe use.
Can I take combination of Dicyclomine and Paracetamol if I am pregnant?
Dicyclomine should be used with caution during pregnancy, especially in the third trimester, due to potential risks to the fetus. Paracetamol is generally considered safe for use during pregnancy when used at recommended doses, as it has not been associated with an increased risk of birth defects. Both medications should be used under medical supervision during pregnancy, with Paracetamol being the preferred choice for pain and fever relief. Pregnant women should consult their healthcare providers before using these medications to ensure safety.
Can I take combination of Dicyclomine and Paracetamol while breastfeeding?
Dicyclomine is contraindicated for breastfeeding mothers as it is excreted in breast milk and may cause serious adverse effects in infants. Paracetamol is generally considered safe during breastfeeding, as it is excreted in breast milk in small amounts and has not been associated with adverse effects in nursing infants. While Paracetamol can be used with caution, Dicyclomine should be avoided during lactation. It is important for breastfeeding mothers to consult healthcare providers before using these medications to ensure the safety of their infants.
Who should avoid taking combination of Dicyclomine and Paracetamol?
Dicyclomine is contraindicated in patients with glaucoma, myasthenia gravis, and severe ulcerative colitis due to its anticholinergic effects. Paracetamol should not be used in excessive doses due to the risk of severe liver damage. Both medications should be used with caution in patients with liver disease. It is important to adhere to dosing instructions and avoid alcohol with Paracetamol. Patients should consult healthcare providers before use, especially if they have pre-existing conditions or are taking other medications.
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