Binimetinib
Melanoma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
None
Controlled Drug Substance
No
Binimetinib
Summary
Binimetinib is used to treat certain types of melanoma and non-small cell lung cancer that have spread or cannot be removed by surgery. Specifically, it's used for melanoma with a BRAF V600E or V600K mutation and non-small cell lung cancer with a BRAF V600E mutation.
Binimetinib works by blocking the action of abnormal proteins that signal cancer cells to multiply. This helps to stop or slow the spread of cancer cells in the body.
The usual daily dose for adults is 45 mg, taken orally twice daily, approximately 12 hours apart. It can be taken with or without food.
Common side effects of Binimetinib include fatigue, nausea, diarrhea, vomiting, and abdominal pain. Serious side effects can include vision changes, heart problems, and liver issues.
Binimetinib may cause new primary malignancies, cardiomyopathy, venous thromboembolism, ocular toxicities, interstitial lung disease, hepatotoxicity, rhabdomyolysis, and hemorrhage. It is contraindicated in patients with a history of retinal vein occlusion.
Indications and Purpose
How does Binimetinib work?
Binimetinib is a kinase inhibitor that works by blocking the action of abnormal proteins that signal cancer cells to multiply. By inhibiting these proteins, Binimetinib helps to stop or slow the spread of cancer cells, making it effective in treating certain types of melanoma and non-small cell lung cancer.
Is Binimetinib effective?
Binimetinib, in combination with encorafenib, has been shown to improve progression-free survival in patients with BRAF V600 mutation-positive unresectable or metastatic melanoma. Clinical trials demonstrated a statistically significant improvement in progression-free survival compared to vemurafenib alone, supporting its effectiveness in treating this type of cancer.
What is Binimetinib?
Binimetinib is used in combination with encorafenib to treat certain types of melanoma and non-small cell lung cancer that have spread or cannot be removed by surgery. It belongs to a class of medications called kinase inhibitors, which work by blocking the action of abnormal proteins that signal cancer cells to multiply, helping to stop or slow the spread of cancer cells.
Directions for Use
For how long do I take Binimetinib?
Binimetinib is typically used until disease progression or unacceptable toxicity occurs. The duration of use can vary based on individual response and tolerance to the medication. Always follow your doctor's guidance regarding the length of treatment.
How do I dispose of Binimetinib?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Binimetinib?
Binimetinib should be taken orally twice daily, approximately 12 hours apart, and can be taken with or without food. There are no specific food restrictions mentioned, but it is important to take the medication at the same times each day for consistency. Always follow your doctor's instructions regarding dosage and administration.
How long does it take for Binimetinib to start working?
Binimetinib starts working within a few hours, reaching peak levels in the blood in about 1 to 1.5 hours. The full therapeutic effect may take several weeks to become apparent, as it depends on individual response and the specific condition being treated. Factors like overall health and other medications can affect how quickly it works. Always follow your healthcare provider's instructions to ensure the best results from your treatment.
How should I store Binimetinib?
Binimetinib should be stored at room temperature, between 68°F to 77°F (20°C to 25°C). It should be kept in its original container, tightly closed, and out of reach of children. Avoid storing it in the bathroom or areas with excess heat and moisture. Proper storage ensures the medication remains effective and safe to use.
What is the usual dose of Binimetinib?
The usual daily dose for adults taking Binimetinib is 45 mg taken orally twice daily, approximately 12 hours apart. There is no established dose for children as the safety and effectiveness of Binimetinib have not been established in pediatric patients. Always follow your doctor's advice for dosing.
Warnings and Precautions
Can Binimetinib be taken safely while breastfeeding?
Women are advised not to breastfeed while taking Binimetinib and for 3 days after the last dose due to the potential for serious adverse reactions in a breastfed child. It is important to discuss with your healthcare provider the best way to feed your baby during this time.
Can Binimetinib be taken safely while pregnant?
Binimetinib can cause fetal harm when administered to a pregnant woman. Females of reproductive potential should use effective contraception during treatment and for 30 days after the last dose. A pregnancy test is required before starting treatment. If you become pregnant while taking Binimetinib, contact your doctor immediately.
Can I take Binimetinib with other prescription drugs?
No clinically important drug interactions have been observed with Binimetinib. However, it is always important to inform your healthcare provider about all medications you are taking, including prescription, over-the-counter, and herbal supplements, to ensure there are no potential interactions.
Does Binimetinib have adverse effects?
Adverse effects are unwanted or harmful effects caused by a medicine. Binimetinib can cause several adverse effects. Common ones include fatigue, nausea, and diarrhea. Serious but rare effects might include heart problems, eye issues, or liver damage. If you experience symptoms like chest pain, vision changes, or yellowing of the skin, seek medical help immediately. Always report new symptoms to your healthcare provider and never stop taking the medicine without their guidance.
Does Binimetinib have any safety warnings?
Binimetinib comes with several safety warnings. It can affect heart function, so watch for symptoms like chest pain or shortness of breath. Eye problems are possible, so report any vision changes. Liver issues might occur, so look out for yellowing of the skin or eyes. Skin reactions can happen, so notify your doctor if you notice any severe rashes. Regular monitoring by your healthcare provider is crucial to catch any issues early and adjust treatment as needed.
Is Binimetinib addictive?
Binimetinib is not known to be addictive. It does not have habit-forming potential, and there are no known physical or psychological dependence issues associated with its use. Therefore, there are no specific behaviors or warning signs to watch for regarding addiction. It's important to use Binimetinib as prescribed by your healthcare provider and to discuss any concerns you may have about your treatment.
Is Binimetinib safe for the elderly?
No overall differences in the safety or effectiveness of Binimetinib were observed in older patients compared to younger patients. However, elderly patients may be more susceptible to certain side effects, such as diarrhea and pruritus. It is important for elderly patients to be closely monitored by their healthcare provider while taking Binimetinib.
Is it safe to drink alcohol while taking Binimetinib?
Most people tolerate Binimetinib well, and occasional alcoholic drinks should not affect the way this medicine works. There are no well-established interactions between Binimetinib and alcohol that would interfere with its effectiveness. However, alcohol can affect your overall health, so it's wise to consume it in moderation. Always discuss with your healthcare provider to ensure that alcohol consumption is safe for your specific health situation while on this medication.
Is it safe to exercise while taking Binimetinib?
Binimetinib may cause fatigue and muscle pain, which could limit the ability to exercise. If you experience these symptoms, it is important to discuss them with your doctor. They can provide guidance on managing side effects and advise on safe levels of physical activity.
Is it safe to stop Binimetinib?
Binimetinib is typically used for managing certain types of cancer, which requires ongoing treatment. Stopping it suddenly without consulting a doctor can lead to the cancer progressing or worsening. There are no known withdrawal symptoms, but the risk of the disease returning or getting worse is significant. It's crucial to talk to your healthcare provider before making any changes to your medication regimen to ensure it's safe and appropriate for your condition.
What are the most common side effects of Binimetinib?
A side effect is an unwanted reaction to a medicine. Common side effects of Binimetinib include fatigue, nausea, diarrhea, vomiting, and skin rash. These effects are frequently reported. It's important to note that new symptoms can occur when starting any new medicine, and they might not be related to the medicine itself. Always talk to your healthcare provider before stopping any medication to ensure it's safe and appropriate for your situation.
Who should avoid taking Binimetinib?
Important warnings for Binimetinib include the risk of new primary malignancies, cardiomyopathy, venous thromboembolism, ocular toxicities, interstitial lung disease, hepatotoxicity, rhabdomyolysis, and hemorrhage. Patients should be monitored for these conditions, and the medication should be used with caution in those with pre-existing conditions that may increase these risks. It is contraindicated in patients with a history of retinal vein occlusion.
