Clarithromycin

How does Clarithromycin work?

Clarithromycin, an antibiotic, enters body tissues and fluids easily. It builds up more inside cells than in the bloodstream. 

 It binds to the 50S ribosomal subunit of bacteria, preventing the formation of proteins necessary for the bacteria’s growth and survival. Without the ability to produce proteins, the bacteria cannot replicate or repair themselves, leading to their death or inhibition.

Clarithromycin primarily targets Gram-positive bacteria and some Gram-negative bacteria, making it effective in treating respiratory infections, skin infections, and certain types of bacterial stomach infections (like H. pylori). It is often used in combination with other antibiotics for more effective treatment, especially in cases of resistant bacteria.

How does one know if Clarithromycin is working?

Clarithromycin is a powerful antibiotic that has been used effectively to treat infections caused by bacteria. In one study, 88% of patients taking clarithromycin improved or were cured of their infection. This study involved 223 patients. Another study showed that clarithromycin reduced the risk of a type of bloodstream infection called MAC bacteremia by 69% compared to people who took a placebo. Lastly, 88% of patients treated with clarithromycin saw clinical improvement in a third study. These results were similar to patients treated with a cephalosporin, a different type of antibiotic. Overall, the results show that clarithromycin is effective for treating bacterial infections.

Is Clarithromycin effective?

Clarithromycin is a medicine that can help treat infections caused by bacteria. When doctors know what kind of bacteria is causing the infection, they can use that information to decide if Clarithromycin is the right medicine to use. They also consider how often certain types of bacteria cause infections in their area and how well different medicines work against those bacteria when making treatment decisions.

What is Clarithromycin?

Clarithromycin is a medicine that fights bacterial infections. It works by stopping bacteria from making proteins they need to survive. After taking a dose of Clarithromycin, it takes about 3 hours for the medicine to reach its highest level in your body. It spreads into your tissues and fluids, where it can fight the infection. Clarithromycin is not effective against viral infections.

What is Clarithromycin used for?

Clarithromycin is an antibiotic used to treat various infections caused by bacteria. In adults, it's used for chest infections like bronchitis and pneumonia, sinus infections, and throat infections. It also treats skin infections and a type of lung infection in people with advanced HIV. In children, clarithromycin is used for throat infections, pneumonia, sinus infections, ear infections, and skin infections. It's also used to prevent a chest infection in children with advanced HIV.

For how long do I take Clarithromycin?

The typical duration of use for Clarithromycin depends on the type and severity of the infection being treated. Generally:

• For respiratory infections (like pneumonia), the typical duration is 7 to 14 days.
• For skin infections, it is usually around 7 to 10 days.
• For H. pylori eradication in combination with other medications, it may be prescribed for 14 days.

How do I dispose of Clarithromycin?

If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.

How do I take Clarithromycin?

**Clarithromycin Oral Suspension:** * Can be taken with or without food or milk. **Clarithromycin Extended-Release Tablets:** * Must be taken with food. **Other Food Restrictions:** * No other specific food restrictions are mentioned.

How long does it take for Clarithromycin to start working?

Clarithromycin, an antibiotic, starts working quickly, but it's crucial to finish the entire course of treatment for best results. The medicine reaches its maximum levels in your body within a few days or hours, depending on which type you're taking: * Suspension (250 mg every 12 hours): 2-3 days * 1000 mg extended-release tablets: 5-8 hours * 500 mg extended-release tablets: 5-6 hours

How should I store Clarithromycin?

* Don't put the mixed suspension in the fridge. * Keep the mixed suspension at room temperature (between 59° and 86°F) for up to 14 days. * Keep the suspension before mixing it with water below 77°F.

What is the usual dose of Clarithromycin?

For adults, the usual dose of clarithromycin is 500 mg every 12 hours. For children, the recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days, up to the adult dose. Always follow your doctor's specific instructions.

Can Clarithromycin be taken safely while breastfeeding?

A breastfeeding mother taking 250 mg of clarithromycin twice a day passes on a small amount of the drug (136 mcg/kg/day) to her baby through breast milk. This is less than 2% of the dose she takes and less than 1% of the dose recommended for children over 6 months old. A study found that breastfed babies of mothers taking clarithromycin had similar side effects as babies of mothers taking amoxicillin.

Can Clarithromycin be taken safely while pregnant?

If you are pregnant, it is best to avoid taking Clarithromycin unless there are no other treatment options. If you do become pregnant while taking Clarithromycin, talk to your doctor about the potential risks to your unborn baby.

Can I take Clarithromycin with other prescription drugs?

Clarithromycin can interact with certain medications. It can increase the effects of some, like colchicine and disopyramide, which can be life-threatening. It can also increase the risk of muscle problems with some cholesterol-lowering drugs, like simvastatin. Additionally, it can cause dizziness and drowsiness when used with certain sedatives, like triazolam. Always consult your healthcare provider before taking Clarithromycin with other medications.

Can I take Clarithromycin with vitamins or supplements?

Clarithromycin may interact with certain vitamins and supplements. Magnesium or calcium supplements can reduce its effectiveness, so take them separately. Probiotics might lower its efficacy, so it's best to take them a few hours apart. Clarithromycin can also increase the effects of Vitamin K antagonists (e.g., warfarin), raising bleeding risk. Always consult a healthcare provider before using supplements with Clarithromycin.

Does Clarithromycin have adverse effects?

Adverse effects are unwanted or harmful effects caused by a medicine. Clarithromycin can cause nausea, diarrhea, abnormal taste, indigestion, and headache. These are common but usually mild. Rarely, it can cause serious effects like liver problems or severe allergic reactions, which need immediate medical attention. Always report new symptoms to your healthcare provider and consult them before stopping the medicine.

Does Clarithromycin have any safety warnings?

Clarithromycin has safety warnings, including the risk of liver problems, heart rhythm changes, and severe allergic reactions. Liver issues can cause symptoms like yellowing skin or eyes, dark urine, or severe fatigue. Heart rhythm changes might cause dizziness or fainting. Allergic reactions can lead to rash, itching, or swelling. If you notice any of these symptoms, seek medical attention immediately. Always inform your doctor of your medical history and any other medications you're taking.

Is Clarithromycin addictive?

Clarithromycin is not addictive and has no known potential for dependence. It does not cause physical or psychological dependence, so there are no behaviors or warning signs to watch for in terms of addiction. Always use it as prescribed by your healthcare provider to ensure safety and effectiveness.

Is Clarithromycin safe for the elderly?

**For older adults with kidney problems:** * The medication's dosage may need to be adjusted. * They may be more likely to have an irregular heartbeat. * The medication may build up in their blood more than usual. **For older adults taking calcium channel blockers:** * Most reports of kidney problems have been in people 65 or older. **For older adults taking clarithromycin:** * They may be more likely to experience toxic effects from colchicine, especially if they also have kidney problems.

Is it safe to drink alcohol while taking Clarithromycin?

Most people tolerate Clarithromycin well, and occasional alcoholic drinks should not affect the way this medicine works. There are no well-established interactions between Clarithromycin and alcohol that would interfere with the medicine's effectiveness. However, it's always wise to drink alcohol in moderation and consult your healthcare provider if you have any concerns.

Is it safe to exercise while taking Clarithromycin?

Most people tolerate Clarithromycin well, and it should not limit your ability to exercise. There are no known symptoms caused by this medicine that would affect exercise capacity, physical strength, or endurance. However, if you experience any unusual symptoms during physical activity, such as dizziness or fatigue, it's wise to take precautions and consult your healthcare provider.

Is it safe to stop Clarithromycin?

Clarithromycin is typically used to treat temporary or acute conditions like infections. Stopping it abruptly can lead to the infection not being fully treated, which might cause it to return or worsen. There are no withdrawal symptoms, but it's crucial to complete the prescribed course. Always consult your doctor before stopping the medication to avoid complications.

What are the most common side effects of Clarithromycin?

A side effect is an unwanted reaction to a medicine. Common side effects of Clarithromycin include nausea, diarrhea, abnormal taste, indigestion, and headache. These effects are usually mild and temporary. It's important to note that new symptoms can occur when starting any medicine, and they might not be related to the medicine itself. Always talk to your healthcare provider before stopping any medication.

Who should avoid taking Clarithromycin?

**Important Warnings:** * **Allergic reactions:** Clarithromycin can cause severe allergic reactions, such as skin rashes, swelling, and difficulty breathing. Stop taking it and seek immediate medical help if you experience any of these symptoms. * **Heart problems:** Clarithromycin can prolong your heartbeat and increase the risk of arrhythmias (irregular heartbeats). This is especially important if you have existing heart conditions. * **Liver damage:** Clarithromycin can damage your liver, leading to yellowing of the skin or eyes, dark urine, and nausea. If you experience these symptoms, stop taking the medication and consult your doctor. **Medications to Avoid:** Clarithromycin should not be taken with certain other medications, as it can increase their side effects: * Lomitapide, lovastatin, and simvastatin (cholesterol-lowering drugs) * Ergotamine and dihydroergotamine (migraine medications) * Lurasidone (antipsychotic medication) * Colchicine (gout medication), especially if you have kidney or liver problems