Busulfan
BCR-ABL Positive Chronic Myelogenous Leukemia, Polycythemia Vera ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Alkylating Drug
Controlled Drug Substance
NO
Busulfan
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Click HereSummary
Busulfan is primarily used to treat a type of blood cancer called chronic myelogenous leukemia (CML). It is also used in combination with other drugs to prepare patients for bone marrow transplantation.
Busulfan works by binding to DNA in cancer cells and interfering with their replication, which slows or stops their growth. This is particularly effective in reducing a type of white blood cells in CML.
Busulfan is usually taken orally once a day. The dose for adults typically ranges from 4 to 8 mg per day. For children, the dose is usually based on their body weight or surface area.
Common side effects of Busulfan include nausea, diarrhea, loss of appetite, and dizziness. Serious adverse effects include severe bone marrow suppression, pulmonary fibrosis, and increased risk of secondary cancers.
Busulfan may harm the fetus and is not recommended during pregnancy. It can also cause severe bone marrow suppression and may increase the risk of other cancers. Patients with a history of hypersensitivity to Busulfan should not use it.
Indications and Purpose
What is Busulfan used for?
Busulfan is primarily used to treat chronic myelogenous leukemia (CML), a type of cancer affecting white blood cells. It is also used in combination with other drugs to prepare patients for bone marrow transplantation by destroying bone marrow and cancer cells.
How does Busulfan work?
Busulfan is an alkylating agent that works by damaging the DNA of cancer cells, which slows or stops their growth and multiplication. This action helps reduce the number of cancerous white blood cells in the body.
Is Busulfan effective?
Busulfan is effective in treating chronic myelogenous leukemia (CML) by reducing the total granulocyte mass, relieving symptoms, and improving the clinical state of patients. Approximately 90% of adults with previously untreated CML achieve hematologic remission with Busulfan.
How does one know if Busulfan is working?
The benefit of Busulfan is evaluated through regular blood tests to monitor blood cell counts and assess the body's response to the medication. Your doctor will adjust the dose or pause treatment based on these results to ensure safety and effectiveness.
Directions for Use
What is the usual dose of Busulfan?
The usual adult dose range for Busulfan is 4 to 8 mg daily. For children, the dosing is based on body weight, approximately 60 mcg/kg of body weight or 1.8 mg/m² of body surface area daily. Always follow your doctor's specific instructions for dosing.
How do I take Busulfan?
Busulfan should be taken exactly as prescribed by your doctor, usually once a day at the same time each day. There are no specific food restrictions mentioned, but it's important to follow your doctor's instructions regarding food intake.
For how long do I take Busulfan?
The duration of Busulfan treatment depends on the type of cancer being treated and the patient's response to the medication. It can range from several weeks to months. Your doctor will determine the appropriate length of treatment based on your specific condition.
How long does it take for Busulfan to start working?
Busulfan's effects on blood cell counts may not be seen during the first 10 to 15 days of treatment. The leukocyte count may continue to fall for more than a month after discontinuing the drug, indicating its ongoing effect.
How should I store Busulfan?
Store Busulfan in its original container, tightly closed, at room temperature, away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program, not by flushing it down the toilet.
Warnings and Precautions
Who should avoid taking Busulfan?
Busulfan can cause severe bone marrow suppression, leading to low blood cell counts. It may also increase the risk of developing other cancers. Patients should be monitored closely for signs of infection, unusual bleeding, or bruising. Busulfan is contraindicated in patients with hypersensitivity to the drug or its components.
Can I take Busulfan with other prescription drugs?
Busulfan may interact with medications like acetaminophen, itraconazole, and cyclophosphamide, affecting its clearance and increasing toxicity. Inform your doctor about all medications you are taking to avoid potential interactions and ensure safe use of Busulfan.
Can I take Busulfan with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Busulfan be taken safely while pregnant?
Busulfan may harm the fetus and should not be used during pregnancy. Women of childbearing potential should use reliable birth control and avoid becoming pregnant while on Busulfan. If pregnancy occurs, contact your doctor immediately. There is evidence of potential fetal harm from animal studies.
Can Busulfan be taken safely while breastfeeding?
It is not known whether Busulfan is excreted in human milk. Due to the potential for tumorigenicity, a decision should be made to either discontinue nursing or discontinue the drug, considering the importance of the drug to the mother.
Is Busulfan safe for the elderly?
For elderly patients, Busulfan should be used with caution, typically starting at the lower end of the dosing range. This is due to the increased likelihood of decreased liver, kidney, or heart function, and the presence of other medical conditions or treatments. Regular monitoring and dose adjustments may be necessary.
Is it safe to exercise while taking Busulfan?
Busulfan may cause fatigue, weakness, or other side effects that could limit your ability to exercise. If you experience these symptoms, it's important to discuss them with your doctor, who can provide guidance on safe levels of physical activity.
Is it safe to drink alcohol while taking Busulfan?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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