Delafloxacin
Escherichia coli Infections, Bacterial Skin Diseases ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Fluoroquinolone Antibacterial
Controlled Drug Substance
No
Delafloxacin
Summary
Delafloxacin is an antibiotic used to treat acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP) in adults. It is effective against certain bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and other susceptible microorganisms.
Delafloxacin works by inhibiting bacterial enzymes necessary for DNA replication, transcription, repair, and recombination. This action stops bacterial growth and prevents bacteria from multiplying and spreading, effectively treating bacterial infections.
For adults, the usual dose of Delafloxacin is 450 mg taken orally every 12 hours, or 300 mg given intravenously every 12 hours. The duration of treatment is typically 5 to 14 days for skin infections and 5 to 10 days for pneumonia. This medication is not recommended for use in children under 18 years of age.
Common side effects of Delafloxacin include nausea, diarrhea, headache, and vomiting. Serious adverse effects include tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects such as seizures and hallucinations.
Delafloxacin carries a risk of tendinitis and tendon rupture, peripheral neuropathy, and central nervous system effects. It may also exacerbate muscle weakness in patients with myasthenia gravis. It is contraindicated in patients with known hypersensitivity to fluoroquinolones and should be avoided in those with a history of tendon disorders.
Indications and Purpose
How does Delafloxacin work?
Delafloxacin works by inhibiting bacterial enzymes needed for DNA replication, which stops bacteria from multiplying. Think of it like cutting off the power supply to a factory, halting production. This action helps clear the infection. Delafloxacin is effective against a range of bacteria, making it useful for treating various infections.
Is Delafloxacin effective?
Delafloxacin is effective in treating bacterial infections, particularly skin infections. It works by killing bacteria, helping to clear the infection. Clinical studies support its effectiveness in improving health outcomes for people with these infections. Always take it as prescribed for the best results.
What is Delafloxacin?
Delafloxacin is an antibiotic used to treat bacterial infections, particularly skin infections. It belongs to the fluoroquinolone class, which works by killing bacteria. Delafloxacin is effective against a variety of bacteria and is used when other antibiotics may not be suitable. Always take it as prescribed by your doctor.
Directions for Use
For how long do I take Delafloxacin?
Delafloxacin is usually prescribed for short-term use to treat acute infections. The duration depends on the type and severity of the infection. Always complete the full course as prescribed by your doctor, even if you feel better. Consult your doctor for specific guidance on your treatment duration.
How do I dispose of Delafloxacin?
Bring unused Delafloxacin to a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take Delafloxacin?
Take Delafloxacin as prescribed by your doctor. It's usually taken twice daily, with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Delafloxacin to start working?
Delafloxacin starts working shortly after you take it, but you may not notice improvement in symptoms for a few days. The full therapeutic effect can take several days, depending on the infection's severity. Factors like your overall health and the type of infection can affect how quickly it works. Take it as prescribed for the best results.
How should I store Delafloxacin?
Store Delafloxacin at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in humid places like bathrooms. Always keep it out of reach of children. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Delafloxacin?
The usual starting dose of Delafloxacin for adults is 450 mg taken orally every 12 hours. The maximum recommended dose is 900 mg per day. Always follow your doctor's specific dosing instructions, as they may adjust your dose based on your health needs.
Warnings and Precautions
Can Delafloxacin be taken safely while breastfeeding?
Delafloxacin is not recommended while breastfeeding due to limited safety data. It's unclear if it passes into breast milk or affects the infant. If you're breastfeeding, talk with your doctor about safer medication options.
Can Delafloxacin be taken safely while pregnant?
Delafloxacin is not recommended during pregnancy due to limited safety data. Animal studies suggest potential risks, but human data is lacking. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options.
Can I take Delafloxacin with other prescription drugs?
Delafloxacin can interact with drugs like antacids containing magnesium or aluminum, which can reduce its effectiveness. It may also interact with blood thinners, increasing bleeding risk. Always inform your doctor about all medications you're taking to avoid potential interactions.
Does Delafloxacin have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Delafloxacin include nausea, diarrhea, and headache. Serious side effects can include tendon rupture and nerve damage. If you experience severe side effects, contact your doctor immediately. Always inform your doctor about any new or worsening symptoms.
Does Delafloxacin have any safety warnings?
Yes, Delafloxacin has safety warnings. It may increase the risk of tendonitis and tendon rupture, especially in older adults. It can also cause nerve damage, leading to tingling or numbness. If you experience these symptoms, contact your doctor immediately. Not adhering to these warnings can lead to serious health issues.
Is Delafloxacin addictive?
Delafloxacin is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works by killing bacteria and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Delafloxacin safe for the elderly?
Elderly patients are more vulnerable to side effects like tendon rupture and nerve damage when taking Delafloxacin. They may also have kidney issues affecting drug clearance. Doctors may adjust the dose for safety. Always consult your doctor about the risks and benefits of using Delafloxacin if you're elderly.
Is it safe to drink alcohol while taking Delafloxacin?
It's best to avoid alcohol while taking Delafloxacin. Alcohol can increase the risk of side effects like dizziness and upset stomach. If you choose to drink, limit your intake and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while on this medication.
Is it safe to exercise while taking Delafloxacin?
You can exercise while taking Delafloxacin, but be cautious. This medication can cause tendonitis or tendon rupture, especially in the Achilles tendon. Avoid high-impact sports or strenuous activities. If you experience pain or swelling in your tendons, stop exercising and contact your doctor.
Is it safe to stop Delafloxacin?
Delafloxacin is usually prescribed for short-term use to treat infections. Stopping it early can lead to the infection returning or worsening. Always complete the full course as prescribed by your doctor, even if you feel better. If you have concerns about stopping the medication, consult your doctor.
What are the most common side effects of Delafloxacin?
Side effects are unwanted reactions to a medication. Common side effects of Delafloxacin include nausea, diarrhea, and headache. These effects vary from person to person. If you notice new symptoms after starting Delafloxacin, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Delafloxacin?
Don't take Delafloxacin if you're allergic to it or its ingredients. It's contraindicated in people with a history of tendon disorders related to fluoroquinolone use. Caution is needed in patients with kidney problems. Always consult your doctor about these concerns.
