Chlordiazepoxide
Anxiety Disorders, Alcohol Withdrawal Delirium
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Benzodiazepine
Controlled Drug Substance
YES
Chlordiazepoxide
Learn more about this medicine -
Click HereSummary
Chlordiazepoxide is used to treat anxiety disorders, withdrawal symptoms from alcohol, and anxiety before surgery.
Chlordiazepoxide works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in your brain. This neurotransmitter reduces nerve cell activity, leading to calming effects, reducing anxiety, inducing sedation, and reducing muscle spasms.
Chlordiazepoxide is taken orally. The starting dose for adults is 50-100 mg per day, which can be adjusted up to 300 mg per day if needed. Once symptoms are under control, the dose is reduced to the lowest effective amount. For elderly or debilitated patients, the starting dose is 10 mg or less per day.
Common side effects include feeling sleepy, having trouble moving, and confusion. In rare cases, it can cause serious problems like passing out, seizures, or even death.
Never take Chlordiazepoxide with opioids as it can lead to serious side effects like slowed breathing, coma, or even death. This medication can be addictive, and stopping suddenly can cause serious withdrawal symptoms which can be life-threatening.
Indications and Purpose
What is Chlordiazepoxide used for?
Chlordiazepoxide is indicated for the management of anxiety disorders and the short-term relief of symptoms of anxiety. It is also used to control agitation caused by alcohol withdrawal and to treat preoperative apprehension and anxiety. Additionally, it may be prescribed for irritable bowel syndrome, although this is not its primary use.
How does Chlordiazepoxide work?
Chlordiazepoxide works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter that helps reduce neuronal excitability, leading to a calming effect on the nervous system. This action helps alleviate symptoms of anxiety and agitation, making it effective for short-term management of these conditions.
Is Chlordiazepoxide effective?
Chlordiazepoxide is a benzodiazepine that has been proven effective in relieving anxiety and controlling agitation caused by alcohol withdrawal. It works by decreasing abnormal electrical activity in the brain. Clinical evidence supports its use for these conditions, although its effectiveness for long-term use has not been systematically assessed. Regular evaluation by a healthcare provider is recommended to ensure its continued benefit.
How does one know if Chlordiazepoxide is working?
The benefit of Chlordiazepoxide is evaluated through regular follow-up appointments with a healthcare provider. During these visits, the provider assesses the effectiveness of the medication in managing symptoms and monitors for any side effects or signs of dependence. Adjustments to the dosage or treatment plan may be made based on the patient's response and overall health condition.
Directions for Use
What is the usual dose of Chlordiazepoxide?
For adults, the usual daily dose of Chlordiazepoxide is 5 mg to 10 mg, taken 3 or 4 times daily. In some cases, the dose may be increased to 20 mg or 25 mg, 3 or 4 times daily, depending on the condition being treated. For children, Chlordiazepoxide is not recommended for use in those under 6 years of age. For older children, the dosage should be carefully adjusted by a healthcare provider.
How do I take Chlordiazepoxide?
Chlordiazepoxide can be taken with or without food, according to personal preference or as directed by a healthcare provider. There are no specific food restrictions associated with this medication. However, it is important to avoid alcohol, as it can increase the risk of serious side effects. Always follow the dosage instructions provided by your healthcare provider.
For how long do I take Chlordiazepoxide?
Chlordiazepoxide is typically prescribed for short-term use, generally not exceeding 4 weeks. This includes the time needed to gradually taper off the medication to avoid withdrawal symptoms. Long-term use is not recommended due to the risk of dependence and other adverse effects. Always follow your healthcare provider's guidance on the duration of use.
How long does it take for Chlordiazepoxide to start working?
Chlordiazepoxide typically begins to work within a few hours after taking a dose. The exact time can vary depending on individual factors such as metabolism and the specific condition being treated. For anxiety relief, patients may notice a calming effect relatively quickly, but it may take longer to see the full benefits for conditions like alcohol withdrawal.
How should I store Chlordiazepoxide?
Chlordiazepoxide should be stored in its original container, tightly closed, and kept out of reach of children. It should be stored at room temperature, away from excess heat and moisture, and not in the bathroom. Unneeded medication should be disposed of properly, preferably through a medicine take-back program, to prevent accidental ingestion by children or pets.
Warnings and Precautions
Who should avoid taking Chlordiazepoxide?
Chlordiazepoxide carries important warnings, including the risk of serious breathing problems, sedation, or coma when used with opioids. It can be habit-forming and should not be used with alcohol or street drugs. It is contraindicated in patients with known hypersensitivity to the drug, severe liver disease, and certain psychiatric conditions. Abrupt discontinuation can lead to withdrawal symptoms, so dosage should be tapered gradually under medical supervision.
Can I take Chlordiazepoxide with other prescription drugs?
Chlordiazepoxide can interact with several prescription drugs, leading to increased sedation and respiratory depression. Notable interactions include opioids, other benzodiazepines, and CNS depressants. It can also interact with medications that affect liver enzymes, such as cimetidine, which may enhance its effects. Patients should inform their healthcare provider of all medications they are taking to avoid harmful interactions.
Can I take Chlordiazepoxide with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Chlordiazepoxide be taken safely while pregnant?
Chlordiazepoxide is not recommended during pregnancy, especially in the first and last trimesters, unless absolutely necessary. It can cause sedation and withdrawal symptoms in newborns. While some studies have suggested an increased risk of congenital malformations, the evidence is not consistent. Pregnant women should consult their healthcare provider to weigh the risks and benefits before using this medication.
Can Chlordiazepoxide be taken safely while breastfeeding?
Breastfeeding is not recommended during treatment with Chlordiazepoxide. The medication can pass into breast milk and may cause sedation, poor feeding, and withdrawal symptoms in infants. Mothers should discuss alternative treatments with their healthcare provider to ensure the safety of their child while managing their own health needs.
Is Chlordiazepoxide safe for the elderly?
For elderly patients, Chlordiazepoxide should be used with caution. The dosage should be limited to the smallest effective amount to avoid oversedation or ataxia. Elderly individuals are more sensitive to the effects of this medication, and there is an increased risk of falls and cognitive impairment. Regular monitoring and dosage adjustments may be necessary to ensure safety.
Is it safe to exercise while taking Chlordiazepoxide?
Chlordiazepoxide can cause drowsiness, dizziness, and fatigue, which may limit your ability to exercise safely. It is important to understand how the medication affects you before engaging in physical activities. If you feel too drowsy or dizzy, it is best to avoid exercise until you have consulted with your healthcare provider for advice.
Is it safe to drink alcohol while taking Chlordiazepoxide?
Drinking alcohol while taking Chlordiazepoxide can significantly increase the risk of serious side effects, including severe drowsiness, breathing problems, and even coma. Alcohol can enhance the sedative effects of Chlordiazepoxide, making it unsafe to consume alcohol in any amount during treatment. It is crucial to avoid alcohol to ensure the safe and effective use of this medication.
Forms / Brands
