Brigatinib
Non-Small-Cell Lung Carcinoma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Brigatinib
Summary
Brigatinib is used to treat a type of lung cancer called anaplastic lymphoma kinase (ALK) positive metastatic non-small cell lung cancer (NSCLC). This means it's used when the cancer has spread to other parts of the body.
Brigatinib works by targeting and blocking the activity of an abnormal protein called ALK that signals cancer cells to multiply. By inhibiting this protein, Brigatinib helps to slow or stop the growth and spread of cancer cells in the body.
Brigatinib is typically prescribed for adults with a starting dose of 90 mg once daily for the first 7 days. If this is well-tolerated, the dose is increased to 180 mg once daily. It's taken orally, and you should swallow the tablets whole without crushing or chewing them.
Common side effects of Brigatinib include nausea, diarrhea, fatigue, headache, and rash. Serious adverse effects can include lung disease, high blood pressure, slow heart rate, and liver damage.
Brigatinib shouldn't be used if you're allergic to it or its components. It can cause harm to a fetus, so effective contraception should be used during treatment and for at least 4 months after the final dose. It's also advised not to breastfeed during treatment and for at least 1 week after the final dose.
Indications and Purpose
How does Brigatinib work?
Brigatinib works by blocking a protein called ALK, which helps cancer cells grow. Think of it like turning off a switch that powers cancer cell growth. By inhibiting this protein, Brigatinib slows or stops the growth of cancer cells. This action makes it effective for treating ALK-positive non-small cell lung cancer, helping to shrink tumors and slow disease progression.
Is Brigatinib effective?
Brigatinib is effective in treating certain types of lung cancer. It works by blocking specific proteins that help cancer cells grow. Clinical studies show Brigatinib can shrink tumors and slow cancer progression. It is particularly effective in patients with ALK-positive non-small cell lung cancer. Your doctor will monitor your response to the medication through regular check-ups and tests to ensure it's working effectively for you.
What is Brigatinib?
Brigatinib is a medication used to treat certain types of lung cancer. It belongs to a class of drugs called ALK inhibitors, which block proteins that help cancer cells grow. Brigatinib is primarily used for ALK-positive non-small cell lung cancer. It can be used alone or with other therapies to manage cancer and improve patient outcomes.
Directions for Use
For how long do I take Brigatinib?
Brigatinib is usually a long-term medication for managing certain types of lung cancer. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your treatment.
How do I dispose of Brigatinib?
Dispose of unused Brigatinib through a drug take-back program or collection site at a pharmacy or hospital. This ensures the medication is disposed of properly and doesn't harm people or the environment. If you can't find a take-back program, you can throw it in the trash at home. Mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take Brigatinib?
Brigatinib is usually taken once daily. You can take it with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions regarding diet and fluid intake while on this medication.
How long does it take for Brigatinib to start working?
Brigatinib starts working in your body shortly after you take it, but the full therapeutic effect may take weeks to months. The time it takes to see benefits can vary based on individual factors like your overall health and cancer stage. Regular check-ups and tests with your doctor will help monitor your progress and determine how well Brigatinib is working for you.
How should I store Brigatinib?
Store Brigatinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Brigatinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Brigatinib?
The usual starting dose of Brigatinib for adults is 90 mg once daily for the first seven days. After this, the dose is typically increased to 180 mg once daily. Always follow your doctor's specific dosing instructions. Dose adjustments may be necessary for certain populations, such as the elderly or those with specific health conditions. Your doctor will guide you on the appropriate dose for your health needs.
Warnings and Precautions
Can Brigatinib be taken safely while breastfeeding?
Brigatinib is not recommended while breastfeeding. It's unclear if it passes into human breast milk, but it could pose risks to a nursing infant. The medication might affect a baby's developing organs. If you're taking Brigatinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Brigatinib be taken safely while pregnant?
Brigatinib is not recommended during pregnancy. It may harm an unborn baby. There is limited information on its use in pregnant women, but animal studies suggest potential risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a plan that protects both you and your baby.
Can I take Brigatinib with other prescription drugs?
Brigatinib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Avoid using it with strong CYP3A inhibitors, which are drugs that affect liver enzymes, as they can increase Brigatinib levels in your body. Always inform your doctor about all medications you take to prevent interactions. Your doctor can adjust your treatment plan to ensure safety and effectiveness.
Does Brigatinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Brigatinib include nausea, diarrhea, and fatigue. Serious side effects can include lung problems, high blood pressure, and slow heart rate. If you experience severe symptoms, seek medical attention immediately. Always inform your doctor about any new or worsening symptoms while taking Brigatinib to ensure your treatment is safe and effective.
Does Brigatinib have any safety warnings?
Yes, Brigatinib has important safety warnings. It can cause serious lung problems, high blood pressure, and slow heart rate. If you experience symptoms like difficulty breathing, chest pain, or dizziness, seek medical help immediately. Brigatinib can also cause vision problems and muscle pain. Regular monitoring by your doctor is important to manage these risks. Always adhere to your doctor's advice and report any new or worsening symptoms.
Is Brigatinib addictive?
Brigatinib is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Brigatinib works by targeting specific proteins in cancer cells, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Brigatinib doesn't carry this risk.
Is Brigatinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Brigatinib, such as high blood pressure and lung problems. Regular monitoring by a doctor is important to manage these risks. Brigatinib can be used safely in the elderly with careful supervision. Always discuss any concerns with your doctor to ensure the medication is appropriate for your health needs.
Is it safe to drink alcohol while taking Brigatinib?
It's best to avoid alcohol while taking Brigatinib. Alcohol can increase the risk of side effects like dizziness or low blood pressure. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Brigatinib to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Brigatinib?
You can exercise while taking Brigatinib, but be cautious. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, drink plenty of water and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Check with your doctor if you have concerns about your specific situation.
Is it safe to stop Brigatinib?
Stopping Brigatinib suddenly can cause your condition to worsen. It's used for long-term treatment of certain cancers. If you stop taking it without medical advice, the cancer may progress. Always talk with your doctor before stopping Brigatinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of Brigatinib?
Side effects are unwanted reactions to a medication. Common side effects of Brigatinib include nausea, diarrhea, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Brigatinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. Your doctor can help determine if the symptoms are related to Brigatinib or another cause.
Who should avoid taking Brigatinib?
Brigatinib should not be used if you are allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Caution is needed if you have lung problems, high blood pressure, or a slow heart rate. Brigatinib may worsen these conditions. Always consult your doctor about your medical history before starting Brigatinib to ensure it's safe for you.
