Deutetrabenazine
Chorea, Tardive Dyskinesia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Deutetrabenazine
Summary
Deutetrabenazine is used to treat involuntary movements associated with Huntington's disease and tardive dyskinesia. These conditions can greatly affect a person's quality of life, and this medication helps manage these symptoms.
Deutetrabenazine works by inhibiting a transporter in the brain called VMAT2. This reduces the uptake of certain chemicals like dopamine into parts of the nerve cells called synaptic vesicles, helping to decrease the excessive movements associated with conditions like Huntington's disease and tardive dyskinesia.
For adults, the starting dose of Deutetrabenazine is typically 6 mg taken twice daily. The dose can be increased weekly by 6 mg per day up to a maximum of 48 mg per day. The medication is taken orally.
Common side effects of Deutetrabenazine include drowsiness, diarrhea, and dry mouth. Serious side effects can include depression, suicidal thoughts, and a condition called neuroleptic malignant syndrome. If you experience any severe side effects, seek medical attention immediately.
Deutetrabenazine may increase the risk of depression and suicidal thoughts, especially in patients with Huntington's disease. It's not recommended for patients with untreated depression, suicidal ideation, or liver impairment. Regular monitoring for mood changes is essential.
Indications and Purpose
How does Deutetrabenazine work?
Deutetrabenazine acts by inhibiting the vesicular monoamine transporter 2 (VMAT2), which reduces the uptake of monoamines like dopamine into synaptic vesicles, leading to decreased monoamine levels and helping control involuntary movements.
Is Deutetrabenazine effective?
Clinical trials have shown that Deutetrabenazine effectively reduces chorea in Huntington's disease and involuntary movements in tardive dyskinesia. Patients reported significant improvements in symptoms compared to placebo, supporting its efficacy.
What is Deutetrabenazine?
Deutetrabenazine is used to treat involuntary movements in Huntington's disease and tardive dyskinesia. It works by inhibiting VMAT2, reducing the uptake of monoamines like dopamine in the brain, which helps control abnormal movements.
Directions for Use
For how long do I take Deutetrabenazine?
The duration of Deutetrabenazine use varies based on individual needs and response to treatment. It is typically used long-term for managing symptoms of Huntington's disease and tardive dyskinesia, but the exact duration should be determined by a healthcare provider.
How do I take Deutetrabenazine?
Deutetrabenazine tablets should be taken with food, while the extended-release form can be taken with or without food. There are no specific food restrictions, but alcohol should be avoided to prevent increased drowsiness.
How long does it take for Deutetrabenazine to start working?
Deutetrabenazine may start to show effects within a few days to weeks, but it may take several weeks to achieve the full therapeutic effect. Regular follow-up with a healthcare provider is important to monitor progress.
How should I store Deutetrabenazine?
Store Deutetrabenazine at room temperature, away from light, moisture, and heat. Keep it in its original container, tightly closed, and out of reach of children to prevent accidental ingestion.
What is the usual dose of Deutetrabenazine?
For adults, the usual starting dose of Deutetrabenazine is 6 mg twice daily, which can be increased weekly by 6 mg per day, up to a maximum of 48 mg per day. The extended-release form is taken once daily. The safety and effectiveness of Deutetrabenazine in children have not been established.
Warnings and Precautions
Can Deutetrabenazine be taken safely while breastfeeding?
There is no data on the presence of Deutetrabenazine in human milk or its effects on the breastfed infant. The benefits of breastfeeding should be weighed against the mother's need for the medication and any potential risks to the infant.
Can Deutetrabenazine be taken safely while pregnant?
There is no adequate data on the use of Deutetrabenazine in pregnant women. Animal studies with a related drug showed increased stillbirths and postnatal mortality. Pregnant women should use it only if the potential benefit justifies the potential risk to the fetus.
Can I take Deutetrabenazine with other prescription drugs?
Deutetrabenazine should not be used with MAO inhibitors, reserpine, or other VMAT2 inhibitors like tetrabenazine. Caution is advised when used with strong CYP2D6 inhibitors, as they can increase the drug's effects and side effects.
Is Deutetrabenazine safe for the elderly?
Elderly patients should use Deutetrabenazine with caution, starting at the lower end of the dosing range due to the increased likelihood of liver, kidney, or heart issues, and potential interactions with other medications. Regular monitoring by a healthcare provider is recommended.
Is it safe to drink alcohol while taking Deutetrabenazine?
Drinking alcohol while taking Deutetrabenazine can increase drowsiness and sedation, which are side effects of the medication. It is advised to avoid alcohol to prevent these enhanced effects and ensure safety.
Is it safe to exercise while taking Deutetrabenazine?
Deutetrabenazine may cause drowsiness, fatigue, and dizziness, which could potentially limit the ability to exercise safely. If you experience these symptoms, it is advisable to avoid strenuous activities and consult your doctor for guidance.
Who should avoid taking Deutetrabenazine?
Deutetrabenazine may increase the risk of depression and suicidal thoughts, especially in patients with Huntington's disease. It is contraindicated in patients with untreated depression, liver impairment, or those taking MAO inhibitors. Regular monitoring for mood changes is essential.
