Cabozantinib
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Summary
Cabozantinib is used to treat certain types of cancer, such as kidney and thyroid cancer. It is often prescribed when other treatments haven't worked or when the cancer has spread. This medication can be used alone or in combination with other therapies to help manage the disease.
Cabozantinib works by blocking proteins called tyrosine kinases, which are signals that cancer cells need to grow and spread. By turning off these signals, the medication helps slow or stop the progression of cancer, improving treatment outcomes for patients.
The usual starting dose of Cabozantinib for adults is 60 mg taken once daily. It should be taken on an empty stomach, at least 1 hour before or 2 hours after eating. The tablets should not be crushed or chewed, and the dose may be adjusted by a doctor based on response and side effects.
Common side effects of Cabozantinib include diarrhea, fatigue, and decreased appetite. These effects occur in more than 10% of patients and are usually mild to moderate. If you experience any new or worsening symptoms, it is important to contact your doctor immediately for advice.
Cabozantinib has important safety warnings, including the risk of severe bleeding, perforations, and fistulas, which are abnormal connections between organs. It is not recommended for use during pregnancy or breastfeeding. Patients should avoid grapefruit and certain supplements that may interact with the medication.
Indications and Purpose
How does Cabozantinib work?
Cabozantinib works by blocking certain proteins called tyrosine kinases, which help cancer cells grow and spread. Think of it like turning off a switch that powers cancer cell growth. This helps slow or stop the progression of cancer, improving treatment outcomes.
Is Cabozantinib effective?
Cabozantinib is effective in treating certain types of cancer, such as kidney and thyroid cancer. Clinical studies show it can slow disease progression and improve survival rates. Your doctor will monitor your response to ensure the medication is working effectively for you.
What is Cabozantinib?
Cabozantinib is a medication used to treat certain types of cancer, such as kidney and thyroid cancer. It belongs to a class of drugs called tyrosine kinase inhibitors, which block signals that cancer cells need to grow. This helps slow or stop the growth of cancer.
Directions for Use
For how long do I take Cabozantinib?
Cabozantinib is usually taken long-term for cancer treatment. The duration depends on your response and any side effects. Your doctor will monitor your progress and adjust your treatment as needed. Always follow your doctor's advice on how long to take Cabozantinib.
How do I dispose of Cabozantinib?
Dispose of unused Cabozantinib through a drug take-back program at a pharmacy or hospital. If unavailable, mix the medication with undesirable substances like used coffee grounds, seal in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take Cabozantinib?
Take Cabozantinib exactly as your doctor prescribes. Usually, it's taken once daily on an empty stomach, at least 1 hour before or 2 hours after eating. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Avoid grapefruit and grapefruit juice while taking this medication.
How long does it take for Cabozantinib to start working?
Cabozantinib starts working in your body shortly after you take it, but noticeable effects may take weeks. The full therapeutic effect can take several months. How quickly it works depends on your overall health and cancer type. Follow your doctor's instructions for the best results.
How should I store Cabozantinib?
Store Cabozantinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in the bathroom, where humidity can affect the medication. Keep it out of reach of children to prevent accidental ingestion.
What is the usual dose of Cabozantinib?
The usual starting dose of Cabozantinib for adults is 60 mg once daily. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 60 mg daily. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can Cabozantinib be taken safely while breastfeeding?
Cabozantinib is not recommended while breastfeeding. It's unclear if it passes into breast milk, but it may pose risks to a nursing infant. Discuss safer medication options with your doctor if you wish to breastfeed while on treatment.
Can Cabozantinib be taken safely while pregnant?
Cabozantinib is not recommended during pregnancy. It can harm an unborn baby. Limited human data is available, but animal studies show potential risks. If you're pregnant or planning to become pregnant, discuss safer treatment options with your doctor.
Can I take Cabozantinib with other prescription drugs?
Cabozantinib can interact with certain drugs, increasing the risk of side effects. Strong CYP3A4 inhibitors like ketoconazole can increase Cabozantinib levels, while inducers like rifampin can decrease its effectiveness. Always inform your doctor about all medications you take to avoid interactions.
Does Cabozantinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Cabozantinib include diarrhea, fatigue, and decreased appetite. Serious effects can include severe bleeding and liver problems. If you notice any new or worsening symptoms, contact your doctor immediately.
Does Cabozantinib have any safety warnings?
Yes, Cabozantinib has important safety warnings. It can cause severe bleeding, perforations, and fistulas, which are abnormal connections between organs. These conditions require immediate medical attention. Not following safety warnings can lead to serious health risks. Always discuss any concerns with your doctor.
Is Cabozantinib addictive?
Cabozantinib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms. This medication works by targeting cancer cells and does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings or feel compelled to take more than prescribed.
Is it safe to drink alcohol while taking Cabozantinib?
It's best to avoid alcohol while taking Cabozantinib. Alcohol can increase the risk of liver damage and worsen side effects like dizziness. If you choose to drink, limit your intake and watch for warning signs. Discuss alcohol use with your doctor for personalized advice.
Is it safe to exercise while taking Cabozantinib?
You can exercise while taking Cabozantinib, but be cautious. The medication can cause fatigue and dizziness, which may affect your exercise capacity. Stay hydrated and avoid strenuous activities if you feel unwell. Consult your doctor if you have concerns about exercising.
Is it safe to stop Cabozantinib?
Stopping Cabozantinib suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice can worsen your condition. Always talk with your doctor before stopping. They may suggest a gradual reduction or alternative treatment.
What are the most common side effects of Cabozantinib?
Side effects are unwanted reactions to a medication. Common side effects of Cabozantinib include diarrhea, fatigue, and decreased appetite. These occur in more than 10% of patients. If you experience new symptoms, they might be temporary or unrelated to the medication. Consult your doctor before stopping any medication.
Who should avoid taking Cabozantinib?
Do not use Cabozantinib if you have severe bleeding or recent surgery. These are absolute contraindications due to severe risks. Use caution if you have liver problems or high blood pressure. Always discuss your medical history with your doctor before starting Cabozantinib.
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