Clomipramine
Depressive Disorder, Pain ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Tricyclic Antidepressant
Controlled Drug Substance
NO
Clomipramine
Learn more about this medicine -
Click HereSummary
Clomipramine is used to treat Obsessive-Compulsive Disorder (OCD), a condition that causes unwanted thoughts and repetitive behaviors.
Clomipramine works by increasing the levels of certain chemicals, particularly serotonin and norepinephrine, in the brain. These chemicals play a key role in regulating mood, anxiety, and other emotional responses, helping to reduce OCD symptoms.
Clomipramine is typically taken once daily, usually in the evening or before bedtime. The dosage is started low and slowly increased over two weeks. Adults can take up to a maximum of 250mg a day, while children and teens have a maximum based on their weight, but no more than 200mg a day.
Common side effects of Clomipramine include drowsiness, dizziness, upset stomach, nausea, constipation, and problems with sexual function. It can also cause changes in appetite and weight, and in rare cases, it can cause a drop in sodium levels in the blood.
Clomipramine should not be used by people who are allergic to it or similar medications, or by those taking certain psychiatric medications called MAOIs. It can interact with other drugs and should be used with caution if you have liver or kidney problems. It should not be taken with alcohol, as this can increase side effects. Always consult your doctor before starting this medication.
Indications and Purpose
How does Clomipramine work?
Clomipramine is a tricyclic antidepressant that works by increasing the levels of certain neurotransmitters in the brain, particularly serotonin and norepinephrine. These chemicals play a key role in regulating mood, anxiety, and other emotional responses. By enhancing their activity, clomipramine helps improve symptoms of conditions like depression, obsessive-compulsive disorder (OCD), and anxiety. It may also have mild effects on other brain chemicals, contributing to its therapeutic effects.
How does one know if Clomipramine is working?
You can tell clomipramine is working if you notice improvements in symptoms like reduced anxiety, obsessive thoughts, or compulsive behaviors and improvements in mood. It can take 2 to 4 weeks to start feeling better, and up to 6 to 8 weeks for full effects. Regular follow-ups with your doctor can help assess progress and adjust treatment if needed.
Is Clomipramine effective?
Clomipramine, a medication used to treat moderate to severe OCD (obsessive-compulsive disorder), has been found to be effective in both adults and children and adolescents. Patients taking this medication typically experience a significant reduction in their symptoms, with an average improvement of 35-42% among adults and 37% among children and adolescents.
What is Clomipramine?
Clomipramine is a medication used to treat obsessive-compulsive disorder. It belongs to a group of medicines called tricyclic antidepressants. Clomipramine is available in capsule form and is taken by mouth. It can cause side effects such as drowsiness, dizziness, and seizures. It is important to take clomipramine exactly as prescribed by your doctor.
What is Clomipramine used for?
Clomipramine is a medication used to treat Obsessive-Compulsive Disorder (OCD), a condition that causes unwanted thoughts and repetitive behaviors. It works by increasing the levels of certain chemicals in the brain, which helps to reduce these symptoms.
Directions for Use
For how long do I take Clomipramine?
Clomipramine is typically used as a long-term treatment for chronic conditions such as Obsessive-Compulsive Disorder (OCD). While its effectiveness beyond 10 weeks has not been systematically evaluated in controlled trials, patients have continued therapy for up to one year without losing benefits during clinical studies. For chronic conditions like OCD, the duration of treatment depends on the individual's response and the healthcare provider's assessment, often involving periodic evaluations to determine the need for ongoing therapy
How do I take Clomipramine?
Clomipramine is typically taken once daily, usually in the evening or before bedtime, to minimize daytime drowsiness. It should be swallowed whole with water and can be taken with or without food. Follow your doctor's dosing instructions carefully and do not stop or adjust the dose without consulting your healthcare provider.
How long does it take for Clomipramine to start working?
Clomipramine may take 2 to 4 weeks to start showing noticeable effects, such as improvements in mood or reduced anxiety. However, it can take up to 6 to 8 weeks to experience its full therapeutic benefits. Be patient and continue taking the medication as prescribed, and follow up with your doctor for any concerns or side effects.
How should I store Clomipramine?
Keep this medication at room temperature between 68° to 77°F (20° to 25°C). Store it in a safe place where children cannot reach it. Keep the container tightly closed to protect the medication from moisture.
What is the usual dose of Clomipramine?
Start with a low dose and slowly increase it over two weeks. Adults go up to a maximum of 250mg a day, while children and teens have a maximum based on their weight, but no more than 200mg a day. Once the right dose is found, take it all at once before bed.
Warnings and Precautions
Can Clomipramine be taken safely while breastfeeding?
Clomipramine hydrochloride, a medication, can pass into breast milk. It's important to weigh the benefits of the medication for the mother against the potential risks to the baby. If the medication is essential for the mother's health, she may need to stop breastfeeding. If the medication is not essential, she may be able to continue breastfeeding. However, she should talk to her doctor about the risks and benefits of each option.
Can Clomipramine be taken safely while pregnant?
Clomipramine should only be used during pregnancy if the potential benefits outweigh the potential risks to the baby. Studies in animals have not shown any birth defects, but withdrawal symptoms such as jitteriness, tremors, and seizures have been reported in newborns whose mothers took clomipramine until delivery.
Can I take Clomipramine with other prescription drugs?
Clomipramine is a medication that can interact with other drugs. Some drugs can increase the levels of clomipramine in the body, which can be harmful. These drugs include quinidine, cimetidine, and fluoxetine. Other drugs, such as those that affect the brain or nervous system, should also be used with caution. Clomipramine can also interact with drugs that lower blood pressure. Liver and kidney problems may affect how the body handles clomipramine, but more research is needed.
Can I take Clomipramine with vitamins or supplements?
Clomipramine can be taken with vitamins or supplements, but be cautious with St. John's Wort or supplements that affect serotonin levels. Always consult your doctor before adding any new supplements.
Is Clomipramine safe for the elderly?
For older people, start treatment carefully with low doses. This is because they may have issues with their liver, kidneys, or heart, or they may be taking other medications. They can also be more prone to having low sodium levels in their blood.
Is it safe to drink alcohol while taking Clomipramine?
No, alcohol can increase the sedative effects of Clomipramine and raise the risk of side effects like drowsiness or confusion.
Is it safe to exercise while taking Clomipramine?
Yes, moderate consumption of coffee or tea is generally safe. However, excessive caffeine may worsen anxiety, restlessness, or insomnia.
Who should avoid taking Clomipramine?
Clomipramine hydrochloride capsules should not be used by people who: * Are allergic to clomipramine or other similar medications * Are taking or have recently taken certain medications called MAOIs, which are used to treat psychiatric disorders * Are taking linezolid or intravenous methylene blue, as these medications can increase the risk of a serious condition called serotonin syndrome
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