Axitinib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Axitinib
Summary
Axitinib is used to treat advanced renal cell carcinoma, which is a type of kidney cancer. It is typically prescribed when other treatments have not been effective or are no longer working.
Axitinib works by inhibiting tyrosine kinases, which are proteins that help cancer cells grow and spread. By blocking these proteins, it slows the progression of cancer and can shrink tumors.
The usual starting dose of Axitinib for adults is 5 mg taken twice daily, about 12 hours apart. The maximum recommended dose is 10 mg twice daily. It is taken orally with or without food.
Common side effects of Axitinib include high blood pressure, diarrhea, and fatigue. These effects vary among individuals and should be discussed with a doctor if they become severe or persistent.
Axitinib can increase the risk of high blood pressure and blood clots. It is not recommended for people with severe liver problems. Regular monitoring and consultation with a doctor are essential.
Indications and Purpose
How does Axitinib work?
Axitinib works by inhibiting tyrosine kinases, which are proteins that help cancer cells grow and spread. Think of it like turning off a switch that powers cancer cell growth. By blocking these proteins, Axitinib slows the progression of cancer and can shrink tumors. This makes it effective for treating advanced renal cell carcinoma, which is a type of kidney cancer.
Is Axitinib effective?
Axitinib is effective in treating advanced renal cell carcinoma, which is a type of kidney cancer. Clinical studies show that Axitinib can slow the progression of the disease and improve survival rates. It works by inhibiting proteins that promote cancer cell growth. Your doctor will monitor your response to the medication to ensure it's working effectively for your condition.
What is Axitinib?
Axitinib is a medication used to treat advanced renal cell carcinoma, which is a type of kidney cancer. It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking proteins that promote cancer cell growth. Axitinib helps slow the progression of the disease and can improve survival rates. It's usually used when other treatments haven't worked or are no longer effective.
Directions for Use
For how long do I take Axitinib?
Axitinib is usually a long-term medication for managing advanced renal cell carcinoma, which is a type of kidney cancer. You'll typically take Axitinib every day as part of your cancer treatment plan unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Axitinib treatment.
How do I dispose of Axitinib?
If you can, bring unused Axitinib to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Axitinib?
Take Axitinib exactly as your doctor prescribes. It's usually taken twice daily, about 12 hours apart, with or without food. Swallow the tablets whole with water; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Axitinib to start working?
Axitinib begins working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and how your cancer responds to the treatment. Regular monitoring by your doctor will help assess the effectiveness of Axitinib for your condition.
How should I store Axitinib?
Store Axitinib tablets at room temperature, away from moisture and light. Keep them in their original container with the lid tightly closed. Don't store your medicine in humid places like bathrooms, where moisture in the air could affect how well the medication works. Always store Axitinib out of children's reach to prevent accidental swallowing.
What is the usual dose of Axitinib?
The usual starting dose of Axitinib for adults is 5 mg taken twice daily, about 12 hours apart. Your doctor may adjust your dose based on how you respond to the treatment and any side effects you experience. The maximum recommended dose is 10 mg twice daily. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Axitinib be taken safely while breastfeeding?
Axitinib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. However, due to potential risks to the nursing infant, it's best to avoid using Axitinib while breastfeeding. If you're taking Axitinib and want to breastfeed, talk with your doctor about safer medication options.
Can Axitinib be taken safely while pregnant?
Axitinib is not recommended during pregnancy due to potential risks to the unborn baby. There is limited information on its safety in pregnant women, but animal studies suggest it could harm fetal development. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Can I take Axitinib with other prescription drugs?
Axitinib can interact with certain medications, increasing the risk of side effects or reducing its effectiveness. For example, strong CYP3A4 inhibitors like ketoconazole can increase Axitinib levels, while inducers like rifampin can decrease its effectiveness. Always inform your doctor about all the medicines you take to manage potential interactions and ensure safe treatment.
Does Axitinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Axitinib include high blood pressure, diarrhea, and fatigue. Serious side effects can include blood clots and liver problems. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring and communication with your healthcare provider can help manage these effects.
Does Axitinib have any safety warnings?
Yes, Axitinib has important safety warnings. It can increase the risk of high blood pressure and blood clots. Monitor your blood pressure regularly. If you experience symptoms like chest pain, shortness of breath, or swelling, seek medical help immediately. Axitinib can also cause liver problems, so regular liver function tests are recommended. Always follow your doctor's advice and report any unusual symptoms.
Is Axitinib addictive?
Axitinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Axitinib works by inhibiting certain proteins involved in cancer cell growth, and this mechanism doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Axitinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Axitinib, such as high blood pressure and fatigue. Regular monitoring by a healthcare provider is important to manage these risks. Axitinib can be used safely in the elderly with careful dose adjustments and monitoring. Always consult your doctor about any concerns specific to elderly patients.
Is it safe to drink alcohol while taking Axitinib?
It's best to avoid alcohol while taking Axitinib. Alcohol can increase the risk of liver problems and worsen side effects like dizziness or high blood pressure. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Axitinib for personalized advice.
Is it safe to exercise while taking Axitinib?
You can exercise while taking Axitinib, but keep a few things in mind. This medication can cause high blood pressure and fatigue, which might affect your exercise capacity. To exercise safely, monitor your blood pressure and listen to your body. If you feel dizzy or unusually tired, slow down or stop exercising and rest. Check with your doctor if you have concerns about your specific situation.
Is it safe to stop Axitinib?
Stopping Axitinib suddenly can affect your cancer treatment. It's important to follow your doctor's advice on how to stop or adjust your medication. Your doctor might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Always talk with your doctor before stopping Axitinib to ensure any changes are made safely.
What are the most common side effects of Axitinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Axitinib include diarrhea, high blood pressure, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Axitinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Axitinib?
Don't take Axitinib if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Axitinib is not recommended for people with severe liver problems, as it can worsen liver function. Use caution if you have high blood pressure or a history of blood clots. Always consult your doctor about these concerns before starting Axitinib.
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