Chlorzoxazone
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Muscle Relaxant
Controlled Drug Substance
No
Chlorzoxazone
Summary
Chlorzoxazone is used to relieve pain and stiffness caused by muscle strains and sprains.
Chlorzoxazone works by acting on the spinal cord and brain to inhibit reflex arcs that cause muscle spasms. This results in reduced muscle spasm, pain relief, and increased mobility.
The usual dose of Chlorzoxazone for adults is one tablet (250 mg) three or four times daily. The initial dosage can be two tablets (500 mg) three or four times daily, and if needed, it can be increased to three tablets (750 mg) three or four times daily.
Common side effects of Chlorzoxazone include drowsiness, dizziness, lightheadedness, and upset stomach. Serious adverse effects include liver toxicity which can be fatal.
Chlorzoxazone can cause serious liver toxicity, which may be fatal. It should be discontinued if signs of liver dysfunction appear. It is contraindicated in patients with known intolerance to the drug. Pregnant women should use it only if the benefits outweigh the risks.
Indications and Purpose
How does Chlorzoxazone work?
Chlorzoxazone acts centrally on the spinal cord and subcortical areas of the brain. It inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasms. This action reduces muscle spasms, relieves pain, and increases muscle mobility.
Is Chlorzoxazone effective?
Chlorzoxazone is a centrally-acting agent that helps relieve pain and stiffness caused by muscle strains and sprains. It works by inhibiting reflex arcs in the spinal cord and brain, reducing muscle spasms and increasing mobility. Blood levels of Chlorzoxazone can be detected within 30 minutes, with peak levels reached in 1 to 2 hours after oral administration.
What is Chlorzoxazone?
Chlorzoxazone is used to relieve pain and stiffness from muscle strains and sprains. It works by acting on the spinal cord and brain to inhibit reflex arcs that cause muscle spasms. This results in reduced muscle spasm, pain relief, and increased mobility.
Directions for Use
How do I take Chlorzoxazone?
Chlorzoxazone should be taken exactly as directed by your doctor, usually three or four times a day. There are no specific instructions regarding taking it with or without food, but follow your doctor's advice. There are no known food restrictions, but consult your doctor for personalized guidance.
How long does it take for Chlorzoxazone to start working?
Chlorzoxazone starts working within 30 minutes of oral administration, with peak levels reached in about 1 to 2 hours. This allows for the reduction of muscle spasms and relief of pain.
How should I store Chlorzoxazone?
Store Chlorzoxazone in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program.
What is the usual dose of Chlorzoxazone?
For adults, the usual dose of Chlorzoxazone is one tablet (250 mg) three or four times daily. The initial dosage for painful musculoskeletal conditions can be two tablets (500 mg) three or four times daily. If needed, the dose may be increased to three tablets (750 mg) three or four times daily. As improvement occurs, the dosage can usually be reduced. There is no specific dosage information for children in the provided content. Always follow your doctor's advice for dosing.
Warnings and Precautions
Can Chlorzoxazone be taken safely while pregnant?
The safe use of Chlorzoxazone during pregnancy has not been established. It should be used in women of childbearing potential only when the potential benefits outweigh the possible risks. There is no strong evidence from human studies on fetal harm, but caution is advised.
Can I take Chlorzoxazone with other prescription drugs?
Chlorzoxazone can interact with alcohol and other central nervous system depressants, leading to enhanced side effects like drowsiness and dizziness. It is important to inform your doctor about all medications, supplements, and herbal products you are taking to avoid potential interactions.
Is Chlorzoxazone safe for the elderly?
Older adults should not usually take Chlorzoxazone because it is not as safe or effective as other medications for the same condition. If prescribed, the risks and benefits should be carefully considered by a healthcare professional.
Is it safe to drink alcohol while taking Chlorzoxazone?
Drinking alcohol while taking Chlorzoxazone can worsen the side effects of the medication, such as drowsiness and dizziness. It is advised to ask your doctor about the safe use of alcohol during your treatment with Chlorzoxazone.
Is it safe to exercise while taking Chlorzoxazone?
Chlorzoxazone may cause drowsiness, dizziness, and lightheadedness, which could potentially limit your ability to exercise safely. It is important to understand how the medication affects you before engaging in physical activities. Consult your doctor for personalized advice.
Who should avoid taking Chlorzoxazone?
Chlorzoxazone can cause serious liver toxicity, which may be fatal. It should be discontinued if signs of liver dysfunction appear. Alcohol and other CNS depressants can enhance its side effects. It is contraindicated in patients with known intolerance to the drug. Pregnant women should use it only if the benefits outweigh the risks.
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