Avatrombopag
Thrombocytopenia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
NA
Controlled Drug Substance
NO
Avatrombopag
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Click HereSummary
Avatrombopag is used to treat low platelet counts in adults with chronic liver disease who are scheduled for a procedure, and in those with chronic immune thrombocytopenia who have not responded to other treatments.
Avatrombopag works by stimulating the production of platelets, which are essential for blood clotting. It does this by activating the thrombopoietin receptor, which leads to increased platelet production.
For adults with chronic liver disease, the usual dose is 40 mg to 60 mg once daily for 5 days. For chronic immune thrombocytopenia, the starting dose is 20 mg once daily, adjusted based on platelet response.
Common side effects of Avatrombopag include headache, fatigue, and nausea. Serious adverse effects include thrombotic events, which occur in some patients.
Avatrombopag can increase the risk of blood clots, especially in patients with chronic liver disease or chronic immune thrombocytopenia. It should not be used to normalize platelet counts. Pregnant and breastfeeding women should avoid using it.
Indications and Purpose
What is Avatrombopag used for?
Avatrombopag is indicated for treating thrombocytopenia in adults with chronic liver disease scheduled for a procedure and in those with chronic immune thrombocytopenia who have not responded to other treatments. It helps increase platelet counts to reduce the risk of bleeding.
How does Avatrombopag work?
Avatrombopag is a thrombopoietin receptor agonist that stimulates the proliferation and differentiation of megakaryocytes, the cells responsible for producing platelets. This leads to an increase in platelet production, helping to prevent bleeding in patients with low platelet counts.
Is Avatrombopag effective?
Avatrombopag has been shown to effectively increase platelet counts in patients with chronic liver disease and chronic immune thrombocytopenia. Clinical trials demonstrated that it reduces the need for platelet transfusions and helps maintain platelet counts above 50×10^9/L, reducing bleeding risk during procedures.
How does one know if Avatrombopag is working?
The benefit of Avatrombopag is evaluated by monitoring platelet counts before, during, and after treatment. For chronic liver disease, counts are checked before and on the day of the procedure. For chronic immune thrombocytopenia, counts are monitored weekly until stable, then monthly, and weekly for 4 weeks after stopping treatment.
Directions for Use
What is the usual dose of Avatrombopag?
For adults with chronic liver disease scheduled for a procedure, the usual dose is 40 mg to 60 mg once daily for 5 days, depending on platelet count. For chronic immune thrombocytopenia, the starting dose is 20 mg once daily, adjusted based on platelet response. Safety and effectiveness in children have not been established.
How do I take Avatrombopag?
Avatrombopag should be taken with food to enhance absorption. There are no specific food restrictions, but it is important to follow the prescribed dosing schedule and not to take more or less than directed by your healthcare provider.
For how long do I take Avatrombopag?
For chronic liver disease patients undergoing a procedure, Avatrombopag is typically used for 5 days. For chronic immune thrombocytopenia, it is used as long as directed by a healthcare provider, with regular monitoring of platelet counts.
How long does it take for Avatrombopag to start working?
Avatrombopag typically starts to increase platelet counts within 3 to 5 days of starting treatment, with peak effects observed after 10 to 13 days. Patients should follow their healthcare provider's instructions and attend all scheduled appointments for monitoring.
How should I store Avatrombopag?
Store Avatrombopag at room temperature between 68°F to 77°F (20°C to 25°C). Keep it in its original package, away from excess heat and moisture, and out of reach of children. Do not store it in the bathroom.
Warnings and Precautions
Who should avoid taking Avatrombopag?
Avatrombopag can increase the risk of blood clots, especially in patients with chronic liver disease or chronic immune thrombocytopenia. It should not be used to normalize platelet counts. Patients with known risk factors for thromboembolism should be monitored closely. Pregnant and breastfeeding women should avoid using it.
Can I take Avatrombopag with other prescription drugs?
Avatrombopag's effectiveness can be affected by drugs that inhibit or induce CYP2C9 and CYP3A4 enzymes. Strong inhibitors like fluconazole can increase its levels, while inducers like rifampin can decrease its effectiveness. Dose adjustments may be necessary when taken with these medications.
Can I take Avatrombopag with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Avatrombopag be taken safely while pregnant?
Avatrombopag may cause fetal harm based on animal studies, but there is insufficient data from human studies. Pregnant women should be advised of potential risks, and the drug should only be used if the benefits justify the potential risks to the fetus.
Can Avatrombopag be taken safely while breastfeeding?
Breastfeeding is not recommended during treatment with Avatrombopag and for at least 2 weeks after the last dose due to the potential for serious adverse reactions in a breastfed child. Women should discuss alternative feeding options with their healthcare provider.
Is Avatrombopag safe for the elderly?
Clinical studies did not include enough subjects aged 65 and over to determine if they respond differently from younger patients. However, no differences in responses between elderly and younger patients have been identified. Elderly patients should use Avatrombopag under close medical supervision.
Is it safe to exercise while taking Avatrombopag?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Is it safe to drink alcohol while taking Avatrombopag?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.