Dalfampridine
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Potassium Channel Blocker
Controlled Drug Substance
No
Dalfampridine
Summary
Dalfampridine is used to improve walking speed in adults with multiple sclerosis (MS). It doesn't treat the disease itself or prevent relapses, but can help with mobility and physical function.
Dalfampridine works by blocking potassium channels in nerve cells. This allows damaged nerve fibers in MS patients to conduct signals more efficiently, improving muscle function and walking ability.
The usual dose for adults is 10 mg twice daily, taken approximately 12 hours apart. It's taken orally, and the tablets should not be crushed, split, or chewed. Doses above 20 mg per day are not recommended due to the risk of seizures.
Common side effects include urinary tract infections, dizziness, nausea, insomnia, and headache. Some people may also experience mood changes, loss of appetite, or sleep disturbances. If severe reactions occur, seek medical help immediately.
People with a history of seizures, moderate to severe kidney disease, or allergy to Dalfampridine should avoid it. It should be used cautiously in patients with mild kidney issues, as it increases seizure risk. It's not recommended for breastfeeding women due to the risk of seizures and neurological effects.
Indications and Purpose
How does Dalfampridine work?
Dalfampridine blocks potassium channels in nerve cells, allowing damaged nerve fibers in MS patients to conduct signals more efficiently. This helps improve muscle function and walking ability.
Is Dalfampridine effective?
Yes, clinical trials have shown dalfampridine increases walking speed in about 35-45% of MS patients. However, it does not work for everyone. Your doctor will monitor your progress to see if it benefits you.
What is Dalfampridine?
Dalfampridine is a medication used to improve walking ability in people with multiple sclerosis (MS). It works by blocking potassium channels, helping nerve signals travel more efficiently. It does not cure MS but can enhance mobility in some patients. It is available as extended-release tablets and is taken orally.
Directions for Use
For how long do I take Dalfampridine?
Dalfampridine is taken long-term as long as it provides walking improvement without serious side effects. Your doctor will assess your response after 2-4 weeks. If there is no benefit, treatment may be discontinued.
How do I take Dalfampridine?
Take dalfampridine with or without food, swallowing the tablet whole with water. Avoid crushing, breaking, or chewing the tablet, as this can increase the risk of side effects like seizures. Take each dose exactly 12 hours apart.
How long does it take for Dalfampridine to start working?
Most patients notice an improvement in walking ability within 2 to 6 weeks. However, some may take longer to respond, and others may not experience significant benefits.
How should I store Dalfampridine?
Store dalfampridine at room temperature (20–25°C) in a dry place away from moisture and heat. Keep it in its original container, out of reach of children and pets. Do not use expired tablets.
What is the usual dose of Dalfampridine?
The usual dose for adults is 10 mg twice daily, taken approximately 12 hours apart. It should not be crushed, split, or chewed. Doses above 20 mg per day are not recommended due to the risk of seizures. This medication is not approved for children under 18 years.
Warnings and Precautions
Can Dalfampridine be taken safely while breastfeeding?
It is unknown if dalfampridine passes into breast milk. Due to the risk of seizures and neurological effects, breastfeeding while taking this medicine is not recommended.
Can Dalfampridine be taken safely while pregnant?
There is limited data on dalfampridine use in pregnancy. Animal studies suggest potential harm, so it should be used only if the benefits outweigh the risks. Pregnant women should consult their doctor before use.
Can I take Dalfampridine with other prescription drugs?
Dalfampridine should be used cautiously with other seizure-risk drugs (e.g., bupropion, tramadol) and medications affecting kidney function (e.g., NSAIDs). Always consult your doctor before adding new prescriptions.
Is Dalfampridine safe for the elderly?
Elderly patients should use dalfampridine cautiously, especially those with kidney impairment, as they are at higher risk of seizures due to slower drug clearance. Kidney function tests may be required.
Is it safe to drink alcohol while taking Dalfampridine?
Alcohol can increase dizziness, drowsiness, and seizure risk when combined with dalfampridine. If you drink, do so in moderation and observe how your body reacts. Avoid excessive alcohol consumption, as it can worsen side effects and negatively impact MS symptoms.
Is it safe to exercise while taking Dalfampridine?
Yes, exercise is generally safe and can enhance the benefits of dalfampridine by improving mobility and strength in MS patients. However, avoid overexertion, stay hydrated, and take breaks as needed. If you feel dizzy or fatigued, stop and consult your doctor for guidance.
Who should avoid taking Dalfampridine?
People with a history of seizures, moderate to severe kidney disease, or allergy to dalfampridine should avoid it. Patients with mild kidney issues should use it cautiously as it increases seizure risk.
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