Dabigatran etexilate
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Direct Thrombin Inhibitor
Controlled Drug Substance
No
Dabigatran etexilate
Summary
Dabigatran etexilate is used to prevent blood clots in patients with a heart condition called atrial fibrillation and in those who have had clots in their legs or lungs. It's also used to prevent strokes.
Dabigatran etexilate works by inhibiting a substance in your body called thrombin, which plays a key role in blood clotting. It helps to prevent harmful clots from forming in the blood vessels.
The usual dose of Dabigatran etexilate depends on the condition being treated. For preventing stroke in atrial fibrillation and for treating or preventing deep vein thrombosis, it's typically 150 mg taken orally twice daily. Dosage may be adjusted for those with reduced kidney function.
The most common side effects of Dabigatran etexilate include stomach upset or pain. Serious side effects include bleeding, which can be life-threatening.
Dabigatran etexilate can cause serious bleeding. It should not be used if you're having heart valve surgery, if you're allergic to it, or if you're breastfeeding. Pregnant women should use it only if the benefits outweigh the risks.
Indications and Purpose
How does Dabigatran etexilate work?
Dabigatran etexilate is an anticoagulant that works by inhibiting thrombin, which is an enzyme that helps blood to clot. Think of thrombin as a key player in the clotting process, and Dabigatran etexilate as a blocker that prevents it from doing its job. This action helps reduce the risk of blood clots forming in your body, which can lead to conditions like stroke or deep vein thrombosis.
Is Dabigatran etexilate effective?
Dabigatran etexilate is effective in preventing blood clots in conditions like atrial fibrillation and after certain surgeries. Clinical studies show it reduces the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation. It also helps prevent deep vein thrombosis and pulmonary embolism. Always follow your doctor's instructions to ensure the medication works effectively for your condition.
What is Dabigatran etexilate?
Dabigatran etexilate is an anticoagulant, which is a type of medication that helps prevent blood clots. It works by inhibiting thrombin, which is an enzyme involved in blood clotting. This medication is primarily used to reduce the risk of stroke and blood clots in people with atrial fibrillation, which is an irregular heartbeat. It is also used to treat and prevent deep vein thrombosis and pulmonary embolism.
Directions for Use
For how long do I take Dabigatran etexilate?
Dabigatran etexilate is usually a long-term medication for managing conditions like atrial fibrillation. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your conditions to worsen. Always talk with your doctor before changing or stopping your Dabigatran etexilate treatment.
How do I dispose of Dabigatran etexilate?
If you can, bring unused Dabigatran etexilate to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Dabigatran etexilate?
Take Dabigatran etexilate exactly as prescribed by your doctor. It's usually taken twice daily, with or without food. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Dabigatran etexilate to start working?
Dabigatran etexilate begins working in your body shortly after you take it, reaching its highest levels in your blood within a few hours. However, you may not notice all the benefits right away. For conditions like atrial fibrillation, the medication helps prevent blood clots, which may not have immediate observable effects. Always take it exactly as prescribed for the best results.
How should I store Dabigatran etexilate?
Store Dabigatran etexilate at room temperature, away from moisture and light. Keep it in its original packaging to protect it from damage. Don't store it in humid places like bathrooms. Always keep it out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Dabigatran etexilate?
The usual starting dose of Dabigatran etexilate for adults is 150 mg taken twice daily. Your doctor may adjust your dose based on your specific health needs. For certain conditions, like kidney problems, dose adjustments may be necessary. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Dabigatran etexilate be taken safely while breastfeeding?
Dabigatran etexilate is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. While specific reports of harm to breastfed babies are lacking, potential risks can't be ruled out. If you're taking Dabigatran etexilate and want to breastfeed, talk with your doctor about safer medication options.
Can Dabigatran etexilate be taken safely while pregnant?
Dabigatran etexilate isn't recommended during pregnancy due to limited safety data. Animal studies suggest potential risks, but human data is lacking. Uncontrolled blood clotting disorders during pregnancy can cause serious problems for both mother and baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition.
Can I take Dabigatran etexilate with other prescription drugs?
Dabigatran etexilate can interact with other medications, increasing the risk of bleeding. Drugs like aspirin, NSAIDs, and certain blood thinners can enhance this risk. Some medications may also affect how Dabigatran etexilate is processed in the body. Always inform your doctor about all medications you take to prevent interactions and ensure safe treatment.
Does Dabigatran etexilate have adverse effects?
Adverse effects are unwanted reactions to a medication. Dabigatran etexilate can cause bleeding, which is the most common adverse effect. This includes nosebleeds, bleeding gums, or more serious bleeding. If you notice unusual bleeding, contact your doctor immediately. Other side effects may include stomach upset or allergic reactions. Always inform your doctor about any new or worsening symptoms.
Does Dabigatran etexilate have any safety warnings?
Yes, Dabigatran etexilate has important safety warnings. It can increase the risk of bleeding, which can be serious. If you experience unusual bleeding or bruising, seek medical help immediately. This medication may also interact with other drugs, increasing bleeding risk. Always inform your doctor about all medications you take. Follow your doctor's instructions carefully to minimize risks.
Is Dabigatran etexilate addictive?
Dabigatran etexilate is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by affecting blood clotting, not brain chemistry, so it doesn't lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Dabigatran etexilate safe for the elderly?
Elderly individuals are more vulnerable to the safety risks of medications like Dabigatran etexilate due to age-related changes in kidney function and increased bleeding risk. While it is generally safe for the elderly, careful monitoring is essential. Regular check-ups help ensure the medication is working effectively and safely. Always consult your doctor about your specific health needs.
Is it safe to drink alcohol while taking Dabigatran etexilate?
It's best to avoid alcohol while taking Dabigatran etexilate. Alcohol can increase the risk of bleeding, which is a serious side effect of this medication. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like unusual bleeding or bruising. Talk with your doctor about alcohol use while taking Dabigatran etexilate for personalized advice.
Is it safe to exercise while taking Dabigatran etexilate?
You can exercise while taking Dabigatran etexilate, but be cautious. This medication increases the risk of bleeding, so avoid activities with a high risk of injury. If you notice unusual bruising or bleeding during exercise, stop and rest. Most people can maintain their regular exercise routine, but check with your doctor if you have concerns about your specific situation.
Is it safe to stop Dabigatran etexilate?
Stopping Dabigatran etexilate suddenly can increase your risk of blood clots. If you're taking it for conditions like atrial fibrillation, stopping could lead to serious complications like stroke. Always talk with your doctor before stopping Dabigatran etexilate. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
What are the most common side effects of Dabigatran etexilate?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Dabigatran etexilate include stomach upset, indigestion, and bleeding. If you notice new symptoms after starting Dabigatran etexilate, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Dabigatran etexilate?
Don't take Dabigatran etexilate if you have active bleeding or a severe allergy to it. It's not recommended for people with mechanical heart valves. Caution is needed if you have kidney problems, as the drug is cleared by the kidneys. Always consult your doctor about your medical history before starting Dabigatran etexilate.
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