Danazol
Endometriosis, Fibrocystic Breast Disease
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Androgen
Controlled Drug Substance
No
Danazol
Summary
Danazol is used to treat endometriosis, a condition where tissue similar to the lining of the uterus grows outside the uterus. It's also used to treat fibrocystic breast disease, breast pain and to prevent swelling in the skin, abdomen, or throat (angioedema) in both men and women.
Danazol works by blocking signals from the brain to the ovaries, reducing the production of hormones that can worsen conditions like endometriosis and breast pain. It also interacts with hormone receptors in the body, preventing them from functioning properly.
For people with mild symptoms, the recommended starting dose is 200 to 400 mg per day, split into two doses. It is taken orally with food or after a meal to reduce stomach upset.
Common side effects include weight gain, acne, oily skin, changes in menstrual cycles, and hot flashes. More serious side effects can include liver toxicity, elevated cholesterol levels, masculinization in women, mood changes, and fluid retention.
Danazol should not be used during pregnancy or breastfeeding, as it can harm the baby. It's also contraindicated in individuals with liver disease, porphyria, and severe heart or kidney disease. Caution is needed in those with a history of blood clots.
Indications and Purpose
How does Danazol work?
Danazol works by altering hormone levels in the body. It belongs to a class of drugs called androgens, which are male hormones. Danazol suppresses the production of certain hormones, like estrogen, which helps reduce symptoms of conditions like endometriosis and fibrocystic breast disease. Think of it like turning down the volume on a radio; Danazol lowers the "volume" of hormone activity, which helps manage symptoms. This medication can also prevent attacks of hereditary angioedema by stabilizing cell membranes.
Is Danazol effective?
Danazol is effective for treating conditions like endometriosis and fibrocystic breast disease. It works by altering hormone levels, which helps reduce symptoms like pain and swelling. Clinical studies support its effectiveness in managing these conditions. However, individual responses can vary. Some people experience significant relief, while others may need additional treatments. Regular follow-ups with your doctor are important to monitor your progress and adjust your treatment plan as needed. Always discuss any concerns about effectiveness with your healthcare provider.
What is Danazol?
Danazol is a medication used to treat conditions like endometriosis and fibrocystic breast disease. It belongs to a class of drugs called androgens, which are male hormones. Danazol works by altering hormone levels in the body, which helps reduce symptoms like pain and swelling. It's also used to prevent attacks of hereditary angioedema, which is a condition that causes swelling in various parts of the body. Danazol is usually used as part of a comprehensive treatment plan, often alongside other therapies.
Directions for Use
For how long do I take Danazol?
Danazol is typically used for short-term treatment of conditions like endometriosis or fibrocystic breast disease. The usual duration of use is three to six months, but this can vary based on your response and any side effects. Your doctor will determine the appropriate length of treatment for your specific condition. It's important to follow your doctor's instructions and not stop taking Danazol without their guidance. They will help ensure your treatment is effective and safe.
How do I dispose of Danazol?
To dispose of Danazol, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. Always keep medications out of reach of children and pets.
How do I take Danazol?
Take Danazol exactly as your doctor prescribes. It's usually taken two to four times a day. You can take it with or without food, but try to take it the same way each time. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not double up on doses. Always follow your doctor's specific instructions regarding your treatment.
How long does it take for Danazol to start working?
Danazol may start to work within a few days to weeks, but the full therapeutic effect can take several months. The time it takes to notice improvements can vary based on the condition being treated and individual factors like your overall health. For endometriosis, you might see a reduction in pain and menstrual symptoms within a few weeks. For fibrocystic breast disease, it may take longer to notice changes. Always take Danazol as prescribed and discuss any concerns about its effectiveness with your doctor.
How should I store Danazol?
Store Danazol at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, as moisture can affect its effectiveness. Danazol does not require refrigeration. Always keep it out of reach of children and pets to prevent accidental ingestion. Regularly check the expiration date and properly dispose of any unused or expired medication. Follow your pharmacist's instructions for safe storage.
What is the usual dose of Danazol?
The usual starting dose of Danazol for adults varies depending on the condition being treated. For endometriosis, the typical dose is 200 to 400 mg daily, divided into two doses. For fibrocystic breast disease, it's usually 100 to 400 mg daily. The dose may be adjusted based on your response and any side effects. The maximum recommended dose is 800 mg per day. Danazol is not typically used in children. Elderly patients may require careful monitoring. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can Danazol be taken safely while breastfeeding?
Danazol is not recommended while breastfeeding. It can pass into breast milk and may affect the nursing infant. The potential risks to the baby include hormonal effects and developmental issues. If you're taking Danazol and want to breastfeed, talk with your doctor about safer medication options. They can help you find a treatment that allows you to nurse your baby safely. Always discuss any concerns about medication use during breastfeeding with your healthcare provider.
Can Danazol be taken safely while pregnant?
Danazol is not safe to use during pregnancy. It can harm the unborn baby, potentially causing birth defects. If you're pregnant or planning to become pregnant, talk with your doctor about alternative treatments. They can help create a pregnancy-specific treatment plan that protects both you and your baby. If you become pregnant while taking Danazol, contact your healthcare provider immediately. They will provide guidance on how to proceed safely.
Can I take Danazol with other prescription drugs?
Danazol can interact with several prescription drugs. It may increase the effects of blood thinners like warfarin, which can lead to bleeding risks. Danazol can also interact with statins, which are medications used to lower cholesterol, increasing the risk of muscle damage. Additionally, it may affect the levels of certain anti-seizure medications. Always inform your doctor about all medications you're taking to avoid potential interactions. They can adjust your treatment plan to ensure safety and effectiveness.
Does Danazol have adverse effects?
Yes, Danazol can have adverse effects, which are unwanted reactions to a medication. Common adverse effects include weight gain, acne, and changes in menstrual cycles. These effects vary in frequency and severity. Serious side effects can include liver problems, blood clots, and changes in cholesterol levels. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Danazol and recommend appropriate actions to manage them.
Does Danazol have any safety warnings?
Yes, Danazol has important safety warnings. It can cause liver problems, which may lead to liver damage. Regular liver function tests are recommended. Danazol can also affect cholesterol levels, increasing the risk of heart disease. It may cause blood clots, which can lead to serious conditions like stroke. Women may experience changes in menstrual cycles or develop male characteristics, which are called virilization. Not adhering to these warnings can lead to severe health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is Danazol addictive?
No, Danazol is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Danazol works by affecting hormone levels in the body, but it doesn't impact brain chemistry in a way that leads to addiction. You won't experience cravings for Danazol or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Danazol doesn't carry this risk while managing your health condition.
Is Danazol safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Danazol, such as liver problems or changes in cholesterol levels. These risks require careful monitoring by a healthcare provider. Danazol can be used in the elderly, but doctors may start with a lower dose and adjust as needed. Regular check-ups are important to ensure the medication is working safely. If you're an older adult taking Danazol, discuss any concerns with your doctor to ensure your treatment is appropriate.
Is it safe to drink alcohol while taking Danazol?
It's best to avoid alcohol while taking Danazol. Alcohol can increase the risk of liver damage, which is a potential side effect of Danazol. Drinking alcohol may also worsen other side effects like dizziness or stomach upset. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs like nausea or abdominal pain. Talk with your doctor about alcohol use while taking Danazol to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Danazol?
Yes, you can exercise while taking Danazol, but be mindful of how your body feels. Danazol can cause side effects like dizziness or fatigue, which might affect your exercise capacity. If you experience these symptoms, consider reducing the intensity of your workouts or taking breaks as needed. Stay hydrated and listen to your body. If you notice any unusual symptoms during physical activity, slow down or stop exercising and rest. Always consult your doctor if you have concerns about exercising while on Danazol.
Is it safe to stop Danazol?
It's important to talk with your doctor before stopping Danazol. This medication is often used for specific conditions like endometriosis or fibrocystic breast disease, and stopping it suddenly may cause symptoms to return or worsen. There are no known withdrawal symptoms, but your doctor may suggest gradually reducing your dose to prevent any potential issues. Always follow your doctor's advice when making changes to your medication regimen to ensure your health condition remains well-managed.
What are the most common side effects of Danazol?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Danazol include weight gain, acne, and changes in menstrual cycles. These effects vary from person to person. Some people may experience mild side effects, while others may have more noticeable reactions. If you notice new symptoms after starting Danazol, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. They can help determine if the side effects are related to Danazol and suggest ways to manage them.
Who should avoid taking Danazol?
Danazol has several important contraindications. Do not use it if you're pregnant, as it can harm the unborn baby. It's also contraindicated in people with severe liver, kidney, or heart problems, as it can worsen these conditions. Danazol should not be used by individuals with a history of blood clots or certain types of cancer. Always inform your doctor of your medical history before starting Danazol. They can determine if it's safe for you and discuss any potential risks.
Forms / Brands
