Clopidogrel
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
P2Y12 Platelet Inhibitor
Controlled Drug Substance
NO
Clopidogrel
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Click HereSummary
Clopidogrel is used to treat people with heart or circulation problems such as chest pain, poor circulation in their legs, a heart attack or a stroke. It helps to prevent blood clots from forming in the arteries which can block blood flow and cause serious problems.
Clopidogrel is a medicine that prevents blood clots from forming. It works by stopping platelets in the blood from sticking together and forming clots. This improves blood flow and reduces the likelihood of blockage in blood vessels.
The usual dosage of Clopidogrel for adults is typically 75 mg once daily. It can be taken with or without food and should be swallowed whole with a glass of water. In some cases, higher doses e.g. 300 mg may be used initially especially after a heart attack or stroke.
Clopidogrel can cause side effects like bleeding easier than usual, nosebleeds or bruising. Serious side effects are rare and include things like coughing up blood, blood in urine, stools or vomit, yellowing of the eyes or skin, extreme fatigue or signs of infection like fever or sore throat.
Clopidogrel should be used with caution in people with active bleeding disorders such as peptic ulcer disease or intracranial hemorrhage. It is not recommended for patients with a history of hypersensitivity to Clopidogrel or any of its components, as well as those with severe liver disease. It should also be used cautiously in combination with certain drugs such as proton pump inhibitors or anticoagulants.
Indications and Purpose
What is Clopidogrel used for?
Clopidogrel is used to prevent blood clots in conditions like heart disease and after certain surgeries. It helps reduce the risk of heart attacks and strokes by keeping blood flowing smoothly. It is often used in combination with other treatments.
How does Clopidogrel work?
Clopidogrel works by preventing platelets in the blood from clumping together, which reduces the formation of harmful clots. This action helps prevent heart attacks and strokes by keeping blood flowing smoothly.
Is Clopidogrel effective?
Clopidogrel is primarily used to prevent blood clots in conditions like heart disease. It works by inhibiting platelets, which are cells that help blood clot. Clinical trials have shown that Clopidogrel effectively reduces the risk of heart attacks and strokes.
How does one know if Clopidogrel is working?
Clopidogrel is used to prevent blood clots in conditions like heart disease. Its effectiveness is monitored through clinical indicators like reduced incidence of heart attacks or strokes. Regular check-ups with your healthcare provider can help assess its effectiveness.
Directions for Use
What is the usual dose of Clopidogrel?
The usual starting dose of Clopidogrel for adults is 75 mg once daily. The dose may be adjusted based on individual needs and medical conditions. The maximum recommended dose is typically 75 mg per day. For specific conditions, such as after a heart attack, a higher initial dose may be prescribed. Always follow your healthcare provider's instructions for dosing.
How do I take Clopidogrel?
Take Clopidogrel once daily, with or without food. There are no specific dietary restrictions, but it's important to follow your healthcare provider's instructions. Avoid certain foods or beverages only if advised by your doctor.
For how long do I take Clopidogrel?
Clopidogrel is often used for long-term management of conditions like heart disease. The typical duration depends on the condition being treated, but it can be prescribed for months or even years. Always follow your healthcare provider's instructions regarding the duration of use.
How long does it take for Clopidogrel to start working?
Clopidogrel starts working within a few hours, but it may take several days to achieve its full effect. Individual factors like age and health conditions can affect the onset of action. Always follow your healthcare provider's instructions.
How should I store Clopidogrel?
Store Clopidogrel at room temperature, away from moisture and light. Keep it in a secure place out of reach of children. Avoid storing it in the bathroom or near a sink to prevent exposure to moisture.
How do I dispose of Clopidogrel?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
Warnings and Precautions
Who should avoid taking Clopidogrel?
Absolute contraindications for Clopidogrel include active bleeding and severe liver disease. Relative contraindications include a history of bleeding disorders and recent surgery. These conditions increase the risk of severe bleeding. Always inform your healthcare provider of your medical history before starting Clopidogrel.
Can I take Clopidogrel with other prescription drugs?
Clopidogrel has major interactions with drugs like omeprazole and esomeprazole, which can reduce its effectiveness. It also interacts with anticoagulants, increasing bleeding risk. Always inform your healthcare provider about all medications you are taking to avoid potential interactions.
Can I take Clopidogrel with vitamins or supplements?
Confirmed interactions with Clopidogrel include supplements like St. John's Wort, which can reduce its effectiveness. There is no confirmed need for supplementation due to nutrient depletion by Clopidogrel. Always inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.
Can Clopidogrel be taken safely while pregnant?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Clopidogrel be taken safely while breastfeeding?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Is Clopidogrel safe for the elderly?
Elderly patients may have an increased risk of bleeding when taking Clopidogrel. It is important to monitor for signs of bleeding and consult a healthcare provider for personalized advice. Dose adjustments may be necessary based on individual health conditions.
Is it safe to exercise while taking Clopidogrel?
Most people tolerate Clopidogrel well, and it should not limit your ability to exercise. However, be cautious of any unusual symptoms like dizziness or bleeding during physical activity. Consult your healthcare provider for personalized advice.
Is it safe to drink alcohol while taking Clopidogrel?
Occasional or moderate alcohol consumption is generally not advised while taking Clopidogrel. Alcohol can increase the risk of bleeding, which is a concern with Clopidogrel. Drinking alcohol may also interfere with the medicine's effectiveness. If you choose to drink, limit your intake and monitor for any unusual symptoms. Always consult your healthcare provider for personalized advice.
What are the most common side effects of Clopidogrel?
A side effect is an unwanted symptom caused by medical treatment. Common side effects of Clopidogrel include bleeding, bruising, diarrhea, indigestion, and stomach pain. The frequency of these side effects can vary, but they are generally not experienced by everyone. It's important to note that new symptoms can occur when starting any medication, which may be unrelated or temporary. Always consult a healthcare provider before stopping any medication.
Does Clopidogrel have adverse effects?
Adverse effects are harmful or unintended reactions to a medication. Clopidogrel can cause serious adverse effects like severe bleeding, allergic reactions, liver problems, and low blood cell counts. These effects are rare but require immediate medical attention. Always report new symptoms to your healthcare provider and consult them before stopping the medication.
Is Clopidogrel addictive?
Clopidogrel has no known potential for dependence or addiction. It is not habit-forming, and there are no behaviors or warning signs of physical or psychological dependence associated with its use.
Does Clopidogrel have any safety warnings?
Clopidogrel has safety warnings related to increased risk of bleeding. It is important to monitor for signs of unusual bleeding or bruising. Inform your healthcare provider of any new symptoms and avoid activities that may increase bleeding risk.
Is it safe to stop Clopidogrel?
Clopidogrel is used for long-term management of conditions like heart disease. Stopping it abruptly can increase the risk of heart attack or stroke. There are no known withdrawal symptoms, but the risk of complications is significant. Always consult your doctor before stopping Clopidogrel.
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