Bumetanide
Hypertension, Chronic Kidney Failure ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Loop Diuretic
Controlled Drug Substance
NO
Bumetanide
Learn more about this medicine -
Click HereSummary
Bumetanide is used to treat fluid retention, also known as edema, caused by conditions like heart failure, liver disease, and kidney disorders. It can also be used for high blood pressure in some cases.
Bumetanide works by increasing the excretion of sodium, potassium, and water through the kidneys. This helps to reduce excess fluid buildup in the body, lowering swelling and blood pressure, and improving circulation and breathing.
The typical oral dose for adults is 0.5 mg to 2 mg once daily, with a maximum of 10 mg per day. In severe cases, doses may be divided throughout the day. Always follow a doctor's prescription for safe dosing.
Common side effects include dizziness, dehydration, low blood pressure, muscle cramps, and low potassium levels. Serious risks include electrolyte imbalances, kidney damage, or hearing loss at high doses.
People with severe kidney failure, dehydration, electrolyte imbalance, or sulfa allergy should avoid Bumetanide. It should also be used with caution in elderly patients, pregnant women, and those with low blood pressure. Always consult your doctor before use.
Indications and Purpose
What is Bumetanide used for?
Bumetanide treats edema (fluid retention) caused by heart failure, liver cirrhosis, or kidney disease. It helps reduce swelling in the legs, lungs, and abdomen, making it easier to breathe and move. It is also used for high blood pressure (hypertension) in some cases.
How does Bumetanide work?
Bumetanide blocks sodium and chloride reabsorption in the kidneys’ loop of Henle, causing more urine output. This helps reduce fluid overload, lowering blood pressure and swelling. Unlike thiazide diuretics, it works even in severe kidney disease.
Is Bumetanide effective?
Yes, studies show bumetanide effectively reduces edema and improves symptoms of heart failure, liver disease, and kidney conditions. It is often preferred over furosemide due to stronger diuretic action and better absorption. However, effectiveness depends on proper dosing and diet control.
How does one know if Bumetanide is working?
You may notice reduced swelling in your legs, ankles, or abdomen, easier breathing, and increased urine output. Doctors monitor weight, blood pressure, and kidney function tests to ensure effectiveness. If swelling persists, the dose may need adjustment.
Directions for Use
What is the usual dose of Bumetanide?
For adults, the typical oral dose is 0.5 mg to 2 mg once daily, with a maximum of 10 mg per day. In severe cases, doses may be divided throughout the day. Children are rarely prescribed bumetanide, but if used, the dose is based on weight. Always follow a doctor’s prescription for safe dosing.
How do I take Bumetanide?
Take bumetanide once daily, preferably in the morning, to avoid nighttime urination. It can be taken with or without food, but drinking plenty of water is essential. Avoid high-sodium foods, as they can reduce the drug’s effectiveness. Follow your doctor's advice on potassium supplements if needed.
For how long do I take Bumetanide?
The duration depends on the condition being treated. For chronic diseases like heart failure or kidney disease, bumetanide is often taken long-term. If used for short-term fluid retention, treatment may last a few days to weeks. Never stop abruptly without a doctor’s advice.
How long does it take for Bumetanide to start working?
Bumetanide starts working within 30 to 60 minutes after taking it orally. Its effects peak in 1 to 2 hours and last about 4 to 6 hours. It works quickly to remove excess fluid, leading to increased urination.
How should I store Bumetanide?
Store bumetanide at room temperature (20-25°C) in a dry place, away from moisture and direct sunlight. Keep it out of reach of children. Do not use expired tablets.
Warnings and Precautions
Who should avoid taking Bumetanide?
People with severe kidney failure, dehydration, electrolyte imbalance, or sulfa allergy should avoid bumetanide. It should also be used with caution in elderly patients, pregnant women, and those with low blood pressure.
Can I take Bumetanide with other prescription drugs?
Bumetanide interacts with blood pressure medications, lithium, NSAIDs, and corticosteroids. Combining it with digoxin increases the risk of heart rhythm problems. If taking multiple medications, regular monitoring is needed.
Can I take Bumetanide with vitamins or supplements?
Yes, but electrolyte supplements (potassium, magnesium) may be needed to prevent imbalances. Avoid excessive calcium supplements, as they can cause kidney stones. Always consult a doctor before taking new supplements.
Can Bumetanide be taken safely while pregnant?
Bumetanide is classified as pregnancy category C, meaning risk cannot be ruled out. It should only be used if benefits outweigh risks, as it may cause fetal electrolyte imbalances. Always consult your doctor before use.
Can Bumetanide be taken safely while breastfeeding?
Bumetanide passes into breast milk, potentially affecting the baby’s fluid balance. It is not recommended during breastfeeding unless prescribed by a doctor. If necessary, formula feeding may be advised.
Is Bumetanide safe for the elderly?
Elderly patients have a higher risk of dehydration, dizziness, and kidney issues with bumetanide. Lower doses and frequent monitoring of electrolytes and kidney function are recommended to avoid complications.
Is it safe to exercise while taking Bumetanide?
Yes, but intense exercise can lead to excessive dehydration and electrolyte loss. Drink enough fluids and avoid extreme workouts.
Is it safe to drink alcohol while taking Bumetanide?
No, alcohol increases dizziness and dehydration, making side effects worse. Avoid drinking while on bumetanide.